p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response

Autor: Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Mutations in the gene encoding iRHOM2 are associated with hyperproliferative epidermal disorders. Here, the authors show that iRHOM2 is a target gene of p63, that together they regulate inflammation, cell survival and response to oxidative stress, an

Externí odkaz: https://doaj.org/article/c3aea6eca2d04247a2f4d1f9bed1b658

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

Autor: Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun

Publikováno v: PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)

Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh

Externí odkaz: https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d

Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome

Autor: Malcolm Finlay, Diogo Santos, Christopher L.-H. Huang, Vishal Vyas, Andrew A. Grace, Pier D. Lambiase, Peter Taggart, Andrew Tinker, J Bhar-Amato, Keat-Eng Ng, Michele Orini

Publikováno v: Am J Physiol Cell Physiol

A murine line haploinsufficient in the cardiac sodium channel has been used to model human Brugada syndrome: a disease causing sudden cardiac death due to lethal ventricular arrhythmias. We explored the effects of cholinergic tone on electrophysiolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5eb2290a9253621ceda28f50b88e12d
https://doi.org/10.1152/ajpcell.00028.2019

RNA sequencing-based transcriptome profiling of cardiac tissue Implicados novela putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy

Autor: Esther Zorio, Charlotte L. Hall, Matthew J. Robertson, Juan Hernandez, Ruth C. Lovering, Juan R. Gimeno, Paul J. Delaney, Mari Paz Suarez, Ali J. Marian, Pilar Molina, Francisco J. Pastor, María Sabater-Molina, Petros Syrris, Cristian Coarfa, Angeliki Asimaki, William J. McKenna, Marta Futema, Priyatansh Gurha, Beatriz Aguilera, Keat-Eng Ng, Sirisha Cheedipudi

Publikováno v: Hall, Charlotte L. Gurha, Priyatansh Sabater-Molina, Maria Asimaki, Angeliki Futema, Marta Lovering, Ruth C. Suárez, Mari Paz Aguilera, Beatriz Molina Aguilar, Pilar Zorio Grima, Esther Coarfa, Cristian Robertson, Matthew J. Cheedipudi, Sirisha M. Keat-Eng Ng. Delaney, Paul Hernández, Juan Pedro Pastor, Francisco Gimeno, Juan R. McKenna, William J. Marian, Ali J. Syrris, Petros 2020 RNA sequencing-based transcriptome profiling of cardiac tissue Implicados novela putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy. International Journal of Cardiology 302 124 130
RODERIC: Repositorio Institucional de la Universitat de Valéncia
instname
RODERIC. Repositorio Institucional de la Universitat de Valéncia
INTERNATIONAL JOURNAL OF CARDIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Int J Cardiol

Arrhythmogenic cardiomyopathy (ACM) encompasses a group of inherited cardiomyopathies including arrhythmogenic right ventricular cardiomyopathy (ARVC) whose molecular disease mechanism is associated with dysregulation of the canonical WNT signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971ca3062240f0a47d9688e77064cb0f
https://hdl.handle.net/10550/78744

MLP (muscle LIM protein) as a stress sensor in the heart

Autor: Keat-Eng Ng, Ching-Hsin Ku, Izabela Piotrowska, Byambajav Buyandelger, Snjezana Miocic, Sylvia Gunkel, Ralph Knöll

Publikováno v: Pflugers Archiv

Muscle LIM protein (MLP, also known as cysteine rich protein 3 (CSRP3, CRP3)) is a muscle-specific-expressed LIM-only protein. It consists of 194 amino-acids and has been described initially as a factor involved in myogenesis (Arber et al. Cell 79:22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8bc80eb25ae1733a6e420aa225aecd
https://doi.org/10.1007/s00424-011-0961-2