Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kei Ichi Takata"'
Autor:
Geunil Yi, Yubin Sung, Chanwoo Kim, Jae Sun Ra, Hirokazu Hirakawa, Takamitsu A Kato, Akira Fujimori, Hajin Kim, Kei-ichi Takata
Publikováno v:
Nucleic Acids Research. 51:2257-2269
DNA polymerase θ (POLQ) is a unique DNA polymerase that is able to perform microhomology-mediated end-joining as well as translesion synthesis (TLS) across an abasic (AP) site and thymine glycol (Tg). However, the biological significance of the TLS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd961f6c8e239a7626f0c702b3c3ab5d
https://doi.org/10.1093/nar/gkad076
https://doi.org/10.1093/nar/gkad076
Autor:
Jung-Min Oh, Yujin Kang, Jumi Park, Yubin Sung, Dayoung Kim, Yuri Seo, Eun A Lee, Jae Sun Ra, Enkhzul Amarsanaa, Young-Un Park, Seon Young Lee, Jung Me Hwang, Hongtae Kim, Orlando Schärer, Seung Woo Cho, Changwook Lee, Kei-ichi Takata, Ja Yil Lee, Kyungjae Myung
Publikováno v:
Nucleic Acids Research.
DNA double-strand break (DSB) repair via homologous recombination is initiated by end resection. The extent of DNA end resection determines the choice of the DSB repair pathway. Nucleases for end resection have been extensively studied. However, it i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4872204eb805556eb09dc000ad1582
https://doi.org/10.1093/nar/gkad308
https://doi.org/10.1093/nar/gkad308
Autor:
William Plunkett, Walter N. Hittelman, Richard D. Wood, Chaomei Liu, Billie Nowak, Kei-ichi Takata, Yingjun Jiang, Xiaojun Liu
Supplemental Figure S6 shows time-lapse video microscopy of lung cancer H460 cells after washout of CNDAC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033cf1546c631fee20bb58010474b735
https://doi.org/10.1158/1535-7163.22506760
https://doi.org/10.1158/1535-7163.22506760
Autor:
William Plunkett, Walter N. Hittelman, Richard D. Wood, Chaomei Liu, Billie Nowak, Kei-ichi Takata, Yingjun Jiang, Xiaojun Liu
Supplemental Table S1 shows increase in multinucleate cells after washout of CNDAC - a 15-hr schedule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4727b778c273264f7385cc00528e1e65
https://doi.org/10.1158/1535-7163.22506751
https://doi.org/10.1158/1535-7163.22506751
Autor:
William Plunkett, Walter N. Hittelman, Richard D. Wood, Chaomei Liu, Billie Nowak, Kei-ichi Takata, Yingjun Jiang, Xiaojun Liu
Incorporation of the clinically active deoxycytidine analogue 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single-strand breaks that are subsequently converted to double-strand breaks (DSB). Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d3a84ba2940ffaad5e1d78b8c533f5
https://doi.org/10.1158/1535-7163.c.6538486.v1
https://doi.org/10.1158/1535-7163.c.6538486.v1
Autor:
Kei-Ichi Takata, Shelley Reh, Matthew J Yousefzadeh, Maciej J Zelazowski, Sarita Bhetawal, David Trono, Megan G Lowery, Maria Sandoval, Yoko Takata, Yue Lu, Kevin Lin, Jianjun Shen, Donna F Kusewitt, Kevin M McBride, Francesca Cole, Richard D Wood
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006818 (2017)
DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth analysis of pol ν-defective mice and human cells. POLN is very weakly expressed in most tis
Externí odkaz:
https://doaj.org/article/6d5d463c02ec4d53ab818f5ddb19643b
Autor:
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)
Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Ou
Externí odkaz:
https://doaj.org/article/4231e2dcb1ae482db01a1c9297868d19
Autor:
Hajin Kim, Park Y, Lee Ea, Orlando D. Schärer, Kang Y, Amarsanaa E, Cho Sw, Ja Yil Lee, Oh J, Ra Js, Kei Ichi Takata, Jung-Wook Park, Kyungjae Myung, Dong-Joo Kim, Sung Y, Lee C, Seo Y
SUMMARYDNA double strand break (DSB) repair by Homologous recombination (HR) is initiated by the end resection, a process during which 3’ ssDNA overhangs are generated by the nucleolytic degradation. The extent of DNA end resection determines the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e49d2ddef66b2e725b299d98c0cff434
https://doi.org/10.1101/2021.04.23.441074
https://doi.org/10.1101/2021.04.23.441074
Autor:
Shelley Reh, Jong Bhak, Yoko Takata, John P. Murnane, Yi Zhong, Semin Lee, Taejoo Hwang, Yerkin Dunbayev, Jianjun Shen, Kei Ichi Takata, Richard D. Wood, Kevin M. McBride
Publikováno v:
Nar Cancer
DNA polymerase theta (POLQ)-mediated end joining (TMEJ) is a distinct pathway for mediating DNA double-strand break (DSB) repair. TMEJ is required for the viability of BRCA-mutated cancer cells. It is crucial to identify tumors that rely on POLQ acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e5dfa4113f7ae70a1562fc52a06222
https://doi.org/10.1093/narcan/zcaa017
https://doi.org/10.1093/narcan/zcaa017
Autor:
Kei Ichi Takata, Walter N. Hittelman, Chaomei Liu, William Plunkett, Billie Nowak, Richard D. Wood, Xiaojun Liu, Yingjun Jiang
Publikováno v:
Mol Cancer Ther
Incorporation of the clinically active deoxycytidine analogue 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single-strand breaks that are subsequently converted to double-strand breaks (DSB). Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef424be87db14bb9ee096c0abcc6f1fd
https://europepmc.org/articles/PMC7433019/
https://europepmc.org/articles/PMC7433019/