The force loading rate drives cell mechanosensing through both reinforcement and fluidization

Autor: Andreu, I., Falcones, B., Hurst, S., Chahare, N., Quiroga, X., Roux, A.-L.L., Kechagia, Z., Beedle, A.E.M., Elósegui-Artola, A., Trepat, X., Farré, R., Betz, T., Almendros, I., Roca-Cusachs, P.

Publikováno v: Nature Communications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::fecfa842fc7e762101069d08b3c220f4

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Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton.

Autor: Beedle AEM; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; Department of Physics, King's College London, London WC2R 2LS, UK., Jaganathan A; Center for Engineering Mechanobiology and Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104., Albajar-Sigalés A; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Yavitt FM; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303 USA., Bera K; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303 USA., Andreu I; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, E-48940, Leioa, Spain.; Ikerbasque, Basque Foundation for Science, 48013, Bilbao, Spain., Granero-Moya I; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Zalvidea D; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain., Kechagia Z; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; Department of Biochemistry, University of Zurich, Zurich, Switzerland., Wiche G; Max Perutz Laboratories, Department of Biochemistry and Cell Biology, University of Vienna, 1030 Vienna, Austria., Trepat X; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; University of Barcelona, 08028 Barcelona, Spain., Ivaska J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Department of Life Technologies, University of Turku, FI-20520 Turku, Finland.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland.; Foundation for the Finnish Cancer Institute, Tukholmankatu 8, FI-00014 Helsinki, Finland., Anseth KS; Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA.; BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303 USA., Shenoy VB; Center for Engineering Mechanobiology and Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104., Roca-Cusachs P; Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.; University of Barcelona, 08028 Barcelona, Spain.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 11. Date of Electronic Publication: 2023 Nov 11.