Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kees van der Voort Maarschalk"'
Autor:
Henderik W. Frijlink, Wouter L. J. Hinrichs, Maarten A Mensink, Kees van der Voort Maarschalk
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 114:288-295
This review aims to provide an overview of current knowledge on stabilization of proteins by sugars in the solid state in relation to stress conditions commonly encountered during drying and storage. First protein degradation mechanisms in the solid
Autor:
Kees van der Voort Maarschalk, Henderik W. Frijlink, Wouter L. J. Hinrichs, Maarten A Mensink
Publikováno v:
Carbohydrate Polymers. 130:405-419
Inulin, a fructan-type polysaccharide, consists of (2 -> 1) linked beta-D-fructosyl residues (n = 2-60), usually with an (1 2) alpha-D-glucose end group. The applications of inulin and its hydrolyzed florin oligofructose (n = 2-10) are diverse. It is
Publikováno v:
Pharmaceutisch Weekblad, 43. Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP)
University of Groningen
University of Groningen
De houdbaarheid van therapeutische eiwitten kan worden verbeterd door ze samen met suikers te drogen. Kleinere en moleculair meer flexibele suikers zijn hiervoor het meest geschikt. Dit komt doordat deze suikers het best in staat zijn om tijdens drog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::12e098bb5608559246b9fb66cd272e55
https://research.rug.nl/en/publications/93bf13bb-62cd-4828-82a3-1d675d19ba34
https://research.rug.nl/en/publications/93bf13bb-62cd-4828-82a3-1d675d19ba34
Autor:
Ricardo Hooijmaijers, Tofan A Willemsz, Tien Thanh Nguyen, Kees van der Voort Maarschalk, Herman Vromans, Henderik W. Frijlink
Publikováno v:
Aaps pharmscitech, 14(1), 183-188. SPRINGER
Removal of microcrystalline cellulose agglomerates in a dry-mixing system (lactose, 100 M) predominantly occurs via abrasion. The agglomerate abrasion rate potential is estimated by the Stokes abrasion (StAbr) number of the system. The StAbrnumber eq
Publikováno v:
Journal of pharmaceutical innovation, 7(3-4), 163-173
Introduction: An early decision on the design space of a pharmaceutical could imply that some process parameter is to be held fixed during production. Therefore, the effect of such a parameter is not studied in the exploration of the design space wit
Publikováno v:
Aaps pharmscitech, 13(4), 1110-1115. SPRINGER
Absorption of drugs from the oral cavity into the mucosal tissues is typically a fast event. Dissolved drugs partition into the mucosal membranes and within minutes will reach equilibrium with drug in solution in the oral cavity. However, this does n
Autor:
Thanh T. Nguyen, Kees van der Voort Maarschalk, Thanh N. Tran, Gijs van Kessel, Henderik W. Frijlink, Tofan A Willemsz
Publikováno v:
Analytica Chimica Acta, 725, 14-21. ELSEVIER SCIENCE BV
Density-based spatial clustering of applications with noise (DBSCAN) is an unsupervised classification algorithm which has been widely used in many areas with its simplicity and its ability to deal with hidden clusters of different sizes and shapes a
Autor:
Pieter-Jan Van Bockstal, Laurens De Meyer, Maarten A Mensink, Sigrid Pieters, Thomas De Beer, Kees van der Voort Maarschalk, Henderik W. Frijlink, Wouter L. J. Hinrichs
Publikováno v:
International Journal of Pharmaceutics, 792-800. Elsevier Bedrijfsinformatie b.v.
STARTPAGE=792;ENDPAGE=800;ISSN=0378-5173;TITLE=International Journal of Pharmaceutics
INTERNATIONAL JOURNAL OF PHARMACEUTICS
STARTPAGE=792;ENDPAGE=800;ISSN=0378-5173;TITLE=International Journal of Pharmaceutics
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Sugars are often used as stabilizers of protein formulations during freeze-drying. However, not all sugars are equally suitable for this purpose. Using in-line near-infrared spectroscopy during freeze-drying, it is shown here that hydrogen bond forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6824ac7ede3c49a41b3377fe72c4fa30
https://research.rug.nl/en/publications/1d023489-2a24-4e2e-84c6-43647e41ef66
https://research.rug.nl/en/publications/1d023489-2a24-4e2e-84c6-43647e41ef66
Autor:
Thanh N. Tran, Tofan A Willemsz, Tuomas Ervasti, Kees van der Voort Maarschalk, Jarkko Ketolainen, Henderik W. Frijlink, Thanh Nguyen
Publikováno v:
Chemical Engineering Science, 66(24), 6385-6392. PERGAMON-ELSEVIER SCIENCE LTD
The coordination number is an important parameter for understanding the particulate systems, especially when agglomerated particles are present. However, experimental determination of the coordination number is not trivial. In this study, we describe
Publikováno v:
Powder Technology, 191(1-2), 72-77
Powder Technology, 191(1-2), 72-77. Elsevier
Powder Technology, 191(1-2), 72-77. Elsevier
jet milling is commonly used for reducing the particle size of active pharmaceutical ingredients. Unfortunately, this process is sometimes difficult to control as pre-existing flaws and mechanical properties affect the particle fracture behaviour in