PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

Autor: Wang, Lin, Wang, Dan, Sonzogni, Olmo, Ke, Shizhong, Wang, Qi, Thavamani, Abhishek, Batalini, Felipe, Stopka, Sylwia A., Regan, Michael S., Vandal, Steven, Tian, Shengya, Pinto, Jocelin, Cyr, Andrew M., Bret-Mounet, Vanessa C., Baquer, Gerard, Eikesdal, Hans P., Yuan, Min, Asara, John M., Heng, Yujing J., Bai, Peter, Agar, Nathalie Y.R., Wulf, Gerburg M.

Publikováno v: In Cell Reports 11 October 2022 41(2)

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

Autor: Koikawa, Kazuhiro, Kibe, Shin, Suizu, Futoshi, Sekino, Nobufumi, Kim, Nami, Manz, Theresa D., Pinch, Benika J., Akshinthala, Dipikaa, Verma, Ana, Gaglia, Giorgio, Nezu, Yutaka, Ke, Shizhong, Qiu, Chenxi, Ohuchida, Kenoki, Oda, Yoshinao, Lee, Tae Ho, Wegiel, Babara, Clohessy, John G., London, Nir, Santagata, Sandro, Wulf, Gerburg M., Hidalgo, Manuel, Muthuswamy, Senthil K., Nakamura, Masafumi, Gray, Nathanael S., Zhou, Xiao Zhen, Lu, Kun Ping

Publikováno v: In Cell 2 September 2021 184(18):4753-4771

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Inhibition of CK1ε potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer.

Autor: Dang, Fabin, Nie, Li, Zhou, Jin, Shimizu, Kouhei, Chu, Chen, Wu, Zhong, Fassl, Anne, Ke, Shizhong, Wang, Yuangao, Zhang, Jinfang, Zhang, Tao, Tu, Zhenbo, Inuzuka, Hiroyuki, Sicinski, Piotr, Bass, Adam J., Wei, Wenyi

Publikováno v: Nature Communications; 9/10/2021, Vol. 12 Issue 1, p1-15, 15p

Reciprocal inhibition of PIN1 and APC/C CDH1 controls timely G1/S transition and creates therapeutic vulnerability.

Autor: Ke S; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; These authors contributed equally to this work., Dang F; Department of Pathology, Beth Israel Deaconess Medical Center and Cancer Research Institute, Harvard Medical School, Boston, MA 02215, USA.; These authors contributed equally to this work., Wang L; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; These authors contributed equally to this work., Chen JY; Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02215, USA.; These authors contributed equally to this work., Naik MT; Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI 02912, USA., Thavamani A; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Liu Y; Yale Cancer Biology Institute, West Haven, CT 06516, USA.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510., Li W; Yale Cancer Biology Institute, West Haven, CT 06516, USA., Kim N; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Naik NM; Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI 02912, USA., Sui H; Key Laboratory of Functional and Clinical Translational Medicine, Fujian Province University, Xiamen Medical College, Xiamen 361023, China., Tang W; Data Science & Artificial Intelligence, R&D, AstraZeneca, Gaithersburg, USA., Qiu C; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Koikawa K; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Batalini F; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Department of Medicine, Division of Medical Oncology, Mayo Clinic, Arizona, USA., Wang X; Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Clohessy JG; Preclinical Murine Pharmacogenetics Facility, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Heng YJ; Department of Pathology, Beth Israel Deaconess Medical Center and Cancer Research Institute, Harvard Medical School, Boston, MA 02215, USA., Lahav G; Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA., Gray NS; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA., Zho XZ; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Departments of Biochemistry & Oncology, Schulich School of Medicine and Dentistry, and Robarts Research Institute, Western University, London, ON N6A 3K7, Canada., Wei W; Department of Pathology, Beth Israel Deaconess Medical Center and Cancer Research Institute, Harvard Medical School, Boston, MA 02215, USA., Wulf GM; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Lu KP; Division of Hematology/Oncology, Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Departments of Biochemistry & Oncology, Schulich School of Medicine and Dentistry, and Robarts Research Institute, Western University, London, ON N6A 3K7, Canada.; Lead Contact.

Publikováno v: Research square [Res Sq] 2023 Jan 19. Date of Electronic Publication: 2023 Jan 19.