Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Keerthana Chithanathan"'
Autor:
Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L. Elliot Hong, Yunlong Tan, Li Tian
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrophages contribute to s
Externí odkaz:
https://doaj.org/article/3688731ab7f54d3e93ad89bc88e2f32a
Autor:
Reddy Peera Kommaddi, Aditi Verma, Graciela Muniz-Terrera, Vivek Tiwari, Keerthana Chithanathan, Latha Diwakar, Ruturaj Gowaikar, Smitha Karunakaran, Palash Kumar Malo, Neill R. Graff-Radford, Gregory S. Day, Christoph Laske, Jonathan Vöglein, Georg Nübling, Takeshi Ikeuchi, Kensaku Kasuga, the Dominantly Inherited Alzheimer Network (DIAN), Vijayalakshmi Ravindranath
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Women carry a higher burden of Alzheimer’s disease (AD) compared to men, which is not accounted entirely by differences in lifespan. To identify the mechanisms underlying this effect, we investigated sex-specific differences in the progres
Externí odkaz:
https://doaj.org/article/2bfd52fdcfe340b289a3a6a570cfb8d0
Autor:
Fang-Ling Xuan, Ling Yan, Yanli Li, Fengmei Fan, Hu Deng, Mengzhuang Gou, Keerthana Chithanathan, Indrek Heinla, Liang Yuan, Kadri Seppa, Alexander Zharkovsky, Anti Kalda, L. Elliot Hong, Guo-Fu Hu, Yunlong Tan, Li Tian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Stress is a trigger for the development of psychiatric disorders. However, how stress trait differs in schizophrenia patients is still unclear. Stress also induces and exacerbates immune activation in psychiatric disorders. Plexins (Plxn) and its lig
Externí odkaz:
https://doaj.org/article/e80d7331dc744fa08484c69174c8f6e7
Autor:
Keerthana Chithanathan, Monika Jürgenson, Mithu Guha, Ling Yan, Tamara Žarkovskaja, Martin Pook, Nathaniel Magilnick, Mark P. Boldin, Ana Rebane, Li Tian, Alexander Zharkovsky
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b (miR-146a/b), both of which are known to suppress immune responses in a variety of conditions. Here, we studied how constitutive deficiency of miR-146b (Mir146b-/-) affects
Externí odkaz:
https://doaj.org/article/28cdd8f7d6cb4b09bc5d34cb564b556a
Autor:
Latha Diwakar, Ruturaj Gowaikar, Keerthana Chithanathan, Barathan Gnanabharathi, Deepika Singh Tomar, Vijayalakshmi Ravindranath
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cerebrovascular lesions seen as white matter hyperintensity in MRI of elderly population caused due to micro-infracts and micro-bleeds contributes to vascular dementia. Such vascular insult caused by impairment in blood flow to specific area
Externí odkaz:
https://doaj.org/article/74d9ee203fc4469cbc7f42df2d7852c3
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The coronavirus disease 2019 (COVID-19) pandemic has generated a lot of stress and anxiety among not only infected patients but also the general population across the globe, which disturbs cerebral immune homeostasis and potentially exacerbates the S
Externí odkaz:
https://doaj.org/article/e284ee987e3d4837b65950a904607958
Publikováno v:
Biology, Vol 11, Iss 6, p 938 (2022)
Anxiety is a known comorbidity and risk factor for conversion to neuroinflammation-mediated dementia in patients with Alzheimer’s disease (AD). Here, we investigated if anxiety occurred as an early endophenotype of mutant familial AD (5 × FAD) mal
Externí odkaz:
https://doaj.org/article/c7b9b10a7fd749e7b9527bbc84f48370
Autor:
Keerthana Chithanathan, Kelli Somelar, Monika Jürgenson, Tamara Žarkovskaja, Kapilraj Periyasamy, Ling Yan, Nathaniel Magilnick, Mark P. Boldin, Ana Rebane, Li Tian, Alexander Zharkovsky
Publikováno v:
Cells, Vol 11, Iss 13, p 2002 (2022)
The miR-146 family consists of two microRNAs (miRNAs), miR-146a and miR-146b, which are both known to suppress a variety of immune responses. Here in this study, we show that miR-146b is abundantly expressed in neuronal cells, while miR-146a is mainl
Externí odkaz:
https://doaj.org/article/f0b902e15dbd449e92e550f49f74d86f
Autor:
Maria Piirsalu, Keerthana Chithanathan, Mohan Jayaram, Tanel Visnapuu, Kersti Lilleväli, Mihkel Zilmer, Eero Vasar
Publikováno v:
Cells, Vol 11, Iss 6, p 1032 (2022)
Many studies have demonstrated significant mouse-strain-specific differences in behavior and response to pathogenic and pharmacological agents. This study seeks to characterize possible differences in microglia activation and overall severity of neur
Externí odkaz:
https://doaj.org/article/f7bdba2910a2480ead1f712ea894d3e3
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulating evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and
Externí odkaz:
https://doaj.org/article/16a031299d3349dcad49759008d6d978