Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Kdm4"'
Autor:
Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone, Caterina Alfano
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an impo
Externí odkaz:
https://doaj.org/article/b96d859348f0461a9deca1a52950e217
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 2, Pp n/a-n/a (2024)
Abstract Despite the remarkable clinical efficacy of cancer immunotherapy, considerable patients fail to benefit from it due to primary or acquired resistance. Tumours frequently hijack diverse epigenetic mechanisms to evade immune detection, thereby
Externí odkaz:
https://doaj.org/article/86041a81950f49c7ae59207a963ed78d
Akademický článek
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Autor:
Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung, Wen-Ching Wang
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-13 (2022)
Abstract Background Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine demethylase family 4 (K
Externí odkaz:
https://doaj.org/article/e6fc84a951a64927b29a0a1dd04a7072
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Breast cancer (BC) is the second leading cause of cancer death in women, although recent scientific and technological achievements have led to significant improvements in progression-free disease and overall survival of patients. Genetic mutations an
Externí odkaz:
https://doaj.org/article/b97fca655c0f4f52a6ba5583fbd1b552
Autor:
Aylin del Moral-Morales, Marisol Salgado-Albarrán, Elizabeth Ortiz-Gutiérrez, Gerardo Pérez-Hernández, Ernesto Soto-Reyes
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
KDM4 proteins are a subfamily of histone demethylases that target the trimethylation of lysines 9 and 36 of histone H3, which are associated with transcriptional repression and elongation respectively. Their deregulation in cancer may lead to chromat
Externí odkaz:
https://doaj.org/article/9ee02beb46274c3d83073d991713a244
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Histone methylation status is an important process associated with cell growth, survival, differentiation and gene expression in human diseases. As a member of the KDM4 family, KDM4B specifically targets H1.4K26, H3K9, H3K36, and H4K20, which affects
Externí odkaz:
https://doaj.org/article/8cbda36d242742a8b2167ebaca2e205a
Akademický článek
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Autor:
Dawid Dorna, Jarosław Paluszczak
Publikováno v:
Cells, Vol 11, Iss 6, p 1023 (2022)
Epigenetic aberrations, associated with altered DNA methylation profiles and global changes in the level of histone modifications, are commonly detected in head and neck squamous cell carcinomas (HNSCC). Recently, histone lysine demethylases have bee
Externí odkaz:
https://doaj.org/article/3619c0d286444970b7ce1228ac2641ad