Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Kehkooi Kee"'
Autor:
Jiana Huang, Peigen Chen, Lei Jia, Tingting Li, Xing Yang, Qiqi Liang, Yanyan Zeng, Jiawen Liu, Taibao Wu, Wenqi Hu, Kehkooi Kee, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou
Publikováno v:
Advanced Science, Vol 10, Iss 26, Pp n/a-n/a (2023)
Abstract Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal aging. Transcriptional silencing makes translational control an urgent task during meiosis resumption in maternal aging. However, insights into aging‐rel
Externí odkaz:
https://doaj.org/article/a6c1e91f7c1a4109acb799cd82cea112
Autor:
Wenqi Hu, Haitao Zeng, Yanan Shi, Chuanchuan Zhou, Jiana Huang, Lei Jia, Siqi Xu, Xiaoyu Feng, Yanyan Zeng, Tuanlin Xiong, Wenze Huang, Peng Sun, Yajie Chang, Tingting Li, Cong Fang, Keliang Wu, Lingbo Cai, Wuhua Ni, Yan Li, Zhiyong Yang, Qiangfeng Cliff Zhang, RiCheng Chian, Zijiang Chen, Xiaoyan Liang, Kehkooi Kee
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Development of methods for simultaneous single cell analysis of transcription and translation is still underway. Here, Hu et al. develop single-cell transcriptome and translatome dual-omics on human oocytes, which enables them to identify OOSP2 as an
Externí odkaz:
https://doaj.org/article/6ca410494d72486ebe97c1923beedc55
Autor:
Haipeng Fu, Tingyu Wang, Xiaohui Kong, Kun Yan, Yang Yang, Jingyi Cao, Yafei Yuan, Nan Wang, Kehkooi Kee, Zhi John Lu, Qiaoran Xi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Fu et al. identify the highly conserved, transmembrane micropeptide, NEMEP, as a direct target of Nodal signaling, essential for mesendoderm differentiation. NEMEP interacts with the glucose transporters GLUT1/GLUT3 and promotes glucose uptake.
Externí odkaz:
https://doaj.org/article/3ec7c912d0c845bc86e050e581c46bdd
Publikováno v:
eLife, Vol 12 (2023)
Non-coding RNAs exert diverse functions in many cell types. In addition to transcription factors from coding genes, non-coding RNAs may also play essential roles in shaping and directing the fate of germ cells. The presence of many long non-coding RN
Externí odkaz:
https://doaj.org/article/b45a46fff29f407b83c8a0275c9212fa
Autor:
Hongying Gao, Chunwei Zheng, Jian Du, Yue Wu, Yonghui Sun, Chunsheng Han, Kehkooi Kee, Yu Rao
Publikováno v:
Protein & Cell, Vol 11, Iss 7, Pp 534-539 (2020)
Externí odkaz:
https://doaj.org/article/f823a0d78f934416b16acd7154578111
Autor:
Bo Chen, Gengzhen Zhu, An Yan, Jing He, Yang Liu, Lin Li, Xuerui Yang, Chen Dong, Kehkooi Kee
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009778 (2021)
Meiosis initiation and progression are regulated by both germ cells and gonadal somatic cells. However, little is known about what genes or proteins connecting somatic and germ cells are required for this regulation. Our results show that deficiency
Externí odkaz:
https://doaj.org/article/d38d544322054ec993d85cad0a8e0a6f
Autor:
Wenhua Kuang, Jie Zhang, Zhou Lan, R.N.V. Krishna Deepak, Chao Liu, Zhilong Ma, Lili Cheng, Xinbin Zhao, Xianbin Meng, Weihua Wang, Xueying Wang, Lina Xu, Yupei Jiao, Qi Luo, Ziyi Meng, Kehkooi Kee, Xiaohui Liu, Haiteng Deng, Wei Li, Hao Fan, Ligong Chen
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109025- (2021)
Summary: Ablation of Slc22a14 causes male infertility in mice, but the underlying mechanisms remain unknown. Here, we show that SLC22A14 is a riboflavin transporter localized at the inner mitochondrial membrane of the spermatozoa mid-piece and show b
Externí odkaz:
https://doaj.org/article/bf6c865da545426caec55f4e1189d344
Autor:
Yun Gao, Lin Li, Peng Yuan, Fan Zhai, Yixin Ren, Liying Yan, Rong Li, Ying Lian, Xiaohui Zhu, Xinglong Wu, Kehkooi Kee, Lu Wen, Jie Qiao, Fuchou Tang
Publikováno v:
PLoS Biology, Vol 18, Iss 7, p e3000799 (2020)
Epigenetic dynamics, such as DNA methylation and chromatin accessibility, have been extensively explored in human preimplantation embryos. However, the active demethylation process during this crucial period remains largely unexplored. In this study,
Externí odkaz:
https://doaj.org/article/bbed9b1f4ddc46b680a960bbec4fe512
Autor:
Zhi-Yong Yang, Min Ye, Ya-Xin Xing, Qi-Gui Xie, Jian-Hong Zhou, Xin-Rui Qi, Kehkooi Kee, Ri-Cheng Chian
Publikováno v:
Cells, Vol 11, Iss 2, p 297 (2022)
To address which mitochondria-related nuclear differentially expressed genes (DEGs) and related pathways are altered during human oocyte maturation, single-cell analysis was performed in three oocyte states: in vivo matured (M-IVO), in vitro matured
Externí odkaz:
https://doaj.org/article/edd60ae9e9784ea4bf7c225e115fb849
Autor:
Dajung Jung, Jie Xiong, Min Ye, Xunsi Qin, Lin Li, Shunfeng Cheng, Mengyuan Luo, Jia Peng, Ji Dong, Fuchou Tang, Wei Shen, Martin M. Matzuk, Kehkooi Kee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
In vitro production of human oocytes for the treatment of female infertility is a goal in reproductive medicine. Here, the authors establish in vitroconditions to generate human ovarian follicle-like cells from human embryonic stem cells.
Externí odkaz:
https://doaj.org/article/9423d3c6d4db49438f8ef5d3863d05bb