Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kei, Takedomi"'
Autor:
Daisuke Iijima, Hiroshi Sugama, Yoichi Takahashi, Miki Hirai, Yuko Togashi, Jianshu Xie, Jingkang Shen, Ying Ke, Hidenori Akatsuka, Takayuki Kawaguchi, Kei Takedomi, Akiko Kashima, Masashi Nishio, Yosuke Inui, Hikaru Yoneda, Guangxin Xia, Toru Iijima
Publikováno v:
Journal of Medicinal Chemistry. 65:10882-10897
Renin is the rate-limiting enzyme in the renin-angiotensin-aldosterone system (RAAS) which regulates blood pressure and renal function and hence is an attractive target for the treatment of hypertension and cardiovascular/renal diseases. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7d118a6f7d7ab8858123b81a9c5444
https://doi.org/10.1021/acs.jmedchem.2c00834
https://doi.org/10.1021/acs.jmedchem.2c00834
Autor:
Toru Iijima, Makoto Katoh, Kei Takedomi, Yasuo Yamamoto, Hidenori Akatsuka, Naritoshi Shirata, Akito Nishi, Misae Takakuwa, Yoshinori Watanabe, Hitomi Munakata, Naomi Koyama, Tomoko Ikeda, Taku Iguchi, Harutoshi Kato, Kohei Kikkawa, Takayuki Kawaguchi
Publikováno v:
Journal of Medicinal Chemistry. 65:8127-8143
Overactivation of the mineralocorticoid receptor (MR) is involved in many diseases, such as hypertension, kidney disease, and heart failure. Thus, MR antagonists (MRAs) are expected to be beneficial to patients with these diseases. In order to identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2388141a3f3a9176678419018354997
https://doi.org/10.1021/acs.jmedchem.2c00402
https://doi.org/10.1021/acs.jmedchem.2c00402
Publikováno v:
Journal of Chemical Information and Modeling. 61:3583-3592
The mineralocorticoid receptor (MR) is a nuclear receptor whose endogenous ligands are mineralocorticoids, a type of steroid hormone. The activating S810L mutation is known to cause severe early-onset and pregnancy-related hypertension. Progesterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b498fc8d0eac6b1e84021439aea29e6
https://doi.org/10.1021/acs.jcim.1c00389
https://doi.org/10.1021/acs.jcim.1c00389
Autor:
Daisuke Iijima, Hiroshi Sugama, Nobumasa Awai, Yoichi Takahashi, Yuko Togashi, Tohru Takebe, Jianshu Xie, Jingkang Shen, Ying Ke, Hidenori Akatsuka, Takayuki Kawaguchi, Kei Takedomi, Akiko Kashima, Masashi Nishio, Yosuke Inui, Hikaru Yoneda, Guangxin Xia, Toru Iijima
Publikováno v:
ACS medicinal chemistry letters. 13(8)
The renin-angiotensin-aldosterone system (RAAS) plays a key role in the regulation of blood pressure. Renin, the first and rate-limiting enzyme of the RAAS, is an attractive target for the treatment of hypertension and cardiovascular/renal diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a81141cb66d003b8b8e48a18c4a8af4
https://pubmed.ncbi.nlm.nih.gov/35978678
https://pubmed.ncbi.nlm.nih.gov/35978678
Autor:
Kei Takedomi, Eiji Kawanishi, Yumi Watanabe, Mayumi Kimura, Koki Kojima, Yoichi Kadoh, Yoshihito Tanaka, Takehiko Matsumura, Kenji Omori, Tamaki Kobayashi, Toshiaki Sakamoto, Haruko Miyoshi, Jun Kotera, Toshiyuki Himiyama, Mitsuya Hongu, Takashi Sasaki, Hiroyuki Taniguchi
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:243-250
Phosphodiesterase (PDE) 10A is a dual hydrolase of cAMP and cGMP and highly expressed in striatal medium spiny neurons. Inhibition of PDE10A modulates the activity of medium spiny neurons (MSN) via the regulation of cAMP and cGMP. Signal control of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6843e881235274aefe3a3c26a35ba5a
