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Akademický článek

Resistance to Platinum-Containing Chemotherapy in Testicular Germ Cell Tumors Is Associated with Downregulation of the Protein Kinase SRPK1

Autor: Paul W. Schenk, Hans Stoop, Carsten Bokemeyer, Frank Mayer, Gerrit Stoter, J. Wolter Oosterhuis, Erik Wiemer, Leendert H.J. Looijenga, Kees Nooter

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 4, Pp 297-301 (2004)

Male germ cell tumors (GCTs) are extremely sensitive to platinum-containing chemotherapy, with only 10% of patients showing therapy resistance. However, the biological basis of the high curability of disseminated GCTs by chemotherapy is still unknown

Externí odkaz: https://doaj.org/article/72cf020a20f24710ad08aec719857499

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Attempts to Transform Murine Hemopoietic Cells by Rauscher Leukemia Virus

Autor: G. J. van den Engh, C. Zurcher, Kees Nooter, A. M. Aarssen, J. Brinkhof, P. Bentvelzen

Primary Rauscher leukemia virus (RLV)-induced myeloid leukemias can produce many small clones in agar in the absence of a factor needed for the proliferation of normal myeloid cells. It seems that leukemic cells can more efficiently utilize the small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b210dee6b861f4cb4a2da4d79a01c5ed
https://doi.org/10.1159/000397531

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Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib

Autor: Sharyn D. Baker, Alex Sparreboom, Gunther Guetens, Allan T. van Oosterom, Ernst A. de Bruijn, Ron H.N. van Schaik, Susan E. Bates, Hans Prenen, Jaap Verweij, Kees Nooter, Erin R. Gardner, William D. Figg, Herman Burger, Floris A. de Jong

Publikováno v: Clinical pharmacology and therapeutics
Clinical Pharmacology & Therapeutics, 80(2), 192-201. Wiley-Blackwell

Objective: Our objective was to explore the relationships between imatinib pharmacokinetics and 9 allelic variants in 7 genes coding for adenosine triphosphate–binding cassette transporters (ABCB1 and ABCG2) and enzymes (cytochrome P450 [CYP] 2C9,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3b236fc751970f545a2f2e675da96d
https://doi.org/10.1016/j.clpt.2006.05.003

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Evaluation of an alternate dosing strategy for cisplatin in patients with extreme body surface area values

Autor: Felix E. de Jongh, Alex Sparreboom, Kees Nooter, Jaap Verweij, Walter J. Loos, Desirée M. Van Zomeren, Ronald de Wit, Gerrit Stoter

Publikováno v: Journal of Clinical Oncology, 24(10), 1499-1506. American Society of Clinical Oncology

Purpose The majority of cytotoxic drugs for adults are dosed based on body surface area (BSA), aiming to reduce interpatient variability in drug exposure. We prospectively studied the usefulness of BSA-based dosing of cisplatin in patients at extreme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372f3d89e5c4e0ab51b30c3e5cb2b85b
https://doi.org/10.1200/JCO.2005.03.0056

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Molecular profiling of platinum resistant ovarian cancer

Autor: Iris L. van Staveren, Els M.J.J. Berns, Maurice P.H.M. Jansen, Paul N. Span, Marion E. Meijer-van Gelder, Maria E. L. van der Burg, Kees Nooter, Leon F. A. G. Massuger, Gerrit Stoter, Fired C. G. J. Sweep, Jozien Helleman, Patricia C. Ewing

Publikováno v: International Journal of Cancer. 118:1963-1971

The aim of this study is to discover a gene set that can predict resistance to platinum-based chemotherapy in ovarian cancer. The study was performed on 96 primary ovarian adenocarcinoma specimens from 2 hospitals all treated with platinum-based chem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba25b49ae167d2665f98169db56ca6c4
https://doi.org/10.1002/ijc.21599

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Activating mutations in c-KIT and PDGFRα are exclusively found in gastrointestinal stromal tumors and not in other tumors overexpressing these imatinib mesylate target genes

Autor: Hans P de Schipper, Harry F G M van den Ingh, Erik A.C. Wiemer, Erwin van der Harst, Hans van Tol, Alex M de Bruin, Wolter Oosterhuis, Kees Nooter, Johan M. Kros, Herman Burger, Michael A. den Bakker

Publikováno v: Scopus-Elsevier
Cancer Biology & Therapy, 4(11), 1270-1274. Landes Bioscience

Previous studies have shown that Imatinib mesylate (Gleevec), a selective tyrosine kinase inhibitor of c-KIT and platelet-derived growth factor receptors (PDGFR), is highly effective in c-KIT/CD117-positive gastrointestinal stromal tumors (GIST), esp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7392b2c23e04d36655b15fa3534126
https://doi.org/10.4161/cbt.4.11.2253

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Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2

Autor: Alex Sparreboom, William D. Figg, Erin R. Lepper, Milin Acharya, Jaap Verweij, Kees Nooter

Publikováno v: Pharmacogenomics, 6(2), 115-138. Future Medicine Ltd.

ATP-binding cassette (ABC) genes play a role in the resistance of malignant cells to anticancer agents. The ABC gene products, including ABCB1 (P-glycoprotein) and ABCG2 (breast cancer-resistance protein [BCRP], mitoxantrone-resistance protein [MXR],

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9df82240d24bce66e7d7aede49d102a
https://doi.org/10.1517/14622416.6.2.115

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Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1

Autor: J. Wolter Oosterhuis, Kees Nooter, Paul W. Schenk, Frank Mayer, Hans Stoop, Erik A.C. Wiemer, Leendert H. J. Looijenga, Carsten Bokemeyer, Gerrit Stoter

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 4, Pp 297-301 (2004)
Neoplasia, 6(4), 297-301. Neoplasia Press

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b943c4ae8a3b91657951d301c15c93
https://doi.org/10.1593/neo.03406

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Randomized Cross-Over Evaluation of Body-Surface Area–Based Dosing Versus Flat-Fixed Dosing of Paclitaxel

Autor: Kees Nooter, Alex Sparreboom, Jaap Verweij, Carolien H. Smorenburg, M. Bontenbal, Gerrit Stoter

Publikováno v: Journal of Clinical Oncology, 21, 197-202. American Society of Clinical Oncology

Purpose: Despite dose calculation using body-surface area (BSA), pharmacokinetics of most anticancer drugs show wide interindividual variability. In this study, we evaluated the role of BSA in paclitaxel disposition. Patients and Methods: Paclitaxel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffee9a4e12bf0eb487ff65803b27ad84
https://doi.org/10.1200/jco.2003.01.058

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Lack of c-kit exon 11 activating mutations in c-KIT/CD117-positive SCLC tumour specimens

Autor: M A den Bakker, Kees Nooter, Jaap Verweij, Gerrit Stoter, Herman Burger

Publikováno v: European Journal of Cancer, 39, 793-799. Elsevier Ltd.

Previous studies have shown that STI571, a selective tyrosine kinase inhibitor of c-KIT, is highly effective in c-KIT/CD117-positive gastrointestinal stromal tumours (GIST), especially those that have activating mutations in the c-kit exon 11 that en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350e499b1307c1048628070d7833435
https://hdl.handle.net/1765/61860

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