Zobrazeno 1 - 10 of 44 pro vyhledávání: '"Keefe T Chan"'
1
Akademický článek
Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation
Autor: Haoran Zhu, Keefe T Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S Trigos, Dovile Anderson, Darren J Creek, David P De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B Pearson, Jian Kang
Publikováno v: eLife, Vol 11 (2022)
Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that must be overcome during transformation. We previously demonstrated that AKT-induc
Externí odkaz: https://doaj.org/article/1a069ee3d19e47d0b3a564db5b2cdc6d
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2
Akademický článek
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Autor: Jian Kang, Natalie Brajanovski, Keefe T. Chan, Jiachen Xuan, Richard B. Pearson, Elaine Sanij
Publikováno v: Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-22 (2021)
Abstract Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Externí odkaz: https://doaj.org/article/977bdd4f781a4596b021f41e01e07138
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3
Akademický článek
CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer
Autor: Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and ove
Externí odkaz: https://doaj.org/article/e147f3013f3440d1be5ac0b31368773d
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