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Akademický článek

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

Autor: Chang Geon Chung, Min Jee Kwon, Keun Hye Jeon, Do Young Hyeon, Myeong Hoon Han, Jeong Hyang Park, In Jun Cha, Jae Ho Cho, Kunhyung Kim, Sangchul Rho, Gyu Ree Kim, Hyobin Jeong, Jae Won Lee, TaeSoo Kim, Keetae Kim, Kwang Pyo Kim, Michael D. Ehlers, Daehee Hwang, Sung Bae Lee

Publikováno v: Cell Reports, Vol 20, Iss 2, Pp 356-369 (2017)

Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite

Externí odkaz: https://doaj.org/article/ae951938b8364c18a9c547e11381c797

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Akademický článek

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation

Publikováno v: Cell Reports, Vol 25, Iss 4, Pp 934-946.e5 (2018)

Summary: Obesity-associated metabolic alterations are closely linked to low-grade inflammation in peripheral organs, in which macrophages play a central role. Using genetic labeling of myeloid lineage cells, we show that hypothalamic macrophages norm

Externí odkaz: https://doaj.org/article/2887644aa4cd4d75b034ad52d842a9b4

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