Zobrazeno 1 - 10
of 419
pro vyhledávání: '"Kd Bagshawe"'
Publikováno v:
Cell Biophysics. 22:9-26
Antibody-directed enzyme prodrug therapy (ADEPT) involves two phases. The first is an antibody-enzyme conjugate that localizes to tumor. The second phase is a prodrug that is administered when the enzyme-conjugate has cleared from blood and other non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b306663dfed9c80e97e0d2b137e498b
https://doi.org/10.1007/bf03033864
https://doi.org/10.1007/bf03033864
Autor:
R. G. Melton, F. T. Boyle, P. J. Burke, S J. East, D. C. Blakey, Kd Bagshawe, B. E. Valcaccia, Caroline Joy Springer, A. F. Wright
Publikováno v:
Cell Biophysics. 22:1-8
The F(ab’)2 fragment of the antitumor monoclonal antibody, A5B7, was covalently linked to the bacterial enzyme carboxypeptidase G2 (CPG2). The resulting conjugate was used in combination with a prodrug of a benzoic acid mustard alkylating agent to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d73588f5090144944d4e64632f7add
https://doi.org/10.1007/bf03033863
https://doi.org/10.1007/bf03033863
Publikováno v:
Journal of Immunological Methods. 158:49-56
Conjugates of F(ab′) 2 fragment of the monoclonal antibody A5B7 coupled to carboxypeptidase G 2 (CPG 2 ) have been produced using the heterobifunctional reagents 2-mercapto-[ S -acetyl]acetic acid, N -hydroxysuccinimide ester (SATA) and m -maleimid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2403c999d5c76fe0ee7d847fb92ef
https://doi.org/10.1016/0022-1759(93)90257-8
https://doi.org/10.1016/0022-1759(93)90257-8
Publikováno v:
British Journal of Cancer
The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1722c558fa8489f96ae279924cc6a08
https://doi.org/10.1038/bjc.1992.379
https://doi.org/10.1038/bjc.1992.379
Autor:
Kd Bagshawe, R. H. J. Begent, N. Howells, Edward S. Newlands, B. Mcquade, D. B. Smith, G.J.S. Rustin
Publikováno v:
The Lancet. 338:487-490
Ondansetron, a serotonin antagonist, is effective in controlling the emesis associated with cancer chemotherapy; however, emesis in patients receiving high-dose cisplatin is poorly controlled by ondansetron alone. Dexamethasone is an effective antiem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e45813a0b8bf3b28219c39c7ce993f
https://doi.org/10.1016/0140-6736(91)90555-4
https://doi.org/10.1016/0140-6736(91)90555-4
Autor:
Roger F. Sherwood, Kd Bagshawe, Roger G. Melton, P Antoniw, P. J. Burke, Caroline Joy Springer, Frances Searle, G.T. Rogers
Publikováno v:
British Journal of Cancer
A novel therapy for improving selectivity in cancer chemotherapy aims to modify distribution of a cytotoxic drug by generating it selectively at tumour sites. In this approach an antibody-enzyme conjugate is allowed to localise at the tumour sites be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5a5dfd36faeff6065e0451ae0c3779
https://doi.org/10.1038/bjc.1990.407
https://doi.org/10.1038/bjc.1990.407
Autor:
Roger G. Melton, B. Mellor, Frances Searle, Roger F. Sherwood, RB Pedley, T. Bradshaw, Kd Bagshawe
Publikováno v:
Biochemical Pharmacology. 39:1787-1791
MAWI colonic cancer cells respond to sequential treatment in vitro with carboxypeptidase G2 and trimetrexate by a delay in cell growth as measured by cell numbers, but an increase in incorporation of 75-Se-selenomethionine per cell. The cells are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5daf35e08648623d1ccd76c14d455f
https://doi.org/10.1016/0006-2952(90)90126-6
https://doi.org/10.1016/0006-2952(90)90126-6
Publikováno v:
British Journal of Cancer
Studies with a conjugate of carboxypeptidase G2 (CPG2) and the F(ab')2 fragment of monoclonal anti-CEA antibody, A5B7, have shown specific localisation in a human colon tumour xenograft, LS174T, growing in nude mice. The conjugate reaches a peak conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166b29b3ed6d7b64a619e2bf7d3bb7d7
https://doi.org/10.1038/bjc.1990.149
https://doi.org/10.1038/bjc.1990.149
Publikováno v:
British Journal of Cancer
The in vivo localising and clearance properties of conjugates of the folate-degrading enzyme carboxypeptidase G2 (CPG2) with anti-human chorionic gonadotrophin (W14A) were measured in nude mice bearing CC3 choriocarcinoma xenografts. Conjugates of W1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb54cf5bc5f26a0c24ce88ec44e1037f
https://doi.org/10.1038/bjc.1990.92
https://doi.org/10.1038/bjc.1990.92
Publikováno v:
British Journal of Cancer
A trophoblast cell surface antigen has been characterised by a monoclonal antibody (mAb) 5T4, raised following immunisation with solubilised wheat germ agglutinin binding glycoproteins from human syncytiotrophoblast plasma membrane (StMPM). The expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f50b3ae1fddfdb8772e7fffb378a5b
https://doi.org/10.1038/bjc.1990.20
https://doi.org/10.1038/bjc.1990.20