Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Keenan A Lacey"'
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007713 (2019)
Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. The cell wall-anchored prote
Externí odkaz:
https://doaj.org/article/10c1944b0bb743adbd57c8f6ef6f6f06
Autor:
Gerben Marsman, Xuhui Zheng, Dora Čerina, Keenan A. Lacey, Menghan Liu, Daniel Humme, Christian Goosmann, Volker Brinkmann, C.J. Harbort, Victor J. Torres, Arturo Zychlinsky
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114969- (2024)
Summary: The antimicrobial activity of histones was discovered in the 1940s, but their mechanism of action is not fully known. Here we show that methicillin-resistant Staphylococcus aureus (MRSA) is susceptible to histone H1 (H1), even in the presenc
Externí odkaz:
https://doaj.org/article/86c45c882cd04eb8844355c93b53224d
Autor:
Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005226 (2015)
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using a murine model of recurrent
Externí odkaz:
https://doaj.org/article/6832261a8fdf4af4abe77367d6c1163a
Autor:
Amelia St. John, Andrew I. Perault, Sabrina I. Giacometti, Alexis G. Sommerfield, Ashley L. DuMont, Keenan A. Lacey, Xuhui Zheng, Julia Sproch, Chris Petzold, Kristen Dancel-Manning, Sandra Gonzalez, Medini Annavajhala, Colleen Beckford, Nathalie Zeitouni, Feng-Xia Liang, Harm van Bakel, Bo Shopsin, Anne-Catrin Uhlemann, Alejandro Pironti, Victor J. Torres
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Nosocomial infections caused by multidrug-resistant (MDR) Enterobacter cloacae complex (ECC) pathogens are on the rise. However, the virulence strategies employed by these pathogens remain elusive. Here, we study the interaction of ECC clini
Externí odkaz:
https://doaj.org/article/d3aff886dd104f129b126519af1d6e50
Autor:
Keenan A. Lacey, Lee Serpas, Sohei Makita, Yueyang Wang, Ali Rashidfarrokhi, Chetna Soni, Sandra Gonzalez, Andre Moreira, Victor J. Torres, Boris Reizis
Publikováno v:
Journal of Experimental Medicine. 220
Extracellular DNase DNASE1L3 maintains tolerance to self-DNA in humans and mice, whereas the role of its homolog DNASE1 remains controversial, and the overall function of secreted DNases in immunity is unclear. We report that deletion of murine DNASE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e632011ce13eb175dfcd18b7210b57
https://doi.org/10.1084/jem.20221086
https://doi.org/10.1084/jem.20221086
Autor:
Denis G. Loredan, Joseph C. Devlin, Keenan A. Lacey, Nina Howard, Ze Chen, Erin E. Zwack, Jian-Da Lin, Kelly V. Ruggles, Kamal M. Khanna, Victor J. Torres, P’ng Loke
Publikováno v:
bioRxiv
Our previous studies identified a population of stem cell-like proliferating myeloid cells within inflamed tissues that could serve as a reservoir for tissue macrophages to adopt different activation states depending on the microenvironment. By linea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b666ba0a49024372456f3e1f97f5944c
https://europepmc.org/articles/PMC10002671/
https://europepmc.org/articles/PMC10002671/
Autor:
Erin E. Zwack, Ze Chen, Joseph C. Devlin, Zhi Li, Xuhui Zheng, Ada Weinstock, Keenan A. Lacey, Edward A. Fisher, David Fenyö, Kelly V. Ruggles, P’ng Loke, Victor J. Torres
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Staphylococcus aureusis an opportunistic pathogen and chief among bloodstream-infecting bacteria.S. aureusproduces an array of human-specific virulence factors that may contribute to immune suppression. Here, we defined the response of primary human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb10e9ea359010c238bd0203352912f3
https://doi.org/10.1073/pnas.2123017119
https://doi.org/10.1073/pnas.2123017119
Autor:
Keenan A. Lacey, Sandra Gonzalez, Frank Yeung, Gregory Putzel, Magdalena Podkowik, Alejandro Pironti, Bo Shopsin, Ken Cadwell, Victor J. Torres
Publikováno v:
mBio. 13
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital-acquired pneumonia. To better manage patients with MRSA pneumonia, we require a greater understanding of the host-pathogen interactions during infection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eddf26de12f47fd5d032843b59b3f6b1
https://doi.org/10.1128/mbio.01240-22
https://doi.org/10.1128/mbio.01240-22
Autor:
Peter T. Buckley, Rita Chan, Jeffrey Fernandez, Jinquan Luo, Keenan A. Lacey, Ashley L. DuMont, Aidan O’Malley, Randall J. Brezski, Songmao Zheng, Thomas Malia, Brian Whitaker, Adam Zwolak, Angela Payne, Desmond Clark, Martin Sigg, Eilyn R. Lacy, Anna Kornilova, Debra Kwok, Steve McCarthy, Bingyuan Wu, Brian Morrow, Jennifer Nemeth-Seay, Ted Petley, Sam Wu, William R. Strohl, Anthony Simon Lynch, Victor J. Torres
Publikováno v:
Cell Host & Microbe. 31:751-765.e11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4756f7a8083a9d7782669668c12b6439
https://doi.org/10.1016/j.chom.2023.04.004
https://doi.org/10.1016/j.chom.2023.04.004
Autor:
Victor J. Torres, Christopher J. Day, Ashira Lubkin, Michael P. Jennings, Keenan A. Lacey, Marilyn T. Vasquez, Tamara Reyes-Robles
Publikováno v:
Journal of Biological Chemistry. 295:17241-17250
Leukocidin ED (LukED) is a pore-forming toxin produced by Staphylococcus aureus, which lyses host cells and promotes virulence of the bacteria. LukED enables S. aureus to acquire iron by lysing erythrocytes, which depends on targeting the host recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bcb68e24eda5c6c5502326b3433deb
https://doi.org/10.1074/jbc.ra120.015757
https://doi.org/10.1074/jbc.ra120.015757