A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions.

Autor: Rogers MT; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA.; Raytheon BBN Technologies, Synthetic Biology, 10 Moulton St, Cambridge, MA, 02138, USA., Gard AL; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Gaibler R; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Mulhern TJ; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Strelnikov R; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA.; Microsoft Corporation, 1 Memorial Drive, Cambridge, MA, 02142, USA., Azizgolshani H; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Cain BP; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Isenberg BC; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Haroutunian NJ; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Raustad NE; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA.; Department of Biology, Northeastern University, 360 Huntington Ave, Boston, MA, 02115, USA., Keegan PM; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA.; Department of Biomedical Engineering, University of Wisconsin Madison, 1550 Engineering Dr, Madison, WI, 53706, USA., Lech MP; Pfizer, Inc., 1 Portland St, Cambridge, MA, 02139, USA., Tomlinson L; Pfizer, Inc., 1 Portland St, Cambridge, MA, 02139, USA., Borenstein JT; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA., Charest JL; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA. jcharest@draper.com., Williams C; The Charles Stark Draper Laboratory Inc., 555 Technology Square, Cambridge, MA, 02139, USA. cwilliams@draper.com.

Publikováno v: Scientific reports [Sci Rep] 2021 Jun 09; Vol. 11 (1), pp. 12225. Date of Electronic Publication: 2021 Jun 09.

Sickle Cell Anemia Mediates Carotid Artery Expansive Remodeling That Can Be Prevented by Inhibition of JNK (c-Jun N-Terminal Kinase).

Autor: Song H; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Keegan PM; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Anbazhakan S; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Rivera CP; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.).; Department of Mechanics and Engineering Science at Peking University, Beijing, China (C.P.R., Y.F., Y.H., W.T.)., Feng Y; Department of Mechanics and Engineering Science at Peking University, Beijing, China (C.P.R., Y.F., Y.H., W.T.)., Omojola VO; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Clark AA; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Cai S; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Selma J; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.)., Gleason RL Jr; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.).; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta (R.L.G., E.A.B., M.O.P.)., Botchwey EA; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.).; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta (R.L.G., E.A.B., M.O.P.)., Huo Y; Department of Mechanics and Engineering Science at Peking University, Beijing, China (C.P.R., Y.F., Y.H., W.T.)., Tan W; Department of Mechanics and Engineering Science at Peking University, Beijing, China (C.P.R., Y.F., Y.H., W.T.)., Platt MO; From the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta (H.S., P.M.K., S.A., C.P.R., V.O.O., A.A.C., S.C., J.S., R.L.G., E.A.B., M.O.P.).; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta (R.L.G., E.A.B., M.O.P.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 May; Vol. 40 (5), pp. 1220-1230. Date of Electronic Publication: 2020 Mar 12.

Low-Cost Method to Monitor Patient Adherence to HIV Antiretroviral Therapy Using Multiplex Cathepsin Zymography.

Autor: Platt MO; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, IBB 1308, Atlanta, GA, 30332, USA. manu.platt@bme.gatech.edu.; The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. manu.platt@bme.gatech.edu., Evans D; Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa., Keegan PM; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, IBB 1308, Atlanta, GA, 30332, USA.; The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA., McNamara L; Clinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa., Parker IK; The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The George W. Woodruff School of Mechanical Engineering, Atlanta, GA, USA., Roberts LM; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, IBB 1308, Atlanta, GA, 30332, USA.; The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA., Caulk AW; The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The George W. Woodruff School of Mechanical Engineering, Atlanta, GA, USA., Gleason RL Jr; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Drive, IBB 1308, Atlanta, GA, 30332, USA.; The Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.; The George W. Woodruff School of Mechanical Engineering, Atlanta, GA, USA., Seifu D; Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia., Amogne W; Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Penny C; Oncology Division, Department of Internal Medicine, University of the Witwatersrand, Johannesburg, South Africa.

Publikováno v: Molecular biotechnology [Mol Biotechnol] 2016 Jan; Vol. 58 (1), pp. 56-64.

Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.

Autor: Awojoodu AO; Department of Biomedical Engineering and., Keegan PM; Department of Biomedical Engineering and., Lane AR; Department of Biology, Georgia Institute of Technology, Atlanta, GA; and., Zhang Y; Department of Biomedical Engineering and., Lynch KR; Department of Pharmacology, The University of Virginia, Charlottesville, VA., Platt MO; Department of Biomedical Engineering and., Botchwey EA; Department of Biomedical Engineering and.

Publikováno v: Blood [Blood] 2014 Sep 18; Vol. 124 (12), pp. 1941-50. Date of Electronic Publication: 2014 Jul 29.

Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells.

Autor: Keegan PM; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA., Surapaneni S, Platt MO

Publikováno v: Anemia [Anemia] 2012; Vol. 2012, pp. 201781. Date of Electronic Publication: 2012 Apr 09.