The streptococcal phase-variable type I restriction modification system SsuCC20p dictates the methylome of Streptococcus suis impacting the transcriptome and virulence in a zebrafish larvae infection model

Autor: Thomas J. Roodsant, Boas van der Putten, Jaime Brizuela, Jordy P. M. Coolen, Tim J. H. Baltussen, Kim Schipper, Yvonne Pannekoek, Kees C. H. van der Ark, Constance Schultsz

Publikováno v: mBio, Vol 15, Iss 1 (2024)

ABSTRACTPhase-variable type I restriction modification (RM) systems are epigenetic regulatory systems that have been identified in numerous human bacterial pathogens. We previously showed that an emerging zoonotic lineage of Streptococcus suis acquir

Externí odkaz: https://doaj.org/article/139c363bb5a14f29b9d0177836416bdf

More than just a gut feeling: constraint-based genome-scale metabolic models for predicting functions of human intestinal microbes

Autor: Kees C. H. van der Ark, Ruben G. A. van Heck, Vitor A. P. Martins Dos Santos, Clara Belzer, Willem M. de Vos

Publikováno v: Microbiome, Vol 5, Iss 1, Pp 1-13 (2017)

Abstract The human gut is colonized with a myriad of microbes, with substantial interpersonal variation. This complex ecosystem is an integral part of the gastrointestinal tract and plays a major role in the maintenance of homeostasis. Its dysfunctio

Externí odkaz: https://doaj.org/article/d2050376bc0b4867bc399f89db6d0134

Identification of

Autor: Thomas J, Roodsant, Boas C L, Van Der Putten, Sara M, Tamminga, Constance, Schultsz, Kees C H, Van Der Ark

Publikováno v: Virulence
article-version (VoR) Version of Record

Streptococcus suis is an emerging zoonotic pathogen. Over 100 putative virulence factors have been described, but it is unclear to what extent these virulence factors could contribute to zoonotic potential of S. suis. We identified all S. suis virule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f29cc85d7ca442c858c36718db5b5ae3
https://pubmed.ncbi.nlm.nih.gov/34666617

Model‐driven design of a minimal medium for Akkermansia muciniphila confirms mucus adaptation

Autor: Kees C. H. van der Ark, Willem M. de Vos, Peter J. Schaap, Steven Aalvink, Maria Suarez-Diez, Clara Belzer

Publikováno v: Microbial Biotechnology
Microbial Biotechnology 11 (2018) 3
Microbial Biotechnology, 11(3), 476-485

The abundance of the human intestinal symbiont Akkermansia muciniphila has found to be inversely correlated with several diseases, including metabolic syndrome and obesity. A.muciniphila is known to use mucin as sole carbon and nitrogen source. To st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f16becc93a1ee41d92dbf4e8d570a
http://europepmc.org/articles/PMC5902328

Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations

Autor: Constance Schultsz, Daisy I. Picavet, Norbert Stockhofe-Zurwieden, Hilde E. Smith, Henk J. Wisselink, Niels Willemse, Kees C. H. van der Ark, Astrid de Greeff, Conny van Solt-Smits

Publikováno v: Scientific Reports, 9(1)
Scientific Reports 9 (2019) 1
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific reports, 9(1):15429. Nature Publishing Group

Streptococcus suis is a porcine pathogen, causing severe invasive infections. S. suis serotype 9 is increasingly causing disease in Dutch and Chinese pig herds, but it is unknown whether all serotype 9 isolates are equally virulent and markers that c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5eccbdf45338ee7976001f5a82c939
https://research.wur.nl/en/publications/clonal-expansion-of-a-virulent-istreptococcus-suisi-serotype-9-li