Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kei Ishizuka"'
Autor:
Hyun Young Kim, Sadatsugu Sakane, Alvaro Eguileor, Raquel Carvalho Gontijo Weber, Wonseok Lee, Xiao Liu, Kevin Lam, Kei Ishizuka, Sara Brin Rosenthal, Karin Diggle, David A. Brenner, Tatiana Kisseleva
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 93-106 (2024)
Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is c
Externí odkaz:
https://doaj.org/article/0f9a90d94d5e4bd0a2e4ea88044b0319
Autor:
Hironao Okubo, Hitoshi Ando, Kei Ishizuka, Jun-ichi Morishige, Kenichi Ikejima, Shuichiro Shiina, Akihito Nagahara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 6-13 (2022)
This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HC
Externí odkaz:
https://doaj.org/article/ca4e65d644cd465c9895d47437e6d33c
Autor:
Takahiro Nishio, Yukinori Koyama, Hiroaki Fuji, Kei Ishizuka, Keiko Iwaisako, Kojiro Taura, Etsuro Hatano, David A. Brenner, Tatiana Kisseleva
Publikováno v:
Biology, Vol 11, Iss 11, p 1589 (2022)
Fibrosis is a common consequence of abnormal wound healing, which is characterized by infiltration of myofibroblasts and formation of fibrous scar. In liver fibrosis, activated Hepatic Stellate Cells (aHSCs) and activated Portal Fibroblasts (aPFs) ar
Externí odkaz:
https://doaj.org/article/34b4b401b4e04b70aec2d303d8b03733
Autor:
Hironao Okubo, Hitoshi Ando, Kei Ishizuka, Ryuta Kitagawa, Shoki Okubo, Hiroaki Saito, Shigehiro Kokubu, Akihisa Miyazaki, Kenichi Ikejima, Shuichiro Shiina, Akihito Nagahara
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229772 (2020)
BACKGROUND:Fatigue is a common adverse event during lenvatinib treatment in patients with hepatocellular carcinoma. One mechanism contributing to development of fatigue might involve abnormal adenosine triphosphate synthesis that is caused by carniti
Externí odkaz:
https://doaj.org/article/6265dca225ab45c8982a1ca22733884f
Autor:
Ganguly, Souradipta, Rosenthal, Sara Brin, Kei Ishizuka, Troutman, Ty D., Rohm, Theresa V., Khader, Naser, Aleman-Muench, German, Yasuyo Sano, Archilei, Sebastiano, Soroosh, Pejman, Olefsky, Jerrold M., Feldstein, Ariel E., Kisseleva, Tatiana, Loomba, Rohit, Glass, Christopher K., Brenner, David A., Dhar, Debanjan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 8/27/2024, Vol. 121 Issue 35, p1-30, 39p
Autor:
Kazuyoshi Kon, Shunhei Yamashina, Shuichiro Shiina, Kenichi Ikejima, Kei Ishizuka, Shoki Okubo, Kentaro Ito, Wataru Yamagata, Akihito Nagahara, Hironao Okubo, Hiroaki Saito
Publikováno v:
Kanzo. 61:715-721
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b76726d4c32d582dce2d85d60a26a17
https://doi.org/10.2957/kanzo.61.715
https://doi.org/10.2957/kanzo.61.715
Autor:
Kazuyoshi Kon, Kenichi Ikejima, Takehiko Yokomizo, Hyeon-Cheol Lee-Okada, Shunhei Yamashina, Kei Ishizuka, Kumiko Arai, Akira Uchiyama
Publikováno v:
Journal of Gastroenterology and Hepatology. 35:1437-1448
Background and aim Aging is an independent risk factor for the progression of non-alcoholic steatohepatitis. Here, we investigated the role of age-related alterations in fatty acid metabolism in dietary steatohepatitis using lipidomics analysis. Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65eeecda6c66eff3449067f2a28a78a4
https://doi.org/10.1111/jgh.15006
https://doi.org/10.1111/jgh.15006
Autor:
Akihito Nagahara, Shuichiro Shiina, Hironao Okubo, Kenichi Ikejima, Hitoshi Ando, Jun-ichi Morishige, Kei Ishizuka
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 6-13 (2022)
This prospective study examined the impact of genetic polymorphisms on the pharmacokinetics and clinical efficacy and safety of lenvatinib, a substrate of ATP-binding transporters, in a cohort of 48 Japanese patients with hepatocellular carcinoma (HC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5bdacbb53d4d040492fd6353ce4041b
https://pubmed.ncbi.nlm.nih.gov/34924131
https://pubmed.ncbi.nlm.nih.gov/34924131
Autor:
Kazuyoshi Kon, Kei Ishizuka, Hyeon-Cheol Lee, Kumiko Arai, Akira Uchiyama, Hiroo Fukada, Shunhei Yamashina, Takehiko Yokomizo, Kenichi Ikejima
Publikováno v:
Journal of Hepatology. 73:S667-S668
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833c91b46155698984d2511e8a1e5bab
https://doi.org/10.1016/s0168-8278(20)31796-7
https://doi.org/10.1016/s0168-8278(20)31796-7
Autor:
Kei Ishizuka, Shoki Okubo, Akihisa Miyazaki, Akihito Nagahara, Kenichi Ikejima, Hitoshi Ando, Shigehiro Kokubu, Hironao Okubo, Ryuta Kitagawa, Shuichiro Shiina, Hiroaki Saito
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0229772 (2020)
PLoS ONE, Vol 15, Iss 3, p e0229772 (2020)
Background Fatigue is a common adverse event during lenvatinib treatment in patients with hepatocellular carcinoma. One mechanism contributing to development of fatigue might involve abnormal adenosine triphosphate synthesis that is caused by carniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c639294b0232e8d0cb240ce8c9e26e
https://doi.org/10.1371/journal.pone.0229772
https://doi.org/10.1371/journal.pone.0229772