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Akademický článek

Developing Clinical Risk Prediction Models for Worsening Heart Failure Events and Death by Left Ventricular Ejection Fraction

Autor: Rishi V. Parikh, Alan S. Go, Ankeet S. Bhatt, Thida C. Tan, Amanda R. Allen, Kent Y. Feng, Steven A. Hamilton, Andrew S. Tai, Jesse K. Fitzpatrick, Keane K. Lee, Sirtaz Adatya, Harshith R. Avula, Dana R. Sax, Xian Shen, Joaquim Cristino, Alexander T. Sandhu, Paul A. Heidenreich, Andrew P. Ambrosy

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)

Background There is a need to develop electronic health record–based predictive models for worsening heart failure (WHF) events across clinical settings and across the spectrum of left ventricular ejection fraction (LVEF). Methods and Results We st

Externí odkaz: https://doaj.org/article/01b708908f5f4ebb981fd04d26df5734

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Akademický článek

Magnetic resonance imaging for characterization of hepatocellular carcinoma metabolism

Autor: Lixia Wang, Ju Dong Yang, Charles C. Yoo, Keane K. Y. Lai, Jonathan Braun, Dermot P. B. McGovern, Yibin Xie, Stephen J. Pandol, Shelly C. Lu, Debiao Li

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

With a better understanding of the pathophysiological and metabolic changes in hepatocellular carcinoma (HCC), multiparametric and novel functional magnetic resonance (MR) and positron emission tomography (PET) techniques have received wide interest

Externí odkaz: https://doaj.org/article/02527324461243f89230a510b70ca24f

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Akademický článek

Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma

Autor: Fung-Yu Huang, Danny Ka-Ho Wong, Vivien Wai-Man Tsui, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Keane K.-Y. Lai, Man-Fung Yuen

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background Hepatitis B virus (HBV) is the major risk factor for hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV-associated HCC pathogenesis is still unclear. Genetic alterations in cancer-related genes have been linke

Externí odkaz: https://doaj.org/article/52b4b0b91b2b44618f0cbd4e559ccbf5

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Akademický článek

Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage.

Autor: Masaya Ono, Keane K Y Lai, Kaijin Wu, Cu Nguyen, David P Lin, Ramachandran Murali, Michael Kahn

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200714 (2018)

Over 400 million years ago, the evolution of vertebrates gave rise to a life cycle in which the organism began to live longer particularly as an adult. To accommodate such a longer lifespan, the organism underwent adaptation, developing a mechanism f

Externí odkaz: https://doaj.org/article/3d4df806527a493989b4487e968050c1

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Akademický článek

Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models.

Autor: Keane K Y Lai, Sufen Shang, Neha Lohia, Garrett C Booth, Derek J Masse, Nelson Fausto, Jean S Campbell, Laura Beretta

Publikováno v: PLoS Genetics, Vol 7, Iss 6, p e1002147 (2011)

We are reporting qualitative and quantitative changes of the extracellular matrix (ECM) and associated receptor proteomes, occurring during the transition from liver fibrosis and steatohepatitis to hepatocellular carcinoma (HCC). We compared two mous

Externí odkaz: https://doaj.org/article/5258cb402eac4817bea94b8bdac88168

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