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Akademický článek

IL-13–programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function

Autor: Maya E. Kotas, Camille M. Moore, Jose G. Gurrola II, Steven D. Pletcher, Andrew N. Goldberg, Raquel Alvarez, Sheyla Yamato, Preston E. Bratcher, Ciaran A. Shaughnessy, Pamela L. Zeitlin, Irene H. Zhang, Yingchun Li, Michael T. Montgomery, Keehoon Lee, Emily K. Cope, Richard M. Locksley, Max A. Seibold, Erin D. Gordon

Publikováno v: JCI Insight, Vol 7, Iss 13 (2022)

Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory an

Externí odkaz: https://doaj.org/article/6f5341174d7842269c992904cbd03de8

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Akademický článek

Co-infection of Malassezia sympodialis With Bacterial Pathobionts Pseudomonas aeruginosa or Staphylococcus aureus Leads to Distinct Sinonasal Inflammatory Responses in a Murine Acute Sinusitis Model

Autor: Keehoon Lee, Irene Zhang, Shari Kyman, Oliver Kask, Emily Kathryn Cope

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Host-associated bacteria and fungi, comprising the microbiota, are critical to host health. In the airways, the composition and diversity of the mucosal microbiota of patients are associated with airway health status. However, the relationship betwee

Externí odkaz: https://doaj.org/article/22171d5ce75e4a42b5dac063826b1e54

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Akademický článek

A single gene of a commensal microbe affects host susceptibility to enteric infection

Autor: Mi Young Yoon, Kyung Bae Min, Kang-Mu Lee, Yujin Yoon, Yaeseul Kim, Young Taek Oh, Keehoon Lee, Jongsik Chun, Byung-Yong Kim, Seok-Hwan Yoon, Insuk Lee, Chan Yeong Kim, Sang Sun Yoon

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

The interactions between gut bacteria and enteric pathogens are poorly understood. Here, Yoon et al. show that subinhibitory antibiotic treatment in a mouse model leads to overgrowth of an E. coli strain carrying a catalase-encoding gene that enhance

Externí odkaz: https://doaj.org/article/88f0e49f3bee4648a63f390e0eec4a60

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Akademický článek

Do the Bugs in Your Gut Eat Your Memories? Relationship between Gut Microbiota and Alzheimer’s Disease

Autor: Emily M. Borsom, Keehoon Lee, Emily K. Cope

Publikováno v: Brain Sciences, Vol 10, Iss 11, p 814 (2020)

The human microbiota is composed of trillions of microbial cells inhabiting the oral cavity, skin, gastrointestinal (GI) tract, airways, and reproductive organs. The gut microbiota is composed of dynamic communities of microorganisms that communicate

Externí odkaz: https://doaj.org/article/53b04ec2008548b08f00d112e95e9280

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Akademický článek

Heterogeneity of Microbiota Dysbiosis in Chronic Rhinosinusitis: Potential Clinical Implications and Microbial Community Mechanisms Contributing to Sinonasal Inflammation

Autor: Keehoon Lee, Steven D. Pletcher, Susan V. Lynch, Andrew N. Goldberg, Emily K. Cope

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Recent studies leveraging next-generation sequencing and functional approaches to understand the human microbiota have demonstrated the presence of diverse, niche-specific microbial communities at nearly every mucosal surface. These microbes contribu

Externí odkaz: https://doaj.org/article/e509b2b5d22042e0b891294bea3cabea

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Akademický článek

Differential immune responses to Segniliparus rotundus and Segniliparus rugosus infection and analysis of their comparative virulence profiles.

Autor: Jong-Seok Kim, Woo Sik Kim, Keehoon Lee, Choul-Jae Won, Jin Man Kim, Seok-Yong Eum, Won-Jung Koh, Sung Jae Shin

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59646 (2013)

Two closely related bacterial species, Segniliparus rotundus and Segniliparus rugosus, have emerged as important human pathogens, but little is known about the immune responses they elicit or their comparative pathophysiologies. To determine the viru

Externí odkaz: https://doaj.org/article/1fcb40f4c68447f3833ab83a020ae5f1

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Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer’s Disease Pathologies

Autor: Emily M. Borsom, Kathryn Conn, Christopher R. Keefe, Chloe Herman, Gabrielle M. Orsini, Allyson H. Hirsch, Melanie Palma Avila, George Testo, Sierra A. Jaramillo, Evan Bolyen, Keehoon Lee, J. Gregory Caporaso, Emily Cope

Publikováno v: Microbiology Spectrum. 11

The gut microbiota-brain axis is suspected to contribute to the development of Alzheimer’s Disease (AD), a neurodegenerative disease characterized by amyloid-β plaque deposition, neurofibrillary tangles, and neuroinflammation. To evaluate the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb854d2929bc10277a5a3b69a1265c2e
https://doi.org/10.1128/spectrum.03458-22

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Chemical Inhibitors of DksA1, a Conserved Bacterial Transcriptional Regulator, Suppressed Quorum Sensing-Mediated Virulence in Pseudomonas aeruginosa

Autor: Keehoon Lee, Wontae Hwang, Kyung Bae Min, Sang Sun Yoon

Pseudomonas aeruginosa is a Gram-negative bacterium of clinical importance. As an opportunistic pathogen, its virulence is dependent on quorum sensing (QS). Stringent response (SR), a conserved mechanism in the bacterial kingdom, is activated under d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b621ee828f09ac5c46ebf96dd2f9b55
https://doi.org/10.1101/2020.12.10.420422

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