Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kei Fukuda"'
Autor:
Jumpei Taguchi, Hirofumi Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, Akito Tanaka, Sho Ohta, Tomoyo Ukai, Kanae Mitsunaga, Yosuke Yamada, So I Nagaoka, Sho Yamazawa, Kotaro Ohnishi, Knut Woltjen, Tetsuo Ushiku, Manabu Ozawa, Mitinori Saitou, Yoichi Shinkai, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and d
Externí odkaz:
https://doaj.org/article/ce67fa07507345ab98bca02b31126aed
Autor:
Kei Fukuda, Chikako Shimura, Hisashi Miura, Akie Tanigawa, Takehiro Suzuki, Naoshi Dohmae, Ichiro Hiratani, Yoichi Shinkai
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Kei Fukuda et al. show that the formation of chromatin domains marked by dimethylated H3K9 is functionally linked to the 3D organization of the genome. These findings suggest that H3K9 methyltransferases play an important role in maintaining genome o
Externí odkaz:
https://doaj.org/article/e89beff64c854c29ab9276b1ff88ac50
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background The histone methyltransferase SETDB1 (also known as ESET) represses genes and various types of transposable elements, such as endogenous retroviruses (ERVs) and integrated exogenous retroviruses, through a deposition of trimethyla
Externí odkaz:
https://doaj.org/article/1a336a02ce5947b6bb5df52d9aa282a2
Autor:
Kei Fukuda, Yoshinori Makino, Satoru Kaneko, Chikako Shimura, Yuki Okada, Kenji Ichiyanagi, Yoichi Shinkai
Publikováno v:
eLife, Vol 11 (2022)
DNA methylation, repressive histone modifications, and PIWI-interacting RNAs are essential for controlling retroelement silencing in mammalian germ lines. Dysregulation of retroelement silencing is associated with male sterility. Although retroelemen
Externí odkaz:
https://doaj.org/article/ede302e6533b4adfa10cd77f596ff144
Autor:
Ayumi Yamada, Takae Hirasawa, Kayako Nishimura, Chikako Shimura, Naomi Kogo, Kei Fukuda, Madoka Kato, Masaki Yokomori, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Yoichiro Iwakura, Itoshi Nikaido, Shigeyoshi Itohara, Yoichi Shinkai
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103253- (2021)
Externí odkaz:
https://doaj.org/article/f04150f916ea4a73a1d81efd7c3cf305
Autor:
Shigeru Matsuda, Takehiro Yasukawa, Yuriko Sakaguchi, Kenji Ichiyanagi, Motoko Unoki, Kazuhito Gotoh, Kei Fukuda, Hiroyuki Sasaki, Tsutomu Suzuki, Dongchon Kang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains controversial. Herein, we exhaustively analysed mouse mtDNA using three method
Externí odkaz:
https://doaj.org/article/292dcfe424644832b38fb2830dc1be9a
Publikováno v:
Mobile DNA, Vol 8, Iss 1, Pp 1-12 (2017)
Abstract Background Intracisternal A particle (IAP) is one of the most transpositionally active retrotransposons in the mouse genome, but its expression varies between cell types. This variation is believed to arise from differences in the epigenetic
Externí odkaz:
https://doaj.org/article/eb7e24125b73468f86f359d2d286f2d3
Autor:
Kei Fukuda, Yoichi Shinkai
Publikováno v:
Viruses, Vol 12, Iss 6, p 596 (2020)
SETDB1 (SET domain bifurcated histone lysine methyltransferase 1) is a protein lysine methyltransferase and methylates histone H3 at lysine 9 (H3K9). Among other H3K9 methyltransferases, SETDB1 and SETDB1-mediated H3K9 trimethylation (H3K9me3) play p
Externí odkaz:
https://doaj.org/article/e2218e13ddef4b6ea4b94616d49f7637
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006926 (2017)
Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity. The piRNA syst
Externí odkaz:
https://doaj.org/article/1d611aeab1194adaae27fff6cdcf6d1d
Autor:
Kei Fukuda
Publikováno v:
Genes & Genetic Systems; Dec2023, Vol. 98 Issue 6, p289-304, 16p