Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kee Chuan Goh"'
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 2.9MB, In-vitro kinase assay, Histology, Cell proliferation, MANOVA analysis for genomic correlates of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ecb3048e6ff5affcb194a51978b5d1
https://doi.org/10.1158/1535-7163.22497421
https://doi.org/10.1158/1535-7163.22497421
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389efae3908c20bd53e37aa050195e71
https://doi.org/10.1158/1535-7163.c.6535609
https://doi.org/10.1158/1535-7163.c.6535609
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 663K, Ambit kinome tree, Cell proliferation data, Pharmacokinetics, Body weight changes in PC3 efficacy study, Active vessel stain in COLO-205 efficacy study, MV4-11 efficacy model, Drug sensitivity profiling and correlation to mutation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407e7e397fec9712aed4f01696117bc4
https://doi.org/10.1158/1535-7163.22497424
https://doi.org/10.1158/1535-7163.22497424
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
XLS file - 167K, Table 1: Cell line drug sensitivity data for SB2343 and mutations in cancer genes. Table 2: Results from MANOVA analysis of cancer genes as modifiers of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794bb76ff68be2e6a52cec2e5c03efb5
https://doi.org/10.1158/1535-7163.22497418
https://doi.org/10.1158/1535-7163.22497418
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Figures and Materials and Metholds from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b51e86e9b7513857bdd252443925fa
https://doi.org/10.1158/1535-7163.22485351.v1
https://doi.org/10.1158/1535-7163.22485351.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 2 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45515ad58f3fa654f42c307ee91c362b
https://doi.org/10.1158/1535-7163.22485345
https://doi.org/10.1158/1535-7163.22485345
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 1 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea26232b2120ba418d9671855d8e245c
https://doi.org/10.1158/1535-7163.22485348.v1
https://doi.org/10.1158/1535-7163.22485348.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Supplementary Table 3 from SB939, a Novel Potent and Orally Active Histone Deacetylase Inhibitor with High Tumor Exposure and Efficacy in Mouse Models of Colorectal Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab078191ad592debcca47d0ad3279d38
https://doi.org/10.1158/1535-7163.22485342.v1
https://doi.org/10.1158/1535-7163.22485342.v1
Autor:
Jeanette Marjorie Wood, Kantharaj Ethirajulu, Haishan Wang, Stefan Hart, Hannes Hentze, Kee Chuan Goh, Zahid Bonday, Yung Kiang Loh, Ai Leng Liang, Sven Pettersson, Gediminas Greicius, Pauline Yeo, Nina Sausgruber, Xiaofeng Wu, Chang Yong Hu, Kanda Sangthongpitag, Veronica Novotny-Diermayr
Although clinical responses in liquid tumors and certain lymphomas have been reported, the clinical efficacy of histone deacetylase inhibitors in solid tumors has been limited. This may be in part due to the poor pharmacokinetic of these drugs, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bfd470f6ae571ff56fa8b9560145061
https://doi.org/10.1158/1535-7163.c.6531900
https://doi.org/10.1158/1535-7163.c.6531900
Autor:
Robin D.G. Cooper, George W. Huffman, Jack E. Baldwin, Christopher J. Schofield, Kee-Chuan Goh, Mark E. Wood
The role of sulphur in cephalosporin biosynthesis was probed by evaluation of a carbocyclic analogue of deacetoxycephalosporin C as a substrate for DAOC/DAC synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ef43e7df7ae08556ea0d72291fa81d
https://doi.org/10.1016/s0960-894x(00)80269-3
https://doi.org/10.1016/s0960-894x(00)80269-3