KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands.

Autor: Fan L; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Lesser AF; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Sweet DR; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Keerthy KS; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA., Lu Y; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA.; Charles River Laboratories, Ashland, OH 44805, USA., Chan ER; Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA., Vinayachandran V; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA., Ilkayeva O; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Das T; Division of Biology and Medicine, Warren Alpert Medical School of Brown University, Providence, IR 02903, USA., Newgard CB; Sarah W. Stedman Nutrition and Metabolism Center and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.; Department of Medicine and Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Jain MK; Division of Biology and Medicine, Warren Alpert Medical School of Brown University, Providence, IR 02903, USA.

Publikováno v: IScience [iScience] 2022 Oct 08; Vol. 25 (11), pp. 105292. Date of Electronic Publication: 2022 Oct 08 (Print Publication: 2022).

Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation.

Autor: Sweet DR; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Vasudevan NT; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Fan L; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA., Booth CE; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Keerthy KS; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Liao X; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Vinayachandran V; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Takami Y; Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan., Tugal D; Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA., Sharma N; DBPAP/OVRR/CBER, Food and Drug Administration, Silver Spring, MD, USA., Chan ER; Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA., Zhang L; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Qing Y; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; National Center for Regenerative Medicine, Seidman Cancer Center, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA., Gerson SL; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; National Center for Regenerative Medicine, Seidman Cancer Center, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, OH, USA., Fu C; Department of Genetics and Genome Sciences, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Wynshaw-Boris A; Department of Genetics and Genome Sciences, Case Western Reserve University, and University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Sangwung P; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA., Nayak L; Division of Hematology and Oncology, University Hospitals Cleveland Medical Center, Cleveland, USA., Holvoet P; Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Matoba K; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Lu Y; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.; Charles River Laboratories, Ashland, OH, USA., Zhou G; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Jain MK; Case Cardiovascular Research Institute, Case Western Reserve University, and Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. mxj84@case.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Nov 18; Vol. 11 (1), pp. 5872. Date of Electronic Publication: 2020 Nov 18.