TGF-β expression in the human colon: differential immunostaining along crypt epithelium

Autor: KC Flanders, A Avery, C Paraskeva, P Hall, M Sporn, M Moorghen

Publikováno v: British Journal of Cancer

Samples of colorectal carcinoma, adenoma and normal colorectal mucosa were examined for the expression of TGF-beta by immunohistochemistry. Immunoreactivity for TGF-beta was present in 52 out of a total of 58 samples of normal mucosa examined. In ade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a5892de2c9d364fe0042b6303819c5
https://doi.org/10.1038/bjc.1993.301

Release of a transforming growth factor (TGF)-beta 2-related suppressor factor from postimplantation murine decidual tissue can be correlated with the detection of a subpopulation of cells containing RNA for TGF-beta 2

Autor: Richard Lea, Kc, Flanders, Cb, Harley, Manuel J, Banwatt D, Da, Clark

Publikováno v: Europe PubMed Central

Postimplantation murine decidual tissue from allopregnant C3H mice has been shown to release in vitro a potent immunosuppressive factor closely related to transforming growth factor (TGF)-beta 2 but slightly lower in apparent molecular weight. Decidu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7bc17a40624a66ee56fee69c98adef6b
https://pubmed.ncbi.nlm.nih.gov/1730871

The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ.

Autor: Yang Y; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Yang HH; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Tang B; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Wu AML; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Flanders KC; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Moshkovich N; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Weinberg DS; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Welsh MA; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Weng J; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Ochoa HJ; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Hu TY; Collaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Herrmann MA; Collaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Chen J; Collaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Edmondson EF; Pathology Histotechnology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Simpson RM; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Liu F; Center for Advanced Biotechnology and Medicine, Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, New Jersey., Liu H; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Lee MP; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Wakefield LM; Lab of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. wakefiel@dce41.nci.nih.gov.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Feb 01; Vol. 26 (3), pp. 643-656. Date of Electronic Publication: 2019 Oct 03.

Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1.

Autor: Zhang H; Cardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts., Du L; Cardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts., Zhong Y; Cardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts., Flanders KC; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and., Roberts JD Jr; Cardiovascular Research Center of the General Medical Services, Massachusetts General Hospital, Boston, Massachusetts; roberts@cvrc.mgh.harvard.edu.; Department of Anesthesia and the Division of Newborn Medicine in the Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2017 Sep 01; Vol. 313 (3), pp. L615-L627. Date of Electronic Publication: 2017 Jun 22.

Inhibition of development of laser-induced choroidal neovascularization with suppression of infiltration of macrophages in Smad3-null mice.

Autor: Iwanishi H; Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan., Fujita N; Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan., Tomoyose K; Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan., Okada Y; Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan., Yamanaka O; Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan., Flanders KC; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Saika S; Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2016 Jun; Vol. 96 (6), pp. 641-51. Date of Electronic Publication: 2016 Mar 07.