Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Keenan A. Lacey"'
Autor:
Amelia St. John, Andrew I. Perault, Sabrina I. Giacometti, Alexis G. Sommerfield, Ashley L. DuMont, Keenan A. Lacey, Xuhui Zheng, Julia Sproch, Chris Petzold, Kristen Dancel-Manning, Sandra Gonzalez, Medini Annavajhala, Colleen Beckford, Nathalie Zeitouni, Feng-Xia Liang, Harm van Bakel, Bo Shopsin, Anne-Catrin Uhlemann, Alejandro Pironti, Victor J. Torres
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Nosocomial infections caused by multidrug-resistant (MDR) Enterobacter cloacae complex (ECC) pathogens are on the rise. However, the virulence strategies employed by these pathogens remain elusive. Here, we study the interaction of ECC clini
Externí odkaz:
https://doaj.org/article/d3aff886dd104f129b126519af1d6e50
Autor:
Xuhui Zheng, Gerben Marsman, Keenan A. Lacey, Jessica R. Chapman, Christian Goosmann, Beatrix M. Ueberheide, Victor J. Torres
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The pathogen Staphylococcus aureus releases several pore-forming toxins, termed leukocidins, that kill immune cells. Here, Zheng et al. show that the retention of a leukocidin on bacterial cells and its release are modulated by lipoteichoic acid and
Externí odkaz:
https://doaj.org/article/5b83eef527514fa19ea34ec32cc64ae8
Autor:
Keenan A. Lacey, Sandra Gonzalez, Frank Yeung, Gregory Putzel, Magdalena Podkowik, Alejandro Pironti, Bo Shopsin, Ken Cadwell, Victor J. Torres
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital-acquired pneumonia. To better manage patients with MRSA pneumonia, we require a greater understanding of the host-pathogen interactions during in
Externí odkaz:
https://doaj.org/article/78baa33b38514ddba6a13b6964fd8838
Publikováno v:
Pathogens, Vol 5, Iss 1, p 22 (2016)
Staphylococcus aureus (S. aureus) causes the vast majority of skin and soft tissue infections (SSTIs) in humans. S. aureus has become increasingly resistant to antibiotics and there is an urgent need for new strategies to tackle S. aureus infections.
Externí odkaz:
https://doaj.org/article/bc125a7c446a467ab8aec903e4c929d2
Autor:
Keenan A. Lacey, Lee Serpas, Sohei Makita, Yueyang Wang, Ali Rashidfarrokhi, Chetna Soni, Sandra Gonzalez, Andre Moreira, Victor J. Torres, Boris Reizis
Publikováno v:
Journal of Experimental Medicine. 220
Extracellular DNase DNASE1L3 maintains tolerance to self-DNA in humans and mice, whereas the role of its homolog DNASE1 remains controversial, and the overall function of secreted DNases in immunity is unclear. We report that deletion of murine DNASE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e632011ce13eb175dfcd18b7210b57
https://doi.org/10.1084/jem.20221086
https://doi.org/10.1084/jem.20221086
Autor:
Denis G. Loredan, Joseph C. Devlin, Keenan A. Lacey, Nina Howard, Ze Chen, Erin E. Zwack, Jian-Da Lin, Kelly V. Ruggles, Kamal M. Khanna, Victor J. Torres, P’ng Loke
Publikováno v:
bioRxiv
Our previous studies identified a population of stem cell-like proliferating myeloid cells within inflamed tissues that could serve as a reservoir for tissue macrophages to adopt different activation states depending on the microenvironment. By linea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b666ba0a49024372456f3e1f97f5944c
https://europepmc.org/articles/PMC10002671/
https://europepmc.org/articles/PMC10002671/
Autor:
Erin E. Zwack, Ze Chen, Joseph C. Devlin, Zhi Li, Xuhui Zheng, Ada Weinstock, Keenan A. Lacey, Edward A. Fisher, David Fenyö, Kelly V. Ruggles, P’ng Loke, Victor J. Torres
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Staphylococcus aureusis an opportunistic pathogen and chief among bloodstream-infecting bacteria.S. aureusproduces an array of human-specific virulence factors that may contribute to immune suppression. Here, we defined the response of primary human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb10e9ea359010c238bd0203352912f3
https://doi.org/10.1073/pnas.2123017119
https://doi.org/10.1073/pnas.2123017119
Autor:
Peter T. Buckley, Rita Chan, Jeffrey Fernandez, Jinquan Luo, Keenan A. Lacey, Ashley L. DuMont, Aidan O’Malley, Randall J. Brezski, Songmao Zheng, Thomas Malia, Brian Whitaker, Adam Zwolak, Angela Payne, Desmond Clark, Martin Sigg, Eilyn R. Lacy, Anna Kornilova, Debra Kwok, Steve McCarthy, Bingyuan Wu, Brian Morrow, Jennifer Nemeth-Seay, Ted Petley, Sam Wu, William R. Strohl, Anthony Simon Lynch, Victor J. Torres
Publikováno v:
Cell Host & Microbe. 31:751-765.e11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4756f7a8083a9d7782669668c12b6439
https://doi.org/10.1016/j.chom.2023.04.004
https://doi.org/10.1016/j.chom.2023.04.004
Autor:
Victor J. Torres, Christopher J. Day, Ashira Lubkin, Michael P. Jennings, Keenan A. Lacey, Marilyn T. Vasquez, Tamara Reyes-Robles
Publikováno v:
Journal of Biological Chemistry. 295:17241-17250
Leukocidin ED (LukED) is a pore-forming toxin produced by Staphylococcus aureus, which lyses host cells and promotes virulence of the bacteria. LukED enables S. aureus to acquire iron by lysing erythrocytes, which depends on targeting the host recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bcb68e24eda5c6c5502326b3433deb
https://doi.org/10.1074/jbc.ra120.015757
https://doi.org/10.1074/jbc.ra120.015757
Autor:
Victor J. Torres, Christian Goosmann, Keenan A. Lacey, Gerben Marsman, Jessica R. Chapman, Beatrix Ueberheide, Xuhui Zheng
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Staphylococcus aureus bi-component pore-forming leukocidins are secreted toxins that directly target and lyse immune cells. Intriguingly, one of the leukocidins, Leukocidin AB (LukAB), is found associated with the bacterial cell envelope in addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cbdbd8390b4912c51e85bc50b75e4d
https://doi.org/10.1038/s41467-021-26517-z
https://doi.org/10.1038/s41467-021-26517-z