Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Ke-Wu Yang"'
Publikováno v:
ACS Omega, Vol 5, Iss 34, Pp 21570-21578 (2020)
Externí odkaz:
https://doaj.org/article/6cbf4301f37944549ad2caa6751f7250
Autor:
Le Zhai, Ya Liu, Yue Jiang, Ling-Yan Kong, Jian Xiao, Yi-Xue Wang, Yang Shi, Yi-Lin Zhang, Ke-Wu Yang
Publikováno v:
Molecules, Vol 27, Iss 22, p 7685 (2022)
Multidrug-resistant bacterial infections mediated by metallo-β-lactamases (MβLs) have grown into an emergent health threat, and development of novel antimicrobials is an ideal strategy to combat the infections. Herein, a novel vancomycin derivative
Externí odkaz:
https://doaj.org/article/43e40d5e43e44a128c2451678375b56f
Publikováno v:
Antibiotics, Vol 9, Iss 3, p 99 (2020)
Metallo-β-lactamase (MβLs) mediated antibiotic resistance seriously threatens the treatment of bacterial diseases. Recently, we found that thioacetamides can be a potential MβL inhibitor skeleton. In order to improve the information of the skeleto
Externí odkaz:
https://doaj.org/article/df535a14696645e8a9bb4bb74ce906cd
Autor:
Yang Xiang, Yue-Juan Zhang, Ying Ge, Yajun Zhou, Cheng Chen, Weixiao Yuan Wahlgren, Xiangshi Tan, Xi Chen, Ke-Wu Yang
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 72 (2020)
Inhibition of β-lactamases presents a promising strategy to restore the β-lactams antibacterial activity to resistant bacteria. In this work, we found that aromatic carboxyl substituted 2-triazolylthioacetamides 1a−j inhibited VIM-2, exhibiting a
Externí odkaz:
https://doaj.org/article/89087979630147f5b60c6b5fa601368e
Publikováno v:
Brazilian Archives of Biology and Technology, Vol 56, Iss 5, Pp 811-816 (2013)
A simple and effective salting-out method was developed for the purification of the metallo-β-lactamase CcrA from Bacteroides fragilis based on the plasmid pMSZ02, in which the crude protein secreted into growth medium was precipitated by 80% sulfat
Externí odkaz:
https://doaj.org/article/ec726a01f7f04e21b7cc8bf6a87423c6
Autor:
Cheng Chen, Peter Oelschlaeger, Dongmei Wang, Hao Xu, Qian Wang, Cheng Wang, Aiguo Zhao, Ke-Wu Yang
Publikováno v:
Journal of Medicinal Chemistry. 65:5954-5974
Serine/metallo-carbapenemase-coproducing pathogens, often referred to as "superbugs", are a significant clinical problem. They hydrolyze nearly all available β-lactam antibiotics, especially carbapenems considered as last-resort antibiotics, serious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ee2ffc4b561c289def9cd4f534978f
https://doi.org/10.1021/acs.jmedchem.2c00213
https://doi.org/10.1021/acs.jmedchem.2c00213
Publikováno v:
Letters in Drug Design & Discovery. 18:76-84
Background: : The appearance of antibiotic resistance caused by metallo-β-lactamases (MβLs) is a global public health threat. Developing MβLs inhibitor is an effective way to overcome antibiotic resistance. Recently, azolylthioacetamides were repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e7f6ffdd18c576b46729358d66c2d7a
https://doi.org/10.2174/1570180817999200831094019
https://doi.org/10.2174/1570180817999200831094019
Autor:
Jian-Bin Zhen, Huan-Huan Ding, Le Zhai, Mu-Han Zhao, Le-Yun Sun, Cheng Chen, Jia-Qi Li, Jia-Zhu Chigan, Han Gao, Ke-Wu Yang
Publikováno v:
Polymer Chemistry. 12:2397-2403
The drug resistance caused due to the overuse of antibiotics has grown into an emerging threat. It is urgent to develop novel strategies to combat bacterial resistance. In this work, a quinine-based quaternized polymer with amphiphilicity (QMTA) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fde386cfdb87a6d77159e423f2251b2
https://doi.org/10.1039/d0py01751e
https://doi.org/10.1039/d0py01751e
Publikováno v:
New Journal of Chemistry. 45:20743-20750
It is imperative to develop innovative and efficient antibacterial agents, on account of the mounting prevalence of complicated infections induced by multidrug-resistant bacteria. In this work, Chol-b-Lys nanoparticles (CL-NPs) with a diameter of 304
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b63fbbfddddfc5730853f6e623adc18f
https://doi.org/10.1039/d1nj03944j
https://doi.org/10.1039/d1nj03944j
Publikováno v:
ACS omega. 7(34)
The overuse of antibiotics exacerbates the development of antibiotic-resistant bacteria, threatening global public health, while most traditional antibiotics act on specific targets and sterilize through chemical modes. Therefore, it is a desperate n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5db020d22f72736941d7dd139acafc
https://pubmed.ncbi.nlm.nih.gov/36061679
https://pubmed.ncbi.nlm.nih.gov/36061679