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Akademický článek

Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR

Autor: Seongjae Kim, Jung Min Park, Soeun Park, Eunsun Jung, Dongmi Ko, Minsu Park, Juyeon Seo, Kee Dal Nam, Yong Koo Kang, Kyoungmin Lee, Lee Farrand, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)

Abstract Background Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis. Simultaneous overexpression of c-MET and EGFR in TNBC is associated with worse clinicopathological fea

Externí odkaz: https://doaj.org/article/a78d66b75c4a4c13ba43af1a16e5d520

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Akademický článek

β-Escin overcomes trastuzumab resistance in HER2-positive breast cancer by targeting cancer stem-like features

Autor: Soeun Park, Jung Min Park, Minsu Park, Dongmi Ko, Seongjae Kim, Juyeon Seo, Kee Dal Nam, Eunsun Jung, Lee Farrand, Yoon-Jae Kim, Ji Young Kim, Jae Hong Seo

Publikováno v: Cancer Cell International, Vol 22, Iss 1, Pp 1-16 (2022)

Abstract Background The emergence of de novo or intrinsic trastuzumab resistance is exceedingly high in breast cancer that is HER2 positive and correlates with an abundant cancer stem cell (CSC)-like population. We sought to examine the capacity of �

Externí odkaz: https://doaj.org/article/c8b545e47a8e4566be62c3c7b3c3ac21

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Akademický článek

The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells

Autor: Soeun Park, Yoon-Jae Kim, Jung Min Park, Minsu Park, Kee Dal Nam, Lee Farrand, Cong-Truong Nguyen, Minh Thanh La, Jihyae Ann, Jeewoo Lee, Ji Young Kim, Jae Hong Seo

Publikováno v: Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)

Abstract N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill

Externí odkaz: https://doaj.org/article/5abd2556d6fa4f7bb936d8f0108b8169

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Akademický článek

(E)-N-(3,3-Diphenylallylidene)naphthalen-1-amine

Autor: Jae Kyun Lee, Kee Dal Nam, Joo Hwan Cha, Yong Seo Cho, Joon Kyun Lee

Publikováno v: Acta Crystallographica Section E, Vol 69, Iss 7, Pp o1025-o1025 (2013)

The title compound, C25H19N, adopts an E conformation about the C=N bond. The naphthalene ring system and the phenyl rings form dihedral angles 38.1 (1), 46.9 (8) and 48.5 (1)°, respectively, with the mean plane of the central enimino fragment. The

Externí odkaz: https://doaj.org/article/a42ce3c9c1494af5917576390b1a4f67

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Akademický článek

(E)-N-[(E)-3-(4-Nitrophenyl)allylidene]naphthalen-1-amine

Autor: Kee Dal Nam, Joo Hwan Cha, Yong Seo Cho, Jae Kyun Lee, Ae Nim Pae

Publikováno v: Acta Crystallographica Section E, Vol 69, Iss 4, Pp o548-o548 (2013)

In the title compound, C19H14N2O2, the dihedral angle between the mean planes of the 4-nitrophenyl ring and the naphthalene ring system is 12.79 (2)°. The imine group displays a C—C—N=C torsion angle of 41.0 (2)° and the C=N group has an E conf

Externí odkaz: https://doaj.org/article/f17fb7ed9ecc440fb2d2dbe7cc96acae

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