Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Kazuyuki Takata"'
Autor:
Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata
Publikováno v:
Regenerative Therapy, Vol 25, Iss , Pp 229-237 (2024)
Introduction: Cell therapeutic clinical trials using fetal mesencephalic tissue provided a proof-of-concept for regenerative therapy in patients with Parkinson's disease. Postmortem studies of patients with fetal grafts revealed that α-synuclein+ Le
Externí odkaz:
https://doaj.org/article/d10ffc09f08546f48fc70c58246c770c
Publikováno v:
Neuropsychopharmacology Reports, Vol 43, Iss 3, Pp 440-445 (2023)
Abstract Aim Nicotinic acetylcholine receptors (nAChRs) expressed in midbrain dopaminergic (mDA) neurons modulate mDA neuronal activity. However, their expression patterns and functional roles during mDA neuronal development remain unknown. Here, we
Externí odkaz:
https://doaj.org/article/e05495dc7da14d76bbc4fc04ce0cdf34
Autor:
Masanori Hijioka, Kanori Kitamura, Daijiro Yanagisawa, Kaneyasu Nishimura, Kazuyuki Takata, Masatoshi Inden, Yoshihisa Kitamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 3, Pp 183-187 (2020)
Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert a
Externí odkaz:
https://doaj.org/article/6f342e388074485b8a5d8c48427bd00c
Publikováno v:
Life, Vol 13, Iss 1, p 221 (2023)
The vascular system of the prenatal brain is crucial for the development of the central nervous system. Communication between vessels and neural cells is bidirectional, and dysfunctional communication can lead to neurodevelopmental diseases. In the p
Externí odkaz:
https://doaj.org/article/f3d5523693804b30a5dab4d61a47d462
Publikováno v:
Stem Cell Research, Vol 55, Iss , Pp 102486- (2021)
Human induced pluripotent stem cells (hiPSCs) are powerful tools for modeling human brain development and treating neurodegenerative diseases. Here we established a robust protocol with high scalability for generating striatal medium spiny neurons (M
Externí odkaz:
https://doaj.org/article/19fa7652e6ec4c6abdc9fc70e4afd2b9
Autor:
Kazuyuki Takata, Hiroyuki Kimura, Daijiro Yanagisawa, Koki Harada, Kaneyasu Nishimura, Yoshihisa Kitamura, Shun Shimohama, Ikuo Tooyama
Publikováno v:
Molecules, Vol 27, Iss 9, p 2780 (2022)
Amyloid-β (Aβ) accumulation and tauopathy are considered the pathological hallmarks of Alzheimer’s disease (AD), but attenuation in choline signaling, including decreased nicotinic acetylcholine receptors (nAChRs), is evident in the early phase o
Externí odkaz:
https://doaj.org/article/ab2ff8dbd79c4906ad9553a201dbf8b7
Autor:
Masatoshi Inden, Mari Abe, Hideaki Minamino, Kazuyuki Takata, Kanji Yoshimoto, Ikuo Tooyama, Yoshihisa Kitamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 119, Iss 1, Pp 10-19 (2012)
l-Dihydroxyphenylalanine (l-DOPA) is considered the gold standard for the treatment of Parkinson’s disease (PD). However, long-term administration of l-DOPA can induce abnormal side effects. On the other hand, selective serotonin reuptake inhibitor
Externí odkaz:
https://doaj.org/article/ddeb01d899be4cc7a79ee337331666e9
Autor:
Kazuyuki Takata, Yoshihisa Kitamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 118, Iss 3, Pp 331-337 (2012)
Pathological hallmarks of Alzheimer’s disease (AD) include senile plaques, neurofibrillary tangles (NFTs), synaptic loss, and neurodegeneration. Senile plaques are composed of amyloid-β (Aβ) and are surrounded by microglia, a primary immune effec
Externí odkaz:
https://doaj.org/article/d2a0979cf4a74fa1b8e872da3b29622c
Autor:
Masