Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Keavy, Daniel J."'
Autor:
Epperson, James R., Bruce, Marc A., Catt, John D., Deskus, Jeffrey A., Hodges, Donald B., Karageorge, George N., Keavy, Daniel J., Mahle, Cathy D., Mattson, Ronald J., Ortiz, Astrid A., Parker, Michael F., Takaki, Katherine S., Watson, Brett T., Joseph P.Yevich
Publikováno v:
In Bioorganic & Medicinal Chemistry 2004 12(17):4601-4611
Akademický článek
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Autor:
Kevin M. Felsenstein, Joanne J. Bronson, C.V.C. Prasad, Graham Johnson, Donna M. Barten, Michael F. Parker, Jason A. Corsa, Jeremy Mock, Valerie Guss, David W. Smith, Charles P. Sloan, Williams Andrew, Owen Brendan Wallace, Steven Hansel, Craig Polson, Keavy Daniel J, Milind Deshpande, Bergstrom Carl P, Henry H. Wang, Wai Y. Lau, Ming Zheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4432-4436
A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4e4c718d573bc4fecf0106868fda33
https://doi.org/10.1016/j.bmcl.2007.06.022
https://doi.org/10.1016/j.bmcl.2007.06.022
Autor:
Suresh Yeola, Suzanne Wehrli, Keavy Daniel J, Craig Polson, Vikram Roongta, Ming Zheng, James Mitroka, Charles P. Sloan, Donglu Zhang, Qi Gao, Douglas D. Dischino, Ronald L. Hanson
Publikováno v:
Current Drug Metabolism. 7:883-896
BMS-299897 is a gamma-secretase inhibitor that has the potential for treatment of Alzheimer's disease. The metabolism of [(14)C]BMS-299897 was investigated in human liver microsomes, in rat, dog, monkey and human hepatocytes and in bile duct cannulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a683d165023a181672b5f21dd531a66
https://doi.org/10.2174/138920006779010566
https://doi.org/10.2174/138920006779010566
Autor:
Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Dee, Michael F., Gai, Yonghua, Guss, Valerie L., Higgins, Mendi A., Keavy, Daniel J., Loo, Alice, Mate, Robert A., Marcin, Larry R., McElhone, Katharine E., Polson, Craig T., Roberts, Susan B., Macor, John E.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 November 2012 22(22):6828-6831
Autor:
Brett T. Watson, John D. Catt, Donald B. Hodges, Ronald J. Mattson, Karageorge George N, Joseph P Yevich, Astrid A. Ortiz, Jeffrey A. Deskus, Cathy D. Mahle, Keavy Daniel J, Katherine S. Takaki, James R. Epperson, Michael F. Parker, Marc Bruce
Publikováno v:
Bioorganicmedicinal chemistry. 12(17)
A series of fluoren-9-yl ethyl amides ( 2 ) were synthesized and evaluated for human melatonin MT 1 and MT 2 receptor binding. N -[2-(2,7-dimethoxyfluoren-9-yl)ethyl]propanamide ( 2b ) was selected and evaluated in functional assays measuring intrins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7114c043561d3ff3d8569a5566031e35
https://pubmed.ncbi.nlm.nih.gov/15358287
https://pubmed.ncbi.nlm.nih.gov/15358287
Autor:
Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Deshpande, Milind S., Felsenstein, Kevin M., Guss, Valerie L., Hansel, Steven B., Johnson, Graham, Keavy, Daniel J., Lau, Wai Y., Mock, Jeremy, Prasad, C.V.C., Polson, Craig T., Sloan, Charles P., Smith, David W., Wallace, Owen B., Wang, Henry H., Williams, Andrew, Zheng, Ming
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 August 2007 17(16):4432-4436
Autor:
Gribble, Gordon W., Saulnier, Mark G., Pelkey, Erin T., Kishbaugh, Tara L.S., Liu, Yanbing, Jiang, Jun, Trujillo, Hernando A., Keavy, Daniel J., Davis, Deborah A., Conway, Sam C., Switzer, Frank L., Roy, Sujata, Silva, Richard A., Obaza-Nutaitis, Judy A., Sibi, Mukund P., Moskalev, Nikolai V., Barden, Timothy C., Chang, Louis, Habeski (nee Simon), Wendy M., Pelcman, Benjamin, Sponholtz, William R., Chau, Ryan W., Allison, Brett D., Garaas, Sarah D., Sinha, Michael S., McGowan, Meredeth A., Reese, Matthew R., Harpp, Karen S.
Publikováno v:
Current Organic Chemistry; October 2005, Vol. 9 Issue: 15 p1493-1519, 27p
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Gribble, Gordon W., Saulnier, Mark G., Pelkey, Erin T., Kishbaugh, Tara L. S., Liu, Yanbing, Jiang, Jun, Trujillo, Hernando A., Keavy, Daniel J., Davis, Deborah A., Conway, Sam C., et al., et al.
Publikováno v:
ChemInform; Aug2006, Vol. 37 Issue 34, pno-no, 1p