Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kecia L, Feathers"'
Autor:
Maide Ö. Raeker, Nirosha D. Perera, Athanasios J. Karoukis, Lisheng Chen, Kecia L. Feathers, Robin R. Ali, Debra A. Thompson, Abigail T. Fahim
Publikováno v:
Cells, Vol 13, Iss 12, p 1068 (2024)
Choroideremia is an X-linked chorioretinal dystrophy caused by mutations in CHM, encoding Rab escort protein 1 (REP-1), leading to under-prenylation of Rab GTPases (Rabs). Despite ubiquitous expression of CHM, the phenotype is limited to degeneration
Externí odkaz:
https://doaj.org/article/46723e856b1640f98e5d3ac2dd01bda5
Autor:
Lisheng Chen, N. Dayanthi Perera, Athanasios J. Karoukis, Kecia L. Feathers, Robin R. Ali, Debra A. Thompson, Abigail T. Fahim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The retinal pigment epithelium (RPE) is a polarized monolayer that secretes growth factors and cytokines towards the retina apically and the choroid basolaterally. Numerous RPE secreted proteins have been linked to the pathogenesis of age-re
Externí odkaz:
https://doaj.org/article/6ff88f32799141fea6e94fdb2912f7c1
Autor:
Kecia L. Feathers, Lin Jia, Naheed W. Khan, Alexander J. Smith, Jian-Xing Ma, Robin R. Ali, Debra A. Thompson
Publikováno v:
Human Gene Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1246754c79a829a7f249c80ede73be3b
https://doi.org/10.1089/hum.2022.240
https://doi.org/10.1089/hum.2022.240
Autor:
Adrienne Chen, Kecia L. Feathers, Abigail T. Fahim, Debra A. Thompson, Naheed W. Khan, Feriel Presswalla, Nirosha Dayanthi Perera, Lin Jia, Robin R. Ali, Alexander J. Smith
Publikováno v:
Hum Gene Ther
Early-onset severe retinal dystrophy (EOSRD) is a genetically heterogeneous group of diseases resulting in serious visual disability in children. A significant number of EOSRD cases, often diagnosed as Leber congenital amaurosis (LCA13), are associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fa435b433f603c4ce1271f2a1314ec
https://europepmc.org/articles/PMC6854515/
https://europepmc.org/articles/PMC6854515/
Autor:
Daniel J. Klionsky, Lin Jia, Naheed W. Khan, Thomas A. Ferguson, Cheng-mao Lin, David N. Zacks, Jingyu Yao, Kecia L. Feathers
Publikováno v:
Autophagy. 12:2439-2450
Autophagy is a lysosomal degradation pathway critical to preventing the accumulation of cytotoxic proteins. Deletion of the essential autophagy gene Atg5 from the rod photoreceptors of the retina (atg5Δrod mouse) results in the accumulation of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a34600acd31ee5a1648edcaaab81f8f
https://doi.org/10.1080/15548627.2016.1238553
https://doi.org/10.1080/15548627.2016.1238553
Autor:
David N. Zacks, Xu Cao, Jason Miller, Kecia L. Feathers, Bret A. Hughes, Feriel Presswalla, Debra A. Thompson, Qitao Zhang
Publikováno v:
Experimental eye research. 178
The daily shedding and renewal of photoreceptor outer segments (OS) is critical for maintaining vision. This process relies on the efficient uptake, degradation, and sorting of shed OS material by the retinal pigment epithelium (RPE). Poor OS degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf98addf33cfe3f6057c6511abd5fe3
https://pubmed.ncbi.nlm.nih.gov/30336126
https://pubmed.ncbi.nlm.nih.gov/30336126
Autor:
N Dayanthi Perera, Kari H. Branham, Robin R. Ali, Mark E. Pennesi, Abigail T. Fahim, Michel Michaelides, Neruban Kumaran, John R. Heckenlively, Debra A. Thompson, Kecia L. Feathers, Zaina Ibrahim Bouzia, Mauricio E Vargas, Andrew R. Webster, Kelly Z. Young, Naheed W. Khan
Publikováno v:
British Journal of Ophthalmology. :bjophthalmol-2018
BackgroundDefects in retinol dehydrogenase 12 (RDH12) account for 3.4%–10.5 % of Leber congenital amaurosis and early-onset severe retinal dystrophy (EOSRD) and are a potential target for gene therapy. Clinical trials in inherited retinal diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b72912521f6cdc023a3b24f8dd3c3636
https://doi.org/10.1136/bjophthalmol-2018-313580
https://doi.org/10.1136/bjophthalmol-2018-313580
Autor:
Michaela Schweizer, Jana Schroth, Kecia L. Feathers, Sergej Skosyrski, Debra A. Thompson, Ingo Kurth, J. D. Chrispell, Andreas Gal, Christian A. Hübner, Klaus Rüther, Christina L. McHenry
Publikováno v:
Molecular and Cellular Biology. 27:1370-1379
RDH12 codes for a member of the family of short-chain alcohol dehydrogenases/reductases proposed to function in the visual cycle that supplies the chromophore 11-cis retinal to photoreceptor cells. Mutations in RDH12 cause severe and progressive chil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a248067c2a3b75d5a5d8d4edce42356
https://doi.org/10.1128/mcb.01486-06
https://doi.org/10.1128/mcb.01486-06
Autor:
Debra A. Thompson, Kecia L. Feathers, Jason Miller, Anna M. Ganios, Shameka J. Shelby, Lin Jia
Publikováno v:
Experimental eye research. 140
Photoreceptor outer segments (OS) in the vertebrate retina undergo a process of continual renewal involving shedding of disc membranes that are cleared by phagocytic uptake into the retinal pigment epithelium (RPE). In dystrophic Royal College of Sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d6887b62923af33f6b85076c5f4cf4
https://pubmed.ncbi.nlm.nih.gov/26283020
https://pubmed.ncbi.nlm.nih.gov/26283020
Autor:
Christina L. McHenry, Andreas Gal, Yuhui Liu, Anita R. Nair, Wei Feng, Debra A. Thompson, Xiaoling Ding, Kecia L. Feathers, Paul A. Sieving, Douglas Vollrath
Publikováno v:
Investigative Ophthalmology & Visual Science. 45:1456-1463
PURPOSE. Mutations in the MERTK gene are responsible for retinal degeneration in the Royal College of Surgeons (RCS) rat and are a cause of human autosomal recessive retinitis pigmentosa (RP). This study reports the identification and functional anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1dd535a293cae310c837e88ebe06879
https://doi.org/10.1167/iovs.03-0909
https://doi.org/10.1167/iovs.03-0909