https://doi.org/10.1248/cpb.c17-00783
https://doi.org/10.1248/cpb.c17-00783
Autor:
Takehiko Matsumura, Hiroyuki Taniguchi, Takashi Sasaki, Misae Takakuwa, Haruko Miyoshi, Yoichi Kadoh, Eiji Kawanishi, Mitsuya Hongu, Yoshihito Tanaka, Yumi Watanabe, Kei Takedomi, Nobuyuki Baba, Yuuki Koizumi, Jun Kotera, Koki Kojima, Itsuko Nakamura
Publikováno v:
Bioorganicmedicinal chemistry. 27(15)
We have developed a new class of PDE10A inhibitor, a pyrazolo[1,5-a]pyrimidine derivative MT-3014 (1). A previous compound introduced was deprioritized due to concerns for E/Z-isomerization and glutathione-adduct formation at the core stilbene struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd08f7ec18e9eee0e29fcebbf425ca7
https://pubmed.ncbi.nlm.nih.gov/31235264
https://pubmed.ncbi.nlm.nih.gov/31235264
Autor:
Yoichi, Kadoh, Haruko, Miyoshi, Takehiko, Matsumura, Yoshihito, Tanaka, Mitsuya, Hongu, Mayumi, Kimura, Kei, Takedomi, Kenji, Omori, Jun, Kotera, Takashi, Sasaki, Tamaki, Kobayashi, Hiroyuki, Taniguchi, Yumi, Watanabe, Koki, Kojima, Toshiaki, Sakamoto, Toshiyuki, Himiyama, Eiji, Kawanishi
Publikováno v:
Chemicalpharmaceutical bulletin. 66(3)
Phosphodiesterase (PDE) 10A is a dual hydrolase of cAMP and cGMP and highly expressed in striatal medium spiny neurons. Inhibition of PDE10A modulates the activity of medium spiny neurons (MSN) via the regulation of cAMP and cGMP. Signal control of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccbcba61a1f229d7503f09e9a5d3ec06
https://pubmed.ncbi.nlm.nih.gov/29491258
https://pubmed.ncbi.nlm.nih.gov/29491258
Publikováno v:
Biophysical Chemistry. :119-126
Accurate methods to predict the binding affinities of compounds for target molecules are powerful tools in structure-based drug design (SBDD). A recently developed method called massively parallel computation of absolute binding free energy with a we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddbdc675edff174359b8d1375e5f91a
https://doi.org/10.1016/j.bpc.2013.07.005
https://doi.org/10.1016/j.bpc.2013.07.005
Autor:
Tsuyoshi Ogiku, James Zapf, Shao-Hui Zhang, Kui Xu, Kei Takedomi, Naoki Sakurai, Guang Yang, Rick Jack, Jie-Fei Cheng, Miguel Barbosa, Chiaki Fukushima
Publikováno v:
Journal of Medicinal Chemistry. 51:2057-2061
We conducted virtual docking studies using GLIDE with modified LXRbeta ligand-binding domain (LBD) on internal compound collection followed by the gene profiling with ArrayPlate mRNA assay. A total of 69 compounds were found to upregulate LXRalpha an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c423f07eaac7c8768ae34ef8ec2901
https://doi.org/10.1021/jm7011326
https://doi.org/10.1021/jm7011326
Autor:
Ila Sircar, Chiaki Fukushima, Lisa Schneider, James Zapf, Madhavi Pannala, Lisa Morera, Trang Nguyen, Jie-Fei Cheng, Rick Jack, Norma Wilson, Shao-Hui Zhang, Kui Xu, Farid Bakir, Juping Liu, Kei Takedomi, Naoki Sakurai, Sunil Kher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3473-3479
A structurally novel liver X receptor (LXR) agonist (1) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. Compound 1 increased ABCA1 gene expression by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb508e31f7c0f8a1fb69a6abab291c
https://doi.org/10.1016/j.bmcl.2007.03.076
https://doi.org/10.1016/j.bmcl.2007.03.076