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pro vyhledávání: '"Keegan Fitzpatrick"'
Autor:
Christopher S. Callam, Craig A. McElroy, Stephanie Fabry, Justin Smith, Christopher M. Hadad, Jojo Joseph, Andrew J. Franjesevic, Qinggeng Zhuang, Nathan Yoshino, Thomas Corrigan, Ashley DeYong, Sydney B. Sillart, Ryan J. Yoder, Rachel D. Dicken, William H. Coldren, Keegan Fitzpatrick, Özlem Doğan Ekici, Travis G. Blanton
Publikováno v:
Journal of Medicinal Chemistry. 61:7034-7042
After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. When aged, known reactivators of OP-inhibited AChE are no longer effective