Výsledky vyhledávání

α2HS-glycoprotein, an Antagonist of Transforming Growth Factor β In vivo , Inhibits Intestinal Tumor Progression

Autor: Carol J. Swallow, Jennifer C. Macmillan, Melanie Szweras, James W. Dennis, Tania Tajirian, Kazy Hay, Emily A. Partridge, Steven Gallinger, Mark Redston, Willi Jahnen-Dechent, Gianni M. DiGuglielmo, Jeff Wrana

Publikováno v: Cancer Research. 64:6402-6409

Transforming growth factor (TGF)-β1 is associated with tumor progression and resistance to chemotherapy in established cancers, as well as host immune suppression. Here, we show that the serum glycoprotein α2-HS-glycoprotein (AHSG) blocks TGF-β1 b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50811b9af79c6033cb9da82a9baf1ca7
https://doi.org/10.1158/0008-5472.can-04-1117

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K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis

Autor: Steve Gallinger, Alan Medline, Kazy Hay, M A Ward, B Shpitz, Hartley Stern, W R Bruce, A A Vivona

Publikováno v: Carcinogenesis. 14:1777-1781

Ras mutations are an important early event in a number of carcinogen-induced rodent tumors. Colon carcinogenesis induced in rats by azoxymethane is a useful model as it mimics the adenoma-carcinoma sequence observed in humans. In addition, aberrant c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7818f2d30a90cff025eddad920ec002e
https://doi.org/10.1093/carcin/14.9.1777

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Compartmental analysis of the pharmacokinetics of radioiodinated monoclonal antibody B72.3 in colon cancer patients

Autor: Beverly J. Schmocker, Hartley Stern, Robert D. Odze, Jeannie Polihronis, Sylvain Houle, Jake J. Thiessen, Joel A. Kirsh, Manzur T. Damani, Kazy Hay, Steven Gallinger, Raymond M. Reilly

Publikováno v: Nuclear medicine and biology. 20(1)

Sixteen patients with colorectal cancer were administered 37–74 MBq (1 mg) of radioiodinated B72.3 monoclonal antibody. Pharmacokinetic analysis was carried out on plasma and urine samples. Elimination from the plasma was biexponential with a mean

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c6c1f45492a2d288f5c85f7b0b304e
https://pubmed.ncbi.nlm.nih.gov/8461880

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Colonic epithelial proliferation indices before and after colon cancer removal

Autor: Roger C. Gregoire, Hanoch Kashtan, Hartley Stern, Kazy Hay

Publikováno v: Cancer investigation. 11(2)

Rectal mucosal (epithelial) proliferation labeling indices (LI) have been widely used as a risk marker for colorectal cancer and as an intermediate end-point in chemoprevention studies. The purpose of this study was to determine whether the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4340f8f8e1af6dd27f4316fd3547d39e
https://pubmed.ncbi.nlm.nih.gov/8462011

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