Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Keerang Park"'
Autor:
Seo Yun Moon, Hee Jong Kim, Jin Kwon Kim, Jin Kim, Jun-Sub Choi, So-Yoon Won, Keerang Park, Steven Hyun Seung Lee
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0305466 (2024)
In previous animal model studies, we demonstrated the potential of rAAV2-sVEGFRv-1, which encodes a truncated variant of the alternatively spliced soluble version of VEGF receptor-1 (VEGFR1), as a human gene therapy for age-related macular degenerati
Externí odkaz:
https://doaj.org/article/9b95eb3225e041e1aaefc64fb162c2d0
Autor:
Seho Cha, Won‐il Seo, Ha‐Na Woo, Hee Jong Kim, Steven Hyun Seung Lee, Jin Kim, Jun‐Sub Choi, Keerang Park, Joo Yong Lee, Beom Jun Lee, Heuiran Lee
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 71-81 (2022)
Expanding on previous demonstrations of the therapeutic effects of adeno‐associated virus (AAV) carrying small‐hairpin RNA (shRNA) in downregulating the mechanistic target of rapamycin (mTOR) in in vivo retinal vascular disorders, vascular endoth
Externí odkaz:
https://doaj.org/article/f4c42c99642440b5a60a7cc70f9bfdbe
Autor:
Steven Hyun Seung Lee, Joo Yong Lee, Jun-Sub Choi, Hee Jong Kim, Jin Kim, Seho Cha, Kyoung Jin Lee, Ha-Na Woo, Keerang Park, Heuiran Lee
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269951 (2022)
In addition to laser photocoagulation, therapeutic interventions for diabetic retinopathy (DR) have heretofore consisted of anti-VEGF drugs, which, besides drawbacks inherent to the treatments themselves, are limited in scope and may not fully addres
Externí odkaz:
https://doaj.org/article/e164b88d9f354d678fd705643f2be3cd
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 55-66 (2019)
Adeno-associated viruses (AAVs) are currently the most popular vector platform technology for ocular gene therapy. While transduction efficiency and tropism of intravitreally administered AAV has been fairly well established in various retinal condit
Externí odkaz:
https://doaj.org/article/18800f34c992434aa947bc45d6b194de
Autor:
Si Hyung Lee, Ye Seul Kim, Seung Kwan Nah, Hee Jong Kim, Ha Yan Park, Jin Young Yang, Keerang Park, Tae Kwann Park
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 90-98 (2018)
Adeno-associated virus (AAV) vector is a promising platform technology for ocular gene therapy. Recently clinical successes to treat choroidal neovascularization (CNV) in wet type age-related macular degeneration have been reported. However, because
Externí odkaz:
https://doaj.org/article/fc70f61e14e34c35a1e7407e9bdcafdc
Autor:
Tae Kwann Park, Si Hyung Lee, Jun Sub Choi, Seung Kwan Nah, Hee Jong Kim, Ha Yan Park, Heuiran Lee, Steven Hyun Seung Lee, Keerang Park
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 26-35 (2017)
Choroidal neovascularization (CNV) is the defining characteristic feature of the wet subtype of age-related macular degeneration (AMD) and may result in irreversible blindness. Based on anti-vascular endothelial growth factor (anti-VEGF), the current
Externí odkaz:
https://doaj.org/article/2534eab79ff04c05b40b8bc6a44a10c0
Publikováno v:
Mediators of Inflammation, Vol 2, Iss 4, Pp 271-277 (1993)
Tumour necrosis factor (TNF) inhibits the accumulation of acetyl CoA carboxylase (ACC) mRNA by decreasing the rate of ACC gene transcription. The ACC mRNA species found in 30A5 cells are generated from promoter II and TNF inhibits the accumulation of
Externí odkaz:
https://doaj.org/article/70d4dd0aea514ab8a6f2170db8e5b3c5
Autor:
Heuiran Lee, Won-Il Seo, Steven Hyun Seung Lee, Jun-Sub Choi, Hee Jong Kim, Ha-Na Woo, Joo Yong Lee, Jin Kim, Keerang Park, Beom Jun Lee, Seho Cha
Publikováno v:
FEBS Open Bio, Vol 12, Iss 1, Pp 71-81 (2022)
FEBS Open Bio
FEBS Open Bio
Expanding on previous demonstrations of the therapeutic effects of adeno‐associated virus (AAV) carrying small‐hairpin RNA (shRNA) in downregulating the mechanistic target of rapamycin (mTOR) in in vivo retinal vascular disorders, vascular endoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c343345145798558faec98096fba4c
https://doaj.org/article/f4c42c99642440b5a60a7cc70f9bfdbe
https://doaj.org/article/f4c42c99642440b5a60a7cc70f9bfdbe
Autor:
Steven Hyun Seung Lee, Joo Yong Lee, Im Kyeung Kang, Jun-Sub Choi, Hee Jong Kim, Jin Kim, Seho Cha, Kyoung Jin Lee, Ha-Na Woo, Keerang Park, Heuiran Lee
Publikováno v:
Advances in Cell and Gene Therapy.
In addition to laser photocoagulation, currently used therapeutic interventions for diabetic retinopathy (DR) include relatively short-lived anti-VEGF drugs targeting vascular endothelial growth factor (VEGF). The latter requires frequent administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d449817254bb5f6012bc68a577f08880
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 55-66 (2019)
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 55-66 (2019)
Adeno-associated viruses (AAVs) are currently the most popular vector platform technology for ocular gene therapy. While transduction efficiency and tropism of intravitreally administered AAV has been fairly well established in various retinal condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9193e50f135f5f6fcf497caadd3e9cfc
http://europepmc.org/articles/PMC6330514
http://europepmc.org/articles/PMC6330514