Effect of long-term storage in biobanks on cerebrospinal fluid biomarker Aβ1-42, T-tau, and P-tau values

Autor: Eline A.J. Willemse, Charlotte E. Teunissen, Wiesje M. van der Flier, Kees W.J. van Uffelen

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 8, Iss 1, Pp 45-50 (2017)
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8, 45-50. Elsevier BV
Willemse, E A J, van Uffelen, K W J, van der Flier, W M & Teunissen, C E 2017, ' Effect of long-term storage in biobanks on cerebrospinal fluid biomarker Aβ 1-42, T-tau, and P-tau values ', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 8, pp. 45-50 . https://doi.org/10.1016/j.dadm.2017.03.005

Introduction We studied the effect of long-term storage at −80°C on cerebrospinal fluid (CSF) biomarker levels. Our approach assumed consistency of mean biomarker levels in a homogenous Alzheimer's disease patient cohort over time. Methods We sele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9b6e0c9f9fa6c8b17206159ec00579
https://doi.org/10.1016/j.dadm.2017.03.005

How to handle adsorption of cerebrospinal fluid amyloid-β (142) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ_{42}$/Aβ_{40}$ ratio

Autor: Eline A.J. Willemse, Kees W.J. van Uffelen, Britta Brix, Sebastiaan Engelborghs, Hugo Vanderstichele, Charlotte E. Teunissen

Publikováno v: Alzheimer's & dementia
Alzheimer's and Dementia, 13(8), 885-892. Elsevier
Willemse, E, van Uffelen, K, Brix, B, Engelborghs, S, Vanderstichele, H & Teunissen, C 2017, ' How to handle adsorption of cerebrospinal fluid amyloid β (1–42) in laboratory practice? Identifying problematic handlings and resolving the issue by use of the Aβ 42 /Aβ 40 ratio ', Alzheimer's and Dementia, vol. 13, no. 8, pp. 885-892 . https://doi.org/10.1016/j.jalz.2017.01.010

Introduction We aimed to investigate factors defining amyloid β (1–42) (Aβ1–42) adsorption during preanalytical workup of cerebrospinal fluid (CSF). Methods CSF was transferred to new tubes ≤4 times. Variables tested were different polypropyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a7732c33fd99418778dfca57694300
https://hdl.handle.net/10067/1407590151162165141

P1‐201: Quality Indicators of Pre‐Analytical Variation in Cerebrospinal Fluid Detected with Aptamer Screening

Autor: Kees W.J. van Uffelen, Mark A. van de Wiel, Charlotte E. Teunissen, Lev Yener, Eline A.J. Willemse

Publikováno v: Alzheimer's & Dementia. 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02fc2974e26e26cd91bcad3297624dd2
https://doi.org/10.1016/j.jalz.2016.06.949