Urm1, not quite a ubiquitin-like modifier?

Autor: Lars Kaduhr, Cindy Brachmann, Keerthiraju Ethiraju Ravichandran, James D. West, Sebastian Glatt, Raffael Schaffrath

Publikováno v: Microbial Cell, Vol 8, Iss 11, Pp 256-261 (2021)

Ubiquitin related modifier 1 (Urm1) is a unique eukaryotic member of the ubiquitin-fold (UbF) protein family and conserved from yeast to humans. Urm1 is dual-functional, acting both as a sulfur carrier for thiolation of tRNA anticodons and as a prote

Externí odkaz: https://doaj.org/article/0d80428e3e4f429ba163e7e80e12d319

E2/E3-independent ubiquitin-like protein conjugation by Urm1 protects the proteome under oxidative stress

Autor: Keerthiraju Ethiraju Ravichandran, Kaduhr, Lars, Kwasna, Dominika, Glatt, Sebastian, Perez, Sebastian Guzman, Leidel, Sebastian, Brachmann, Cindy, Mikołaj Sokołowski, Rościsław Krutyhołowa, Schaffrath, Raffael, Jankowska, Urszula, Przemyslaw Grudnik, Bozena Skupien-Rabian, Wilk, Piotr, Shvetsova, Ekaterina, Kösters, Manuel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f1aad7978397128e6c8014a640ff926

Molecular basis for the bifunctional Uba4-Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation

Autor: Urszula Jankowska, Sebastian A. Leidel, Mikołaj Sokołowski, Martin Termathe, Przemyslaw Grudnik, Sebastian Glatt, Rościsław Krutyhołowa, Marta Pabis, Keerthiraju Ethiraju Ravichandran, Sandra D. Kienast

Publikováno v: The EMBO Journal
Pabis, Marta; Termathe, Martin; Ravichandran, Keerthiraju E; Kienast, Sandra D.; Krutyhołowa, Rościsław; Sokołowski, Mikołaj; Jankowska, Urszula; Grudnik, Przemysław; Leidel, Sebastian A.; Glatt, Sebastian (2020). Molecular basis for the bifunctional Uba4–Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation. The EMBO journal, 39(19) EMBO Press 10.15252/embj.2020105087

The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin‐related modifier 1 (Urm1) pathway is responsible for the synthesis of 2‐thiolated wobble uridine (U34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f2b43067fd1d0f54b5a0b86866d104
https://pubmed.ncbi.nlm.nih.gov/32901956

Roles of Elongator Dependent tRNA Modification Pathways in Neurodegeneration and Cancer

Autor: Keerthiraju Ethiraju Ravichandran, Alexander Hammermeister, Roland Klassen, Harmen Hawer, Raffael Schaffrath, Sebastian Glatt

Publikováno v: Genes
Genes, Vol 10, Iss 1, p 19 (2018)

Transfer RNA (tRNA) is subject to a multitude of posttranscriptional modifications which can profoundly impact its functionality as the essential adaptor molecule in messenger RNA (mRNA) translation. Therefore, dynamic regulation of tRNA modification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80b2e00f3c459233c6c3e501672ed7a
http://europepmc.org/articles/PMC6356722