Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Keat Theng Chow"'
Autor:
Christina Yong Xin Kang, Keat Theng Chow, Yuan Siang Lui, Antoine Salome, Baptiste Boit, Philippe Lefevre, Tze Ning Hiew, Rajeev Gokhale, Paul Wan Sia Heng
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1167 (2024)
Background/Objectives: Hydroxypropyl methylcellulose (HPMC) is one of the most commonly used hydrophilic polymers in formulations of matrix tablets for controlled release applications. However, HPMC attracts moisture and poses issues with drug stabil
Externí odkaz:
https://doaj.org/article/a8f09c73dffb401c9ee3cbfc82be9a24
Autor:
Jiayi Huang, Shiqi Hong, Lucas Yuan Hao Goh, Hailong Zhang, Tao Peng, Keat Theng Chow, Rajeev Gokhale, Vinod Tuliani
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 528 (2024)
Monoclonal antibodies require careful formulation due to their inherent stability limitations. Polysorbates are commonly used to stabilize mAbs, but they are prone to degradation, which results in unwanted impurities. KLEPTOSE® HPβCD (hydroxypropyl
Externí odkaz:
https://doaj.org/article/055446672f934e6b997e5dee6c01110b
Autor:
Hailong Zhang, Shiqi Hong, Sarah Si Kai Tan, Tao Peng, Lucas Yuan Hao Goh, Kwan Hang Lam, Keat Theng Chow, Rajeev Gokhale
Publikováno v:
Molecules, Vol 27, Iss 19, p 6497 (2022)
Polysorbates (PS 20 and PS 80) are the most widely used surfactants in biopharmaceutical formulations to protect proteins from denaturation, aggregation, and surface adsorption. To date, around 70% of marketed therapeutic antibodies contain either PS
Externí odkaz:
https://doaj.org/article/cf124ec3ca134181916a382b3c0b98c0
Publikováno v:
Handbook of Pharmaceutical Granulation Technology ISBN: 9780429320057
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9225d773184e63c4f270ec5dcca4335
https://doi.org/10.1201/9780429320057-9-11
https://doi.org/10.1201/9780429320057-9-11
Publikováno v:
Functionalized Nanomaterials II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2390e77ee9a8f530b35b36daf72de5fa
https://doi.org/10.1201/9781351021388-1
https://doi.org/10.1201/9781351021388-1
Publikováno v:
Journal of Drug Delivery Science and Technology. 24:205-211
Thin film freezing is a particle engineering technology for the production of nanostructured amorphous solid dispersions. In the present study, we investigated the use of thin film freezing technology in combination with template emulsion to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58f3a8472d2cd3c8e3b2b017cb309c16
https://doi.org/10.1016/s1773-2247(14)50033-0
https://doi.org/10.1016/s1773-2247(14)50033-0
Publikováno v:
AAPS PharmSciTech. 13:949-960
Nanoparticles, of the poorly water-soluble drug, itraconazole (ITZ), were produced by the Advanced Evaporative Precipitation into Aqueous Solution process (Advanced EPAS). This process combines emulsion templating and EPAS processing to provide impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d44e98e6f0b2006365fb56da58e3f41
https://doi.org/10.1208/s12249-012-9817-0
https://doi.org/10.1208/s12249-012-9817-0
Autor:
Stefan Kasapis, Paul Wan Sia Heng, Keat Theng Chow, Lai Peng Leong, Lilia Bruno, Vinita Chaudhary
Publikováno v:
Carbohydrate Polymers. 86:644-651
The structural properties of ethyl cellulose and propylene glycol dicaprylate mixtures were investigated with a view to facilitating use of the system as excepient for topical drug delivery. The working protocol included small-deformation dynamic osc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b7b6cec21fee2f43c5fff1e9e7e44da
https://doi.org/10.1016/j.carbpol.2011.05.002
https://doi.org/10.1016/j.carbpol.2011.05.002
Publikováno v:
Pharmaceutical Research. 25:207-217
This study was aimed at formulating a hydrophilic non-aqueous gel for topical delivery of the model moisture-sensitive drug, minocycline hydrochloride (MH).Stability study of MH dissolved in water and various hydrophilic non-aqueous solvents was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0a680f414ea5e219b3378010121f7b
https://doi.org/10.1007/s11095-007-9457-3
https://doi.org/10.1007/s11095-007-9457-3
Publikováno v:
Pharmaceutical Research. 22:676-684
This study reports the rheological and mechanical characterization of novel non-aqueous ethylcellulose gel matrices intended for topical drug delivery. An attempt was also made to explain the molecular interaction within the gel systems from a molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21193c6fe7a80ba829b3edd41c73bea5
https://doi.org/10.1007/s11095-005-2484-z
https://doi.org/10.1007/s11095-005-2484-z