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Akademický článek

HSP90 is part of a protein complex with the L polymerase of Rift Valley fever phlebovirus and prevents its degradation by the proteasome during the viral genome replication/transcription stage

Autor: Farhang Alem, Ashwini Brahms, Kaori Tarasaki, Samson Omole, Kylene Kehn-Hall, Connie S. Schmaljohn, Sina Bavari, Shinji Makino, Ramin M. Hakami

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

The mosquito-borne Rift Valley fever virus (RVFV) from the Phenuiviridae family is a single-stranded RNA virus that causes the re-emerging zoonotic disease Rift Valley fever (RVF). Classified as a Category A agent by the NIH, RVFV infection can cause

Externí odkaz: https://doaj.org/article/bf372d6714b84a879e31760e2a0f982d

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Akademický článek

An LIR motif in the Rift Valley fever virus NSs protein is critical for the interaction with LC3 family members and inhibition of autophagy.

Autor: Kaylee Petraccione, Mohamed G H Ali, Normand Cyr, Haytham M Wahba, Timothy Stocker, Maryna Akhrymuk, Ivan Akhrymuk, Lauren Panny, Nicole Bracci, Raphaël Cafaro, Danuta Sastre, Andrew Silberfarb, Paul O'Maille, James Omichinski, Kylene Kehn-Hall

Publikováno v: PLoS Pathogens, Vol 20, Iss 3, p e1012093 (2024)

Rift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans. The nonstructural small (NSs) protein is the primary virulence factor of RVFV that suppresses the host's antiviral innate immune response. Bioinfor

Externí odkaz: https://doaj.org/article/080232048ca04318a75327164da80aa8

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