Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Kehui Yang"'
Autor:
Li Yang, Qiaoqiao Liu, Yaxuan Zhao, Ninghua Lin, Yue Huang, Qihui Wang, Kehui Yang, Runa Wei, Xiaotong Li, Ming Zhang, Lingyun Hao, Hongjun Wang, Zhiqiang Pan
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109016- (2024)
Summary: Experimental studies have shown that neuropathic pain impairs hippocampal synaptic plasticity. Here, we sought to determine the underlying mechanisms responsible for synaptic changes in neuropathic painful mouse hippocampal neurons. Beyond d
Externí odkaz:
https://doaj.org/article/5d1396c413a0433e887ee8bd40ebed8a
Autor:
Kehui Yang, Sumei Cui, Jingwen Wang, Tonghui Xu, Han Du, Hongwei Yue, Huaqing Ye, Jialin Guo, Jian Zhang, Pengpai Li, Yunyun Guo, Chang Pan, Jiaojiao Pang, Jiali Wang, Xiao Yu, Cheng Zhang, Zhiping Liu, Yuguo Chen, Feng Xu
Publikováno v:
Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)
Abstract The involvement of endothelial barrier function in abdominal aortic aneurysm (AAA) and its upstream regulators remains unknown. Single‐cell RNA sequencing shows that disrupted endothelial focal junction is an early (3 days) and persistent
Externí odkaz:
https://doaj.org/article/417035d27fbd4422b41b5b3b5106d395
Autor:
Qindong Guo, Yang Fan, Qingtong Wang, Boyan Li, Wei Qiu, Yanhua Qi, Ziwen Pan, Shouji Zhang, Shulin Zhao, Kehui Yang, Hao Xu, Ming Li, Zijie Gao, Jianye Xu, Huizhi Wang, Shaobo Wang, Qilin Tang, Jiawei Qiu, Xing Guo, Lin Deng, Ping Zhang, Rongrong Zhao, Hao Xue, Chengwei Wang, Gang Li
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-14 (2023)
Abstract Glioma is the most common malignant tumor of the central nervous system in adults. The tumor microenvironment (TME) is related to poor prognosis in glioma patients. Glioma cells could sort miRNA into exosomes to modify TME. And hypoxia playe
Externí odkaz:
https://doaj.org/article/e2502b3c7e944cf49f40d0b58109cd32
Autor:
Xiangkai Zhao, Jian Zhang, Jialin Guo, Jinxin Wang, Yuhui Pan, Xue Zhao, Wentao Sang, Kehui Yang, Fengyang Xu, Feng Xu, Yuguo Chen
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Dual antiplatelet therapy combining aspirin with a P2Y12 adenosine diphosphate receptor inhibitor is a therapeutic mainstay for acute coronary syndrome (ACS). However, the optimal choice of P2Y12 adenosine diphosphate receptor inhibitor i
Externí odkaz:
https://doaj.org/article/fce20aef678f460e8f08c68b164ac368
Autor:
Tonghui Xu, Jialin Guo, Maozeng Wei, Jiali Wang, Kehui Yang, Chang Pan, Jiaojiao Pang, Li Xue, Qiuhuan Yuan, Mengyang Xue, Jian Zhang, Wentao Sang, Tangxing Jiang, Yuguo Chen, Feng Xu
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of acetaldehyde and endogenous lipid aldehydes. Approximately 40% of East Asians, accounting for 8% of the human population, carry the E504K mutation in ALDH2 that
Externí odkaz:
https://doaj.org/article/e50af833991b49e5bff8f4d24dcbc02f
Autor:
Rui Zhang, Baoshan Liu, Xinhui Fan, Wenjun Wang, Tonghui Xu, Shujian Wei, Wen Zheng, Qiuhuan Yuan, Luyao Gao, Xinxin Yin, Boyuan Zheng, Chuanxin Zhang, Shuai Zhang, Kehui Yang, Mengyang Xue, Shuo Wang, Feng Xu, Jiali Wang, Yihai Cao, Yuguo Chen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Post-cardiac arrest myocardial dysfunction significantly contributes to early mortality after the return of spontaneous circulation. However, no effective therapy is available now. Aldehyde dehydrogenase 2 (ALDH2) enzyme has been shown to protect the
Externí odkaz:
https://doaj.org/article/0151af5fdac34832a6b5f7432fc3f97a
Autor:
Hui-Min Zhou, Heng-Jun Xu, Run-Hang Sun, Ming Zhang, Xiao-Tong Li, Ya-Xuan Zhao, Kehui Yang, Runa Wei, Qiaoqiao Liu, Siyuan Li, Zhouya Xue, Ling-Yun Hao, Li Yang, Qi-Hui Wang, Hong-Jun Wang, Fang Gao, Jun-Li Cao, Zhiqiang Pan
Publikováno v:
PAIN; Jan2024, Vol. 165 Issue 1, p75-91, 17p
Autor:
Ming Zhang, Kehui Yang, Qi-Hui Wang, Ling Xie, Qiaoqiao Liu, Runa Wei, Yang Tao, Hong-Li Zheng, Ninghua Lin, Hengjun Xu, Li Yang, Hongjun Wang, Tingruo Zhang, Zhouya Xue, Jun-Li Cao, Zhiqiang Pan
Publikováno v:
The Journal of Neuroscience. 43:3009-3027
RNA N4-acetylcytidine (ac4C) modification is increasingly recognized as an important layer of gene regulation; however, the involvement of ac4C in pain regulation has not been studied. Here, we report that N-acetyltransferase 10 protein (NAT10; the o
Autor:
Jian Zhang, Xiangkai Zhao, Yunyun Guo, Zhiping Liu, Shujian Wei, Qiuhuan Yuan, Haixia Shang, Wentao Sang, Sumei Cui, Tonghui Xu, Kehui Yang, Jialin Guo, Chang Pan, Jiali Wang, Jiaojiao Pang, Tianrui Han, Yuguo Chen, Feng Xu
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:700-716
Background: Clinical studies show that the most common single-point mutation in humans, ALDH2 (aldehyde dehydrogenase 2) rs671 mutation, is a risk factor for the development and poor prognosis of atherosclerotic cardiovascular diseases, but the under
Autor:
Fuqing, Lin, Hongli, Zheng, Shiyu, Sun, Tong, Jin, Ming, Zhang, Ying, Zeng, Qiaoqiao, Liu, Runa, Wei, Kehui, Yang, Zhiqiang, Pan
Publikováno v:
Molecular pain.
Nerve injury can induce aberrant changes in ion channels, enzymes, and cytokines/chemokines in the dorsal root ganglia (DRGs); these changes are due to or at least partly governed by transcription factors that contribute to the genesis of neuropathic