Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ke Wei Gong"'
Autor:
Jessica Jen-Chu Wang, Christoph Rau, Rozeta Avetisyan, Shuxun Ren, Milagros C Romay, Gabriel Stolin, Ke Wei Gong, Yibin Wang, Aldons J Lusis
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006038 (2016)
We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting. We characterized the changes in cardiac structure an
Externí odkaz:
https://doaj.org/article/07894b709ca746889fb3aef9329d6d33
Autor:
Dennis J. Slamon, Jun Zhang, Ming Lu, Ke Wei Gong, Shawnt Issakhanian, Raul Ayala, Tong Luo, Athena M. Madrid, Martina S.J. McDermott, Holly K.T. Huang, Neil A. O'Brien
Supplementary Table from Tucatinib has Selective Activity in HER2-Positive Cancers and Significant Combined Activity with Approved and Novel Breast Cancer–Targeted Therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123fdd17c5247cde91fb09a18e560b00
https://doi.org/10.1158/1535-7163.22522642
https://doi.org/10.1158/1535-7163.22522642
Autor:
Dennis J. Slamon, Jun Zhang, Ming Lu, Ke Wei Gong, Shawnt Issakhanian, Raul Ayala, Tong Luo, Athena M. Madrid, Martina S.J. McDermott, Holly K.T. Huang, Neil A. O'Brien
Pharmacologically targeting the HER2 oncoprotein with therapeutics such as the mAb, trastuzumab, provides clinical benefit for patients with HER2-positive (HER2+) cancers. However, a significant number of patients eventually progress on these therapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6befd586bcd3d1466546f9390efb869a
https://doi.org/10.1158/1535-7163.c.6543451
https://doi.org/10.1158/1535-7163.c.6543451
Autor:
William D. Tap, Ke-Wei Gong, Judy Daring, Yiou Tseng, Charles Ginther, Giovanni Pauletti, John A. Glaspy, Richard Essner, Gideon Bollag, Peter Hirth, Chao Zhang, Dennis J. Slamon
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 8, Pp 637-649 (2010)
PURPOSE: About 65% to 70% of melanomas harbor a mutation in v-raf murine sarcoma viral oncogene homolog B1 (BRAF) that causes the steady-state activation of extracellular signal-regulated kinase (ERK). We sought to investigate the efficacy of PLX4032
Externí odkaz:
https://doaj.org/article/7a929f77dfd249d2aa2687daa3b539ad
Autor:
Neil A. O'Brien, Holly K.T. Huang, Martina S.J. McDermott, Athena M. Madrid, Tong Luo, Raul Ayala, Shawnt Issakhanian, Ke Wei Gong, Ming Lu, Jun Zhang, Dennis J. Slamon
Publikováno v:
Molecular cancer therapeutics. 21(5)
Pharmacologically targeting the HER2 oncoprotein with therapeutics such as the mAb, trastuzumab, provides clinical benefit for patients with HER2-positive (HER2+) cancers. However, a significant number of patients eventually progress on these therapi
Autor:
Jennifer Erdrich, Kristel Lourdault, Alex Judd, David Kaufman, Ke Wei Gong, Melanie Gainsbury, Nan Deng, Wonwoo Shon, Richard Essner
Publikováno v:
The Journal of surgical research. 279
Histologic characteristics cannot adequately predict which patients are at risk of developing metastatic disease after excision of primary cutaneous melanoma. The aim of this study was to identify immunomodulatory genes in primary tumors associated w
Autor:
Martina S. McDermott, Ke Wei Gong, Neil A. O'Brien, Dylan Conklin, Benjamin Hoffstrom, Ming Lu, Jun Zhang, Tong Luo, Weiping Jia, Jenny J. Hong, Kevin Chau, Simon Davenport, Michael F. Press, Abram Handly-Santana, Joan S. Brugge, Ronny Drapkin, John A. Glaspy, Leonard Presta, Dennis J. Slamon
Publikováno v:
Cancer Research. 82:342-342
Background: Claudin 6 (CLDN6), a member of the claudin family of tight junction proteins, is expressed at high levels in multiple human malignancies including ovarian and endometrial cancers. Conversely it has little or no expression in normal tissue
Autor:
Neil A. O'brien, Martina S. McDermott, Jun Zhang, Ke Wei Gong, Ming Lu, Benjamin G. Hoffstrom, Dylan Conklin, Tong Luo, Kevin Chau, Min Liang, Timothy R. Donahue, John A. Glaspy, Leonard Presta, Dennis J. Slamon
Publikováno v:
Cancer Research. 82:332-332
Background: Claudin 18 is a member of the claudin family of tight junction tetraspan cell surface proteins. The 18.2 isoform of claudin 18 (CLDN18.2) is expressed in healthy gastric mucosa cells and largely absent from other normal adult cell types.
Autor:
Neil A. O'Brien, Holly K. Huang, Martina S. McDermott, Athena Madrid, Tong Luo, Raul Ayala, Shawnt Issakhanian, Ke Wei Gong, Ming Lu, Jun Zhang, Dennis J. Slamon
Publikováno v:
Cancer Research. 82:LB197-LB197
Pharmacologically targeting the HER2 oncoprotein with therapeutics such as the monoclonal antibody (mAb), trastuzumab, provides clinical benefit for patients with HER2-positive (HER2+) cancers. However, a significant number of patients eventually pro
Autor:
Jerzy W. Kupiec-Weglinski, Takehiro Fujii, Dawoud Sulaiman, Subhashini Bolisetty, Min Zhang, Ke Wei Gong, Jesus A. Araujo, Akeem O. Lawal, Kojiro Nakamura, Shoichi Kageyama, Hirofumi Hirao, May Bhetraratana
Publikováno v:
JCI insight, vol 3, iss 19
Macrophages polarize into heterogeneous proinflammatory M1 and antiinflammatory M2 subtypes. Heme oxygenase 1 (HO-1) protects against inflammatory processes such as ischemia-reperfusion injury (IRI), organ transplantation, and atherosclerosis. To tes