A spatial human thymus cell atlas mapped to a continuous tissue axis.

Autor: Yayon N; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.; European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Kedlian VR; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Boehme L; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium., Suo C; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.; Department of Paediatrics, Cambridge University Hospitals, Cambridge, UK., Wachter BT; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA., Beuschel RT; Laboratory of Immune System Biology, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, National Institute of Allergy and Infectious Diseases (NIH), Bethesda, MD, USA., Amsalem O; Division of Endocrinology, Diabetes and Metabolism, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Polanski K; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Koplev S; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Tuck E; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Dann E; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Van Hulle J; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium., Perera S; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Putteman T; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium., Predeus AV; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Dabrowska M; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Richardson L; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Tudor C; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Kreins AY; Department of Immunology and Gene Therapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Infection, Immunity and Inflammation Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK., Engelbert J; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Stephenson E; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Kleshchevnikov V; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., De Rita F; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK., Crossland D; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK., Bosticardo M; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA., Pala F; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA., Prigmore E; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Chipampe NJ; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Prete M; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Fei L; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., To K; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Barker RA; Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., He X; Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Van Nieuwerburgh F; Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Bayraktar OA; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Patel M; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK., Davies EG; Department of Immunology and Gene Therapy, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Infection, Immunity and Inflammation Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK., Haniffa MA; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK.; Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Uhlmann V; European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, UK., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD, USA., Germain RN; Laboratory of Immune System Biology, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, National Institute of Allergy and Infectious Diseases (NIH), Bethesda, MD, USA. rgermain@niaid.nih.gov., Radtke AJ; Laboratory of Immune System Biology, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, National Institute of Allergy and Infectious Diseases (NIH), Bethesda, MD, USA. andrea.radtke@nih.gov., Marioni JC; European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, UK. marioni@ebi.ac.uk.; University of Cambridge, Cancer Research UK, Cambridge, UK. marioni@ebi.ac.uk., Taghon T; Department of Diagnostic Sciences, Ghent University, Ghent, Belgium. tom.taghon@ugent.be.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. tom.taghon@ugent.be., Teichmann SA; Cellular Genetics, Wellcome Sanger Institute, Cambridge, UK. sat1003@cam.ac.uk.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. sat1003@cam.ac.uk.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8039), pp. 708-718. Date of Electronic Publication: 2024 Nov 20.

A spatial human thymus cell atlas mapped to a continuous tissue axis.

Autor: Yayon N; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom.; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, United Kingdom., Kedlian VR; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Boehme L; Ghent University, Department of Diagnostic Sciences, Ghent, Belgium., Suo C; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Wachter B; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, Bethesda, MD, United States., Beuschel RT; National Institute of Allergy and Infectious Diseases, NIH, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Bethesda, MD, United States., Amsalem O; Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Endocrinology, Diabetes and Metabolism, Boston, MA, United States., Polanski K; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Koplev S; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Tuck E; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Dann E; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Van Hulle J; Ghent University, Department of Diagnostic Sciences, Ghent, Belgium., Perera S; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Putteman T; Ghent University, Department of Diagnostic Sciences, Ghent, Belgium., Predeus AV; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Dabrowska M; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Richardson L; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Tudor C; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Kreins AY; Great Ormond Street Hospital for Children NHS Foundation Trust, Department of Immunology and Gene Therapy, London, United Kingdom.; UCL Great Ormond Street Institute of Child Health, Infection, Immunity and Inflammation Research & Teaching Department, London, United Kingdom., Engelbert J; Newcastle University, Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne, United Kingdom., Stephenson E; Newcastle University, Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne, United Kingdom., Kleshchevnikov V; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., De Rita F; Freeman Hospital, Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Newcastle upon Tyne, United Kingdom., Crossland D; Freeman Hospital, Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Newcastle upon Tyne, United Kingdom., Bosticardo M; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, Bethesda, MD, United States., Pala F; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, Bethesda, MD, United States., Prigmore E; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Chipampe NJ; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Prete M; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Fei L; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., To K; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Barker RA; University of Cambridge, John van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom., He X; University of Cambridge, John van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom., Van Nieuwerburgh F; Ghent University, Laboratory of Pharmaceutical Biotechnology, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Bayraktar O; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Patel M; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom., Davies GE; Great Ormond Street Hospital for Children NHS Foundation Trust, Department of Immunology and Gene Therapy, London, United Kingdom.; UCL Great Ormond Street Institute of Child Health, Infection, Immunity and Inflammation Research & Teaching Department, London, United Kingdom., Haniffa MA; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom.; Newcastle University, Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne, United Kingdom., Uhlmann V; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, United Kingdom., Notarangelo LD; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, Bethesda, MD, United States., Germain RN; National Institute of Allergy and Infectious Diseases, NIH, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Bethesda, MD, United States., Radtke AJ; National Institute of Allergy and Infectious Diseases, NIH, Lymphocyte Biology Section and Center for Advanced Tissue Imaging, Bethesda, MD, United States., Marioni JC; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, United Kingdom.; University of Cambridge, Cancer Research UK, Cambridge, United Kingdom., Taghon T; Ghent University, Department of Diagnostic Sciences, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Teichmann SA; Wellcome Sanger Institute, Cellular Genetics, Cambridge, United Kingdom.; University of Cambridge, Cavendish Laboratory, Cambridge, United Kingdom.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 27. Date of Electronic Publication: 2023 Oct 27.

A cell atlas of human thymic development defines T cell repertoire formation.

Autor: Park JE; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Botting RA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Domínguez Conde C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Popescu DM; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Lavaert M; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium., Kunz DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.; Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK., Goh I; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Stephenson E; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Ragazzini R; Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK., Tuck E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Wilbrey-Clark A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Roberts K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Kedlian VR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK., He X; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK., Webb S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Maunder D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Vandamme N; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Mahbubani KT; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Crossland D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK., de Rita F; Department of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK., Fuller A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Filby A; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Reynolds G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Dixon D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Lisgo S; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Henderson D; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Vento-Tormo R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Bayraktar OA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Barker RA; John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.; WT-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus, Cambridge CB2 0AW, UK., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Saeys Y; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium., Bonfanti P; Epithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.; Institute of Immunity and Transplantation, University College London, London, UK., Behjati S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK., Clatworthy MR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Taghon T; Faculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium. m.a.haniffa@newcastle.ac.uk tom.taghon@ugent.be st9@sanger.ac.uk.; Cancer Research Institute Ghent (CRIG), Ghent University, Ghent, Belgium., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. m.a.haniffa@newcastle.ac.uk tom.taghon@ugent.be st9@sanger.ac.uk.; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. m.a.haniffa@newcastle.ac.uk tom.taghon@ugent.be st9@sanger.ac.uk.; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Feb 21; Vol. 367 (6480).

Autor: Gerasymenko IM, Kleschevnikov VV, Kedlian VR, Sakhno LO, Arbuzova IA, Sheludko YV, Dosenko VE, Kuchuk NV

Publikováno v: TSitologiia i genetika [Tsitol Genet] 2017 Jan-Feb; Vol. 51 (1), pp. 3-11.