788 FIRST IN HUMAN TRIAL OF IMU-856, AN ORALLY AVAILABLE EPIGENETIC MODULATOR OF BARRIER REGENERATION FOR THE TREATMENT OF CELIAC DISEASE

Autor: Buriánek, Franziska, Pröbstl, Doris, Peelen, Evelyn, Fonseca, Juliano, Schreieck, Amelie, Wirth, Martina, Kehler, Inge, Vitt, Daniel, Kohlhof, Hella, Muehler, Andreas

Publikováno v: In Gastroenterology 18-21 May 2024 166(5) Supplement:S

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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Autor: Schütte M; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany., Risch T; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Abdavi-Azar N; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Boehnke K; Eli Lilly and Company, Lilly Research Laboratories, Quantitative Biology, Avda. de la Industria 30, Alcobendas, 28108 Madrid, Spain., Schumacher D; Charité-Universitätsmedizin Berlin, Institute of Pathology, Laboratory for Molecular Tumour Pathology, Charitéplatz 1, 10117 Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69192 Heidelberg, Germany., Keil M; Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO), Robert-Roessle-Str. 10, 13125 Berlin, Germany., Yildiriman R; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany., Jandrasits C; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Borodina T; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany., Amstislavskiy V; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Worth CL; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Schweiger C; Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria., Liebs S; Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany., Lange M; Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany., Warnatz HJ; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Butcher LM; UCL Cancer Institute, University College London, London WC1E 6BT, UK.; Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK., Barrett JE; UCL Cancer Institute, University College London, London WC1E 6BT, UK., Sultan M; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany., Wierling C; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany., Golob-Schwarzl N; Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.; Center for Biomarker Research in Medicine, Stiftingtalstrasse 5, 8010 Graz, Austria., Lax S; Department of Pathology, Hospital Graz Süd-West, Göstinger Straße 22, 8020 Graz, Austria., Uranitsch S; Department of Surgery, Hospital Brothers of Charity Graz, Marschallgasse 12, 8020 Graz, Austria., Becker M; Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO), Robert-Roessle-Str. 10, 13125 Berlin, Germany., Welte Y; Charité-Universitätsmedizin Berlin, Institute of Pathology, Laboratory for Molecular Tumour Pathology, Charitéplatz 1, 10117 Berlin, Germany.; CPO-Cellular Phenomics&Oncology, Berlin-Buch GmbH, Robert-Rössle-Str. 10, 13125 Berlin, Germany., Regan JL; Bayer Pharma AG, Müllerstraße 178, 13353 Berlin, Germany., Silvestrov M; Charité-Universitätsmedizin Berlin, Institute of Pathology, Laboratory for Molecular Tumour Pathology, Charitéplatz 1, 10117 Berlin, Germany.; CPO-Cellular Phenomics&Oncology, Berlin-Buch GmbH, Robert-Rössle-Str. 10, 13125 Berlin, Germany., Kehler I; Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany., Fusi A; Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany., Kessler T; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany., Herwig R; Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, Ihnestrasse 73, D-14195 Berlin, Germany., Landegren U; Department of Immunology, Genetics and Pathology, SciLifeLab, Uppsala University, Box 815, SE-751 08 Uppsala, Sweden., Wienke D; Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany., Nilsson M; Department of Immunology, Genetics and Pathology, SciLifeLab, Uppsala University, Box 815, SE-751 08 Uppsala, Sweden.; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Tomtebodavägem 23A, 17165 Solna, Stockholm, Sweden., Velasco JA; Eli Lilly and Company, Lilly Research Laboratories, Quantitative Biology, Avda. de la Industria 30, Alcobendas, 28108 Madrid, Spain., Garin-Chesa P; Boehringer Ingelheim RCV GmbH &Co KG, Dr. Boehringer-Gasse 5-11, A-1121 Wien, Austria., Reinhard C; Eli Lilly and Company, Lilly Research Laboratories, Oncology Translational Research, Lilly Corporate Center, Indianapolis, Indiana 46285, USA., Beck S; UCL Cancer Institute, University College London, London WC1E 6BT, UK., Schäfer R; Charité-Universitätsmedizin Berlin, Institute of Pathology, Laboratory for Molecular Tumour Pathology, Charitéplatz 1, 10117 Berlin, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69192 Heidelberg, Germany., Regenbrecht CR; Charité-Universitätsmedizin Berlin, Institute of Pathology, Laboratory for Molecular Tumour Pathology, Charitéplatz 1, 10117 Berlin, Germany.; CPO-Cellular Phenomics&Oncology, Berlin-Buch GmbH, Robert-Rössle-Str. 10, 13125 Berlin, Germany., Henderson D; Bayer Pharma AG, Global External Innovation &Alliances, Müllerstraße 178, 13353 Berlin, Germany., Lange B; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany., Haybaeck J; Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria.; Center for Biomarker Research in Medicine, Stiftingtalstrasse 5, 8010 Graz, Austria., Keilholz U; Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany., Hoffmann J; Experimental Pharmacology and Oncology Berlin-Buch GmbH (EPO), Robert-Roessle-Str. 10, 13125 Berlin, Germany., Lehrach H; Alacris Theranostics GmbH, Fabeckstr. 60-62, D-14195 Berlin, Germany.; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany.; Dahlem Centre for Genome Research and Medical Systems Biology, Fabeckstr. 60-62, 14195 Berlin, Germany., Yaspo ML; Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics/Otto Warburg Laboratory Gene Regulation and Systems Biology of cancer, Ihnestrasse 73, D-14195 Berlin, Germany.

Publikováno v: Nature communications [Nat Commun] 2017 Feb 10; Vol. 8, pp. 14262. Date of Electronic Publication: 2017 Feb 10.