Výsledky vyhledávání - "Kee-Chung Han"

Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer

Autor: Jun O. Liu, Hyo-eun C. Bhang, Yoshiyuki Matsui, Kee Chung Han, Benjamin A. Nacev, Jing Xu, Joong Sup Shim, Martin G. Pomper, Alan So, Curtis R. Chong, Surajit Dhara, Shridhar Bhat

Publikováno v: JNCI: Journal of the National Cancer Institute. 102:1855-1873

Angiogenesis plays an important role in tumor growth and metastasis; therefore, inhibition of angiogenesis is a promising strategy for developing new anticancer drugs. Type 2 methionine aminopeptidase (MetAP2) protein is likely a molecular target of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64f2ef32d55451a605cfbce18149856
https://doi.org/10.1093/jnci/djq457

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Kinetic and Mutational Studies of the Number of Interacting Divalent Cations Required by Bacterial and Human Methionine Aminopeptidases

Autor: Xiaoyi V. Hu, Albert S. Mildvan, Kee Chung Han, Jun O. Liu, Xiaochun Chen

Publikováno v: Biochemistry. 46:12833-12843

Methionine aminopeptidases (MetAP) are responsible for the proteolytic removal of the initiator methionine from nascent proteins. This processing permits multiple posttranslational modifications and protein turnover. We have cloned, expressed in Esch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b6511835143c97982a31453648108e
https://doi.org/10.1021/bi701127x

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Branched Diacylglycerol-Lactones as Potent Protein Kinase C Ligands and α-Secretase Activators

Autor: Kee Chung Han, Yerim Kim, Su-Yeon Kim, Inhee Mook-Jung, Jeewoo Lee, Jee Hye Lo Han, H.-N. Kim, Ha Hee Jin, Daniel J. Lundberg, Ji-Hye Kang, Victor E. Marquez, Peter M. Blumberg, Nancy E. Lewin, Young Ho Kim, Hae Suk Youn, Larry V. Pearce

Publikováno v: Journal of Medicinal Chemistry. 49:2028-2036

Using as our lead structure a potent PKC ligand (1) that we had previously described, we investigated a series of branched DAG-lactones to optimize the scaffold for PKC binding affinity and reduced lipophilicity, and we examined the potential utility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c039d85ea9dede9f1c2125ee4b6c72c
https://doi.org/10.1021/jm0509391

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Conformationally Constrained Analogues of Diacylglycerol. 18. The Incorporation of a Hydroxamate Moiety into Diacylglycerol-Lactones Reduces Lipophilicity and Helps Discriminate between sn-1 and sn-2 Binding Modes to Protein Kinase C (PK-C). Implications for Isozyme Specificity

Autor: Larry L. Pearce, Kee-Chung Han, Jeewoo Lee, Shunqi Yan, Ji-Hye Kang, Marc C. Nicklaus, Samira Benzaria, Peter M. Blumberg, Victor E. Marquez, Nancy E. Lewin

Publikováno v: Journal of Medicinal Chemistry. 44:4309-4312

An approach to reduce the log P in a series of diacylglycerol (DAG)-lactones known for their high binding affinity for protein kinase C (PK-C) is presented. Branched alkyl groups with reduced lipophilicity were selected and combined with the replacem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c34c73704c34175097cc81f511e6d6
https://doi.org/10.1021/jm0103965

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ChemInform Abstract: 5-Acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a Novel Template for Protein Kinase C (PKC) Binding

Autor: Su-Yeon Kim, Jeewoo Lee, Peter M. Blumberg, Sang-Yoon Lee, Victor E. Marquez, Nancy E. Lewin, Ji-Hye Kang, Lionel S. Best, Kee-Chung Han

Publikováno v: ChemInform. 32

A series of alkyl tetrahydrofuran-2-carboxylates (1–4) bearing a new set of three pharmacophoric groups were tested as protein kinase C (PKC) ligands. The compounds were synthesized from commercially available glycidyl 4-methoxyphenyl ether. The co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db6cc59b4025549e8be5060844744bdc
https://doi.org/10.1002/chin.200132112

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Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha

Autor: Jeewoo Lee, María Laura García-Bermejo, Kee-Chung Han, Peter M. Blumberg, Toshio Kuroki, Victor E. Marquez, Qiming Wang, Motoi Ohba, Federico Coluccio Leskow, Teruhiko Fujii, Marcelo G. Kazanietz

Publikováno v: The Journal of biological chemistry. 277(1)

Phorbol esters, the archetypical (PKC) activators, induce apoptosis in androgen-sensitive LNCaP prostate cancer cells. In this study we evaluate the effect of a novel class of PKC ligands, the diacylglycerol (DAG)-lactones, as inducers of apoptosis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7106a37a140137a9871c752095b5c269
https://pubmed.ncbi.nlm.nih.gov/11584014

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5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding

Autor: Su-Yeon Kim, Victor E. Marquez, Jeewoo Lee, Lionel S. Best, Peter M. Blumberg, Kee-Chung Han, Sang-Yoon Lee, Ji-Hye Kang, Nancy E. Lewin

Publikováno v: Farmaco (Societa chimica italiana : 1989). 56(3)

A series of alkyl tetrahydrofuran-2-carboxylates (1-4) bearing a new set of three pharmacophoric groups were tested as protein kinase C (PKC) ligands. The compounds were synthesized from commercially available glycidyl 4-methoxyphenyl ether. The corr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23f0bac963a129ede476fd652ebbd68
https://pubmed.ncbi.nlm.nih.gov/11409328

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Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?

Autor: Nancy E. Lewin, Samira Benzaria, Jeewoo Lee, Victor E. Marquez, Dipak K. Bhattacharyya, Kassoum Nacro, Peter M. Blumberg, Ji-Hye Kang, Kee-Chung Han, Bruno Bienfait

Publikováno v: Journal of medicinal chemistry. 43(5)

The design of potent protein kinase C (PK-C) ligands with low nanomolar binding affinities was accomplished by the combined use of pharmacophore- and receptor-guided approaches based on the structure of the physiological enzyme activator, diacylglyce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fd64cb05a5615ab7971428431b3a59
https://pubmed.ncbi.nlm.nih.gov/10715158

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Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores

Autor: Victor E. Marquez, Peter M. Blumberg, Jeewoo Lee, Christina M. Torres, Dipak K. Bhattacharyya, Sang-Yoon Lee, Ji-Hye Kang, Kee-Chung Han

Publikováno v: Journal of medicinal chemistry. 42(20)

A series of substituted tetrahydrofurans with an embedded glycerol backbone carrying additional tetrahydrofuranylideneacetate or tetrahydrofuranylacetate motifs were grouped into four distinct templates (I-IV) according to stereochemistry. The compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf75fbd4da285089bc44b388b6820d1
https://pubmed.ncbi.nlm.nih.gov/10514283

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