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Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.

Autor: Geusz RJ; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA.; Biomedical Graduate Studies Program, University of California San Diego, La Jolla, San Diego, CA, 92037, USA., Wang A; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA., Lam DK; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA., Vinckier NK; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA., Alysandratos KD; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA., Roberts DA; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA., Wang J; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA., Kefalopoulou S; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA., Ramirez A; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA., Qiu Y; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA., Chiou J; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA.; Biomedical Graduate Studies Program, University of California San Diego, La Jolla, San Diego, CA, 92037, USA., Gaulton KJ; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA., Ren B; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA.; Ludwig Institute for Cancer Research, La Jolla, San Diego, CA, 92093-0653, USA., Kotton DN; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA, 02118, USA.; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA., Sander M; Department of Pediatrics, Pediatric Diabetes Research Center, University of California, La Jolla, San Diego, CA, 92093, USA. masander@ucsd.edu.; Department of Cellular & Molecular Medicine, University of California, La Jolla, San Diego, CA, 92093, USA. masander@ucsd.edu.; Sanford Consortium for Regenerative Medicine, La Jolla, San Diego, CA, 92093, USA. masander@ucsd.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 17; Vol. 12 (1), pp. 6636. Date of Electronic Publication: 2021 Nov 17.