Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.

Autor: Pigoni M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Uzquiano A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Paulsen B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kedaigle AJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yang SM; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Symvoulidis P; McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA., Adiconis X; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Velasco S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sartore R; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kim K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tucewicz A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tropp SY; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Tsafou K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jin X; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Society of Fellows, Harvard University, Cambridge, MA 02138, USA., Barrett L; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chen F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Boyden ES; McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; MIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Harvard-MIT Health Sciences & Technology Program (HST), Harvard Medical School, Boston, MA 02115, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA 02138, USA.; Department of Brain of Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Department of Media Arts and Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Levin JZ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2023 Sep 05; Vol. 32 (18), pp. 2773-2786.

Autism genes converge on asynchronous development of shared neuron classes.

Autor: Paulsen B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Velasco S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. silvia.velasco@mcri.edu.au.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. silvia.velasco@mcri.edu.au.; Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia. silvia.velasco@mcri.edu.au., Kedaigle AJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pigoni M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Quadrato G; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Deo AJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Psychiatry, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA.; Rutgers University Behavioral Health Care, Piscataway, NJ, USA., Adiconis X; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Uzquiano A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sartore R; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang SM; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Simmons SK; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Symvoulidis P; MIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Kim K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsafou K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Podury A; MIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Harvard-MIT Health Sciences & Technology Program (HST), Harvard Medical School, Boston, MA, USA., Abbate C; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tucewicz A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Smith SN; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Albanese A; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Barrett L; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sanjana NE; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; New York Genome Center, New York, NY, USA.; Department of Biology, New York University, New York, NY, USA., Shi X; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chung K; Institute for Medical Engineering and Science, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Picower Institute for Learning and Memory, Departments of Chemical Engineering and Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; New York Genome Center, New York, NY, USA., Lage K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Surgery and Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Boyden ES; MIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Harvard-MIT Health Sciences & Technology Program (HST), Harvard Medical School, Boston, MA, USA.; McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA, USA.; Department of Brain of Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Department of Media Arts and Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Levin JZ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. paola_arlotta@harvard.edu.

Publikováno v: Nature [Nature] 2022 Feb; Vol. 602 (7896), pp. 268-273. Date of Electronic Publication: 2022 Feb 02.

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Autor: Bielecki P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. piotr.stanislaw.bielecki@gmail.com.; Celsius Therapeutics, Cambridge, MA, USA. piotr.stanislaw.bielecki@gmail.com., Riesenfeld SJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. sriesenfeld@uchicago.edu.; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. sriesenfeld@uchicago.edu.; Department of Medicine, University of Chicago, Chicago, IL, USA. sriesenfeld@uchicago.edu., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Torlai Triglia E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kowalczyk MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ricardo-Gonzalez RR; Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, Sandler Asthma Research Center, University of California San Francisco, San Francisco, CA, USA., Lian M; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Amezcua Vesely MC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Kroehling L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Xu H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Muus C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Ludwig LS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Christian E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tao L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kedaigle AJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Steach HR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., York AG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Skadow MH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yaghoubi P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jarret A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., McGee HM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Sciences, La Jolla, CA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Licona-Limón P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, Mexico., Bailis W; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jackson R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gagliani N; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital, Stockholm, Sweden., Gasteiger G; Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Locksley RM; Department of Medicine, Sandler Asthma Research Center, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aregev@broadinstitute.org.; Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aregev@broadinstitute.org.; Genentech, South San Francisco, CA, USA. aregev@broadinstitute.org., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. richard.flavell@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. richard.flavell@yale.edu.

Publikováno v: Nature [Nature] 2021 Apr; Vol. 592 (7852), pp. 128-132. Date of Electronic Publication: 2021 Feb 03.

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.

Autor: Ding J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Adiconis X; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Simmons SK; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kowalczyk MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hession CC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marjanovic ND; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hughes TK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Wadsworth MH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Burks T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kwon JYH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barak B; McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA., Ge W; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kedaigle AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Carroll S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Li S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Medical Engineering and Science, Department of Chemistry, MIT, Cambridge, MA, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA., Villani AC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute of Integrative Cancer Research, Cambridge, MA, USA.; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA, USA., Levin JZ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. jlevin@broadinstitute.org.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2020 Jun; Vol. 38 (6), pp. 737-746. Date of Electronic Publication: 2020 Apr 06.

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.

Autor: Velasco S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kedaigle AJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Simmons SK; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nash A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rocha M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Quadrato G; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC, Los Angeles, CA, USA., Paulsen B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Adiconis X; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Levin JZ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. paola_arlotta@harvard.edu.

Publikováno v: Nature [Nature] 2019 Jun; Vol. 570 (7762), pp. 523-527. Date of Electronic Publication: 2019 Jun 05.