Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Kees Hovingh"'
Autor:
Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M. Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F. Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G. Panayiotou, N. Charlotte Onland-Moret, Yvonne T. van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J. Wareham, Claudia Langenberg, Robert A. Scott, Jian’an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E. Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S. Carrell, Catherine A. McCarty, Kirchner H. Lester, Eric B. Larson, David R. Crosslin, Mariza de Andrade, Dan M. Roden, Joshua C. Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O’Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M. Abdullah Said, Ruben N. Eppinga, Niek Verweij, Harold Snieder, Lifelines Cohort authors, Tim Christen, D. O. Mook-Kanamori, the ICBP Consortium, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M. Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P. Pell, Tom Meade, Ingrid E. Christophersen, Anke H. Maitland-van der Zee, Ekaterina V. Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L. Bots, Diederick E. Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C. Hopewell, Sudha Seshadri, the METASTROKE Consortium of the ISGC, Caroline Dale, Rui Providencia E. Costa, Paul M. Ridker, Daniel I. Chasman, Alex P. Reiner, Marylyn D. Ritchie, Leslie A. Lange, Alex J. Cornish, Sara E. Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W. Asselbergs, Riyaz S. Patel, Brendan J. Keating, Naveed Sattar, Richard Houlston, Juan P. Casas, Aroon D. Hingorani
Publikováno v:
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods Published and individual participant level data (300,000+
Externí odkaz:
https://doaj.org/article/6496ec7ef17e440a938a2e70da19e20c
Autor:
Jordan M. Kraaijenhof, Héléne T. Cronjé, G. Kees Hovingh, Nick S. Nurmohamed, Dipender Gill, Loukas Zagkos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Externí odkaz:
https://doaj.org/article/ce4afd7541434e509f54df4e4fe15723
Autor:
Cheryl L. Wellington, Yu-Zhou Yang, Stephen Zhou, Susanne M. Clee, Bing Tan, Kenichi Hirano, Karin Zwarts, Anita Kwok, Allison Gelfer, Michel Marcil, Scott Newman, Kirsten Roomp, Roshni Singaraja, Jennifer Collins, Lin-Hua Zhang, Albert K. Groen, Kees Hovingh, Alison Brownlie, Sherrie Tafuri, Jacques Genest, Jr., John J.P. Kastelein, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 11, Pp 1939-1949 (2002)
Mutations in ABCA1 uniformly decrease plasma HDL-cholesterol (HDL-C) and reduce cholesterol efflux, yet different mutations in ABCA1 result in different phenotypic effects in heterozygotes. For example, truncation mutations result in significantly lo
Externí odkaz:
https://doaj.org/article/a28f9b5721114433ab9269392ebf98fd
Autor:
Khurram Nasir, Reed Mszar, Miguel Cainzos-Achirica, Gowtham R. Grandhi, Tycho R. Tromp, Rodrigo Alonso, Márcio S. Bittencourt, Eric Bruckert, José Luis Díaz-Díaz, Antonio Gallo, G. Kees Hovingh, Marcio H. Miname, Ovidio Muñiz-Grijalvo, Jing Pang, Leopoldo Perez de Isla, Eric J.G. Sijbrands, Gerald F. Watts, Pedro Mata, Raul D. Santos
Publikováno v:
American Journal of Preventive Cardiology, Vol 17, Iss , Pp 100611- (2024)
Objectives: Individuals with familial hypercholesterolemia (FH) are at an increased risk for coronary artery disease (CAD). While prior research has shown variability in coronary artery calcification (CAC) among those with FH, studies with small samp
Externí odkaz:
https://doaj.org/article/02c543cadbc747008f4f6ac5cb02c969
Autor:
Suthesh Sivapalaratnam, Hanneke Basart, Nicholas A Watkins, Stepanie Maiwald, Augusto Rendon, Unni Krishnan, Brigitte M Sondermeijer, Esther E Creemers, Sara J Pinto-Sietsma, Kees Hovingh, Willem H Ouwehand, John J P Kastelein, Alison H Goodall, Mieke D Trip
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32166 (2012)
The burden of cardiovascular disease (CVD) cannot be fully addressed by therapy targeting known pathophysiological pathways. Even with stringent control of all risk factors CVD events are only diminished by half. A number of additional pathways proba
Externí odkaz:
https://doaj.org/article/951b2462e9674933a015ecc2ba6fd567
Autor:
Shirin Ibrahim, Nick S. Nurmohamed, Didier Collard, Anouk de Weger, G. Kees Hovingh, Bert‐Jan H. van den Born, Laurens F. Reeskamp, Erik S. G. Stroes, Tom F. Brouwer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 22 (2023)
Background Medication nonadherence contributes to poor health outcomes but remains challenging to identify. This study assessed the association between self‐rated adherence and systolic blood pressure, low‐density lipoprotein cholesterol levels,
Externí odkaz:
https://doaj.org/article/5518a4fd1e424e2bbc5c5fd76e2a17e4
Autor:
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 21 (2023)
Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase. It is currently unknown whether and to which lipoproteins ANG
Externí odkaz:
https://doaj.org/article/bafeced5a2c34d4aab76891c406e105f
Autor:
Héléne T. Cronjé, Ville Karhunen, G. Kees Hovingh, Ken Coppieters, Jens O. Lagerstedt, Michael Nyberg, Dipender Gill
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background C-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the prevention and treatment of cardiovascular disease (CVD). This study aimed to explore the effect
Externí odkaz:
https://doaj.org/article/0d9080e5d8094a21b18b925771ec0af9
Autor:
Darren K. McGuire, Rodica P. Busui, John Deanfield, Silvio E. Inzucchi, Johannes F. E. Mann, Nikolaus Marx, Sharon L. Mulvagh, Neil Poulter, Mads D. M. Engelmann, G. Kees Hovingh, Maria Sejersten Ripa, Mette Gislum, Kirstine Brown‐Frandsen, John B. Buse
Publikováno v:
Diabetes, Obesity and Metabolism. Wiley-Blackwell
Diabetes, obesity and metabolism 25(7), 1932-1941 (2023). doi:10.1111/dom.15058
Diabetes, obesity and metabolism 25(7), 1932-1941 (2023). doi:10.1111/dom.15058
Aim: To describe the design of the SOUL trial (Semaglutide cardiOvascular oUtcomes triaL) and the baseline clinical data of its participants. Materials and methods: In SOUL, the effects of oral semaglutide, the first oral glucagon-like peptide-1 rece
Autor:
Stephen Burgess, Amy M. Mason, Andrew J. Grant, Eric A.W. Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G. Haynes, G. Kees Hovingh, Lotte Bjerre Knudsen, John C. Whittaker, Dipender Gill
Publikováno v:
American journal of human genetics. 110(2):195-214
Evidence on the validity of drug targets from randomized trials is reliable but typically expensive and slow to obtain. In contrast, evidence from conventional observational epidemiological studies is less reliable because of the potential for bias f