Výsledky vyhledávání

BRMS1 in gliomas – an expression analysis

Autor: Feldheim, JJ, Feldheim, J, Keßler, AF, Glas, M, Ernestus, RI, Monoranu, CM, Löhr, M, Hagemann, C

Publikováno v: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV174 /20220525/

Objective: Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system. Up to this day, patients diagnosed with GBM face an unfavorable prognosis, even with the intense standard treatment consisting of surgi

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Tumour Treating Fields (TTFields) promotes Rho kinase-dependent phosphorylation of the tight junction protein claudin-5

Autor: Salvador, E, Keßler, AF, Burek, M, Tempel Brami, C, Voloshin-Sela, T, Volodin, A, Adel, Z, Giladi, M, Ernestus, RI, Löhr, M, Förster, C, Hagemann, C

Objective: Tumor Treating Fields (TTFields) are alternating electrical fields that are approved and effective for glioblastoma therapy with a frequency of 200 kHz. At a frequency of 100 kHz, we have previously shown that TTFields can transiently open

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Intraoperative-moulded- vs. CAD-CAM-cranioplasty after decompressive craniectomy – a retrospective single-centre analysis of 258 cases with regard to perioperative modalities as well as short- and long-term complication rates and aesthetic results

Autor: Hädrich, D, Westermaier, T, Cattaneo, A, Keßler, AF, Ernestus, RI, Pakos, P, Lilla, N

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCP006 /20210604/

Objective: Cranioplasty (CP) after decompressive craniectomy (DC) restores the functionality and aesthetic of the patients cranial vault. Although it is a routine procedure, high complication rates have been described, partly related to the type of i

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Analysis of a platform for exchange of patients’ expertise in TTFields practice to improve quality-of-life in high-grade glioma patients

Autor: Keßler, AF, Weiland, J, Dufner, V, Lilla, N, Linsenmann, T, Westermaier, T, Hagemann, C, Ernestus, RI, Löhr, M, Jentschke, E

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCV018 /20200626/

Objective: Glioblastoma (GBM) Patients and their Relatives (PaR) face tremendous distress and psychological burden due to limited survival and neurological/neuropsychological deficits. Tumor Treating Fields (TTFields, alternating electric fields at 2

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Ribosomal protein S27 (RPS27) – A new marker for astrocytic tumours?

Autor: Feldheim, J, Kessler, AF, Monoranu, C, Krapp, J, Schmitt, D, Wilczek, L, Ernestus, RI, Löhr, M, Hagemann, C

Publikováno v: 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie; 20190512-20190515; Würzburg; DOCV255 /20190508/

Objective: Ribosomal protein S27 (RPS27) shows a strong nuclear staining in Purkinje cells. However, it has been reported to be mutated or overexpressed in multiple human cancers, such as colon or breast cancer. In melanoma, RPS27 mutations are even

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The BReMen trial –impact of rehabilitation in patients after resection of a benign meningioma

Autor: Krause, K, Keßler, AF, Al-Shameri, B, Weiland, J, Linsenmann, T, Hagemann, C, Ernestus, RI, Löhr, M, Jentschke, E

Objective: Despite the good prognosis of benign meningioma, evidence for eventual impairment of patients’ psychological quality of life (pQoL), social and neuropsychological functioning after surgery becomes more and more apparent. These patients m

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Plasma levels of circulating MACC1 transcripts cosegregate with other prognostic markers and treatment response in glioblastoma patients

Autor: Hagemann, C, Neuhaus, N, Dahlmann, M, Kessler, AF, Kobelt, D, Herrmann, P, Eyrich, M, Freitag, B, Monoranu, CM, Ernestus, RI, Löhr, M, Stein, U

Publikováno v: 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie; 20180603-20180606; Münster; DOCP091 /20180618/

Objective: IDH1-mutation and MGMT-promoter methylation are established prognostic markers in Glioblastoma multiforme (GBM). However, invasive procedures are needed to obtain the required tumor tissue. Metastasis-associated in colon cancer-1 (MACC1) c

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Expression of activating transcription factor 5 (ATF5) is increased in astrocytomas of different WHO grades and correlates with survival of glioblastoma patients

Autor: Feldheim J, Kessler AF, Schmitt D, Wilczek L, Linsenmann T, Dahlmann M, Monoranu CM, Ernestus RI, Hagemann C, Löhr M

Publikováno v: OncoTargets and Therapy, Vol Volume 11, Pp 8673-8684 (2018)

Jonas Feldheim,1 Almuth F Kessler,1 Dominik Schmitt,1 Lara Wilczek,1 Thomas Linsenmann,1 Mathias Dahlmann,2,3 Camelia M Monoranu,4 Ralf-Ingo Ernestus,1 Carsten Hagemann,1,* Mario Löhr1,* 1Department of Neurosurgery, Tumorbiology Laboratory, Univer

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https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-177541

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Treatment options for adult patients with anaplastic pilocytic astrocytomas WHO°III

Autor: Kessler, AF, Feldheim, J, Linsenmann, T, Hagemann, C, Ernestus, RI, Löhr, M

Publikováno v: 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS); 20160612-20160615; Frankfurt am Main; DOCP 119 /20160608/

Objective: Due to its rareness, there is uncertainty about the clinical course and adjuvant therapy-options of anaplastic pilocytic astrocytoma WHO°III (APA). Whereas in pilocytic astrocytoma WHO °I (PA) the prognosis remains comparatively well eve

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Activating transcription factor 5 – a new therapeutic target for treatment of astrocytomas?

Autor: Feldheim, J, Keßler, AF, Hagemann, C, Linsenmann, T, Ernestus, RI, Löhr, M

Objective: Activating transcription factor 5 (ATF5) is a widely expressed basic leucine zipper protein, that is known to suppress differentiation of neuroprogenitor cells into neurons or glia in the normal brain (NB) and has been reported to be overe

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