Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kedar Nath Natarajan"'
Autor:
Maria Stahl Madsen, Marjoleine F. Broekema, Martin Rønn Madsen, Arjen Koppen, Anouska Borgman, Cathrin Gräwe, Elisabeth G. K. Thomsen, Denise Westland, Mariette E. G. Kranendonk, Marian Groot Koerkamp, Nicole Hamers, Alexandre M. J. J. Bonvin, José M. Ramos Pittol, Kedar Nath Natarajan, Sander Kersten, Frank C. P. Holstege, Houshang Monajemi, Saskia W. C. van Mil, Michiel Vermeulen, Birthe B. Kragelund, David Cassiman, Susanne Mandrup, Eric Kalkhoven
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Mutations in PPARγ lead to lipodystrophy, but the mechanisms by which the mutations affect the activity in chromatin is unknown. Here, Madsen, Broekema et al. showed that mutations affecting two intermolecular interactions compromise chromatin remod
Externí odkaz:
https://doaj.org/article/bb99d7ed4031494bb213b8c0686b2ffe
Autor:
Anna S. E. Cuomo, Daniel D. Seaton, Davis J. McCarthy, Iker Martinez, Marc Jan Bonder, Jose Garcia-Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew Knights, Kedar Nath Natarajan, HipSci Consortium, Ludovic Vallier, John C. Marioni, Mariya Chhatriwala, Oliver Stegle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Studying the genetic effects on early stages of human development is challenging due to a scarcity of biological material. Here, the authors utilise induced pluripotent stem cells from 125 donors to track gene expression changes and expression quanti
Externí odkaz:
https://doaj.org/article/a7b1f1030ed944ff83690e903da90113
Autor:
Kedar Nath Natarajan, Zhichao Miao, Miaomiao Jiang, Xiaoyun Huang, Hongpo Zhou, Jiarui Xie, Chunqing Wang, Shishang Qin, Zhikun Zhao, Liang Wu, Naibo Yang, Bo Li, Yong Hou, Shiping Liu, Sarah A. Teichmann
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Single-cell RNA-seq technologies require library preparation prior to sequencing. Here, we present the first report to compare the cheaper BGISEQ-500 platform to the Illumina HiSeq platform for scRNA-seq. We generate a resource of 468 single
Externí odkaz:
https://doaj.org/article/66b4691e7a7a49749d396ac0be8abd99
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
ATAC-seq is widely used to identify regulatory regions in the genome. Here the authors develop a simple and robust plate-based single-cell ATAC-seq method that works in fresh and cryopreserved cells.
Externí odkaz:
https://doaj.org/article/4f8114e572994fd2b334a80d5dbcfc5c
Autor:
Gozde Kar, Jong Kyoung Kim, Aleksandra A. Kolodziejczyk, Kedar Nath Natarajan, Elena Torlai Triglia, Borbala Mifsud, Sarah Elderkin, John C. Marioni, Ana Pombo, Sarah A. Teichmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have gre
Externí odkaz:
https://doaj.org/article/c747a0f3ef654e3ebe5c97e9ab3dfe7f
Autor:
Anna S. E. Cuomo, Daniel D. Seaton, Davis J. McCarthy, Iker Martinez, Marc Jan Bonder, Jose Garcia-Bernardo, Shradha Amatya, Pedro Madrigal, Abigail Isaacson, Florian Buettner, Andrew Knights, Kedar Nath Natarajan, HipSci Consortium, Ludovic Vallier, John C. Marioni, Mariya Chhatriwala, Oliver Stegle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/a8a149af37a3453ea2499263f7e30501
Autor:
Shreya Mishra, Neetesh Pandey, Smriti Chawla, Madhu Sharma, Omkar Chandra, Indra Prakash Jha, Debarka SenGupta, Kedar Nath Natarajan, Vibhor Kumar
Publikováno v:
Genome Research. 33:218-231
The true benefits of large single-cell transcriptome and epigenome data sets can be realized only with the development of new approaches and search tools for annotating individual cells. Matching a single-cell epigenome profile to a large pool of ref
Autor:
Esha Madan, António M. Palma, Vignesh Vudatha, Jose G. Trevino, Kedar Nath Natarajan, Robert A. Winn, Kyoung Jae Won, Trevor A. Graham, Ronny Drapkin, Stuart A.C. McDonald, Paul B. Fisher, Rajan Gogna
Publikováno v:
Cancer Res
The majority of human cancers evolve over time through the stepwise accumulation of somatic mutations followed by clonal selection akin to Darwinian evolution. However, the in-depth mechanisms that govern clonal dynamics and selection remain elusive,
Autor:
Julie Lee, Andreas Fønss Møller, Shinhyeok Chae, Alexandra Bussek, Tae Joo Park, Youni Kim, Hyun-Shik Lee, Tune H. Pers, Taejoon Kwon, Jakub Sedzinski, Kedar Nath Natarajan
Publikováno v:
Lee, J, Møller, A F, Chae, S, Bussek, A, Park, T J, Kim, Y, Lee, H S, Pers, T H, Kwon, T, Sedzinski, J & Natarajan, K N 2023, ' A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of development ', Science Advances, vol. 9, no. 14, eadd5745 . https://doi.org/10.1126/sciadv.add5745
Lee, J, Møller, A F, Chae, S, Bussek, A, Park, T J, Kim, Y, Lee, H S, Pers, T H, Kwon, T, Sedzinski, J & Natarajan, K N 2023, ' A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of development ', Science Advances, vol. 9, no. 14, pp. eadd5745 . https://doi.org/10.1126/sciadv.add5745
Lee, J, Møller, A F, Chae, S, Bussek, A, Park, T J, Kim, Y, Lee, H S, Pers, T H, Kwon, T, Sedzinski, J & Natarajan, K N 2023, ' A single-cell, time-resolved profiling of Xenopus mucociliary epithelium reveals nonhierarchical model of development ', Science Advances, vol. 9, no. 14, pp. eadd5745 . https://doi.org/10.1126/sciadv.add5745
The specialized cell-types of the mucociliary epithelium (MCE) lining the respiratory tract enable continuous airway clearing, with its defects leading to chronic respiratory diseases. The molecular mechanisms driving cell-fate acquisition and tempor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6540531ea55674161321da439ecb10f2
https://orbit.dtu.dk/en/publications/0ab07f21-991f-4c0e-a665-73c2bb3b7699
https://orbit.dtu.dk/en/publications/0ab07f21-991f-4c0e-a665-73c2bb3b7699
Autor:
Rahul Agrawal, Kedar Nath Natarajan
Publikováno v:
Advances in Cancer Research ISBN: 9780443133541
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd1013356ee84d2e45e7630bd3fb275
https://doi.org/10.1016/bs.acr.2023.02.006
https://doi.org/10.1016/bs.acr.2023.02.006