Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Keeling Suzanne Elaine"'
Autor:
Daniele Andreotti, Nigel S. Watson, Meenu Sareen, Chuen Chan, Jan Josef Scicinski, Alun D McCarthy, Panayiotis Alexandrou Procopiou, Brian Dymock, B.C. Ross, Michael A. Snowden, Keeling Suzanne Elaine, Julie L. Hutson, Brian Cox, Peter J Sharratt
Publikováno v:
Journal of Medicinal Chemistry. 39:207-216
Squalestatins without either the hydroxy group at C-4 or the carboxylic acid at C-3 or C-4 were prepared and evaluated for their ability to inhibit rat liver microsomal squalene synthase (SQS) in vitro. These modifications were well tolerated for com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a401dd488a7564884a3acf803da730cf
https://doi.org/10.1021/jm9504969
https://doi.org/10.1021/jm9504969
Autor:
B. E. Kirk, Nigel S. Watson, Anton R. P. Srikantha, Julie L. Hutson, Brian Cox, Keeling Suzanne Elaine
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1931-1936
A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf22bcd2a21a45efc943f712abee7f42
https://doi.org/10.1016/s0960-894x(01)80537-0
https://doi.org/10.1016/s0960-894x(01)80537-0
The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety
Autor:
Nigel S. Watson, B. E. Kirk, Ian P. Steeples, Richard Bell, Chuen Chan, Julia Widdowson, Julie L. Hutson, Brian Cox, Keeling Suzanne Elaine, Panayiotis A. Procopiou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2541-2546
In squalestatins possessing at C6 either a 4,6-dimethyloctenoate ester or a hydroxyl group, the 5-carboxylic acid is crucial for squalene synthase inhibitory activity. In the former seires, free carboxylic acids are not required at C3 or C4 for poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c058c108ed056a6d29b4d7f2b010c83a
https://doi.org/10.1016/s0960-894x(01)80713-7
https://doi.org/10.1016/s0960-894x(01)80713-7
Autor:
Julie L. Hutson, D. F. Hayman, Chuen Chan, R. B. Lamont, P. S. Jones, B. E. Kirk, E. J. Bailey, Hartley Cd, Keeling Suzanne Elaine, Graham G. A. Inglis
Publikováno v:
Journal of Medicinal Chemistry. 36:3646-3657
3,5-Dihydroxy-7-(N-imidazolyl)heptanoates 4 and the corresponding heptenoates 5 were synthesized as novel classed of potent HMG-CoA reductase (HMGR) inhibitors in which members of the latter series possess enzyme inhibitory activity greater than that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a44e7ac6d24e7941f26449ad1d11577
https://doi.org/10.1021/jm00075a020
https://doi.org/10.1021/jm00075a020
Autor:
Richard Bell, B. E. Kirk, Chuen Chan, Keeling Suzanne Elaine, Julia Widdowson, Julie L. Hutson, Brian Cox, Nigel S. Watson, Panayiotis Alexandrou Procopiou, I. P. Stepples
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f265b28de5f09eb05020300454ef4b8
https://doi.org/10.1002/chin.199427282
https://doi.org/10.1002/chin.199427282
Autor:
Keeling Suzanne Elaine, J. M. Pritchard, Julie L. Hutson, D. F. Hayman, Chuen Chan, Barry Clive Ross, Ian P. Steeples, B. E. Kirk, P. S. Jones, Nigel S. Watson, Graham George Adam Inglis, E. J. Bailey, Michael George Lester, Jan Josef Scicinski, C. D. Hartley, R. B. Lamont, G. Smith, Stephen J. Spooner
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0acb09b902e86942c0836e700ed5de83
https://doi.org/10.1002/chin.199413171
https://doi.org/10.1002/chin.199413171