Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Keh-Chuang Chin"'
Autor:
Wei-Xiang Sin, Joe Poh-Sheng Yeong, Thomas Jun Feng Lim, I-Hsin Su, John E. Connolly, Keh-Chuang Chin
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is
Externí odkaz:
https://doaj.org/article/31bdcfeed15542c4bceeddb68c21e737
Autor:
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae-Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF
Externí odkaz:
https://doaj.org/article/fcfe5f0cdf014198b141e4fc270fc775
Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Autor:
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8 Article number: 15865 (2017); Published: 28 June 2017; Updated: 18 August 2017 The previously published version of this Article contained a line number in the Abstract within the sentence ‘A fraction of RIP2 localizes to the
Externí odkaz:
https://doaj.org/article/ddffffb5080b4efba26d0571887e537d
Autor:
Chrissie K. Lim, Youjia Zhong, Richard Hopkins, Wei-Xiang Sin, Bijin Veonice Au, Sriram Narayanan, Chiung-Hui Huang, Colin YC Lee, Ming Liang Oon, Avisha Chowdhury, Benjamin Wong, Frances Yeap, Mariflor Villegas, Julien Pompon, Patricia PL Ng, Siok-Bian Ng, Thuan Chong T Quah, Poh-Lin Tan, Keh-Chuang Chin, John E Connolly
Publikováno v:
Blood
Blood, 2023, 141 (17), pp.2151-2155. ⟨10.1182/blood.2022018309⟩
Blood, 2023, 141 (17), pp.2151-2155. ⟨10.1182/blood.2022018309⟩
International audience; Severe mosquito bite allergy (SMBA) is a manifestation of chronic active Epstein-Barr virus (CAEBV) infection defined by necrotic ulceration of the stings. CAEBV with SMBA has a high mortality rate as most patients eventually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98821442a8855542577083ccfa84ea27
https://hal.science/hal-04123658/document
https://hal.science/hal-04123658/document
Autor:
Ah Moy Tan, Lynn Xue Wu, Keh Chuang Chin, Lena Ho, Woei Kang Liew, Christopher Z.W. Lee, Saumya Shekhar Jamuar, Yongliang Zhang, Vinay Tergaonkar, Byrappa Venkatesh, Chrissie Lim, Derrick W. Q. Lian, Enrica E.K. Tan, Kok Huar Ong, John E. Connolly, Florent Ginhoux, Mark Jean Aan Koh, Jeffery Kwok, Koh Cheng Thoon, Nivashini Kaliaperumal, Sharmy S. James, Christina Ong, Andreas Alvin Pumomo Soetedjo, Biju Thomas, Ee Shien Tan, Chang Siang Lim, Richard Hopkins, Madhushanee Weerasooriya, Adrian Kee Keong Teo, L. A. Jones, Hui Yin Lee, Eun Mong Shin, Veonice Bijin Au, Anna-Marie Fairhurst, Weimiao Yu, Bruno Reversade, Edmond Chua
Publikováno v:
Journal of clinical investigation, 130(11), 5817-5832. The American Society for Clinical Investigation
J Clin Invest
J Clin Invest
Although IKK-β has previously been shown as a negative regulator of IL-1β secretion in mice, this role has not been proven in humans. Genetic studies of NF-κB signaling in humans with inherited diseases of the immune system have not demonstrated t
Autor:
I-hsin Su, Thomas Jun Feng Lim, John E. Connolly, Keh-Chuang Chin, Wei-Xiang Sin, Joe Poh-Sheng Yeong
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
IRF-7 mediates robust production of type I IFN via MyD88 of the TLR9 pathway in plasmacytoid dendritic cells (pDCs). Previous in vitro studies using bone marrow-derived dendritic cells lacking either Irf7 or Irf3 have demonstrated that only IRF-3 is
Autor:
Sai Kiang Lim, Ronne Wee Yeh Yeo, Eugene Wei Kian Sim, Ruenn Chai Lai, Bin Zhang, Keh Chuang Chin
Publikováno v:
Cytotherapy. 20(5)
Background aims The immunomodulatory property of mesenchymal stromal cell (MSC) exosomes is well documented. On the basis of our previous report that MSC exosomes increased regulatory T-cell (Treg) production in mice with allogenic skin graft but not
Autor:
Ramnik J. Xavier, Avinash R. Shenoy, Keh-Chuang Chin, Michelle Hong, Matija Hedl, Hanif Javanmard Khameneh, Clara Abraham, Pradeep Bist, Albert Neutzner, Alessandra Mortellaro, John D. MacMicking, Vanniarajan Balamuralidhar, Niyas Kudukkil Pulloor, Koichi Kobayashi, Najib Bin Abdul Malik, Wan Shoo Cheong, Antonio Bertoletti, Neha Dikshit, Bae Hoon Kim, Bindu Sukumaran, Aylwin Ng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Optimal regulation of the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is essential for controlling bacterial infections and inflammatory disorders. Chronic NOD2 stimulation induces non-responsiveness t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460a70ca5c17b4ba00ff764ae0c637c9
http://hdl.handle.net/10044/1/50102
http://hdl.handle.net/10044/1/50102
Autor:
Nicholas Kim-Wah Yeo, Yee Sin Leo, Diane Simamarta, Angela Chow, Teck-Hui Teo, Suan-Sin Foo, Fok-Moon Lum, Aleksei Lulla, Terk-Shin Teng, Andres Merits, Keh-Chuang Chin, Esther G. L. Koh, Lisa F. P. Ng
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation; Vol 122
Journal of Clinical Investigation; Vol 122
Chikungunya virus (CHIKV) is a mosquito-borne arthralgia arbovirus that is reemergent in sub-Saharan Africa and Southeast Asia. CHIKV infection has been shown to be self-limiting, but the molecular mechanisms of the innate immune response that contro
Autor:
Wei-Xiang Sin, Joyce Jing-Yi Wong, Mickey Koh, Calvin Sum, Peng Li, Keh-Chuang Chin, Kok-Quan Ng
Publikováno v:
Blood. 117:2847-2854
Robust and rapid induction of interferon-β (IFN-β) in monocytes after pathogenic stimulation is a hallmark of innate immune responses. Here, we reveal the molecular mechanism underlying this key property that is exclusive to human blood monocytes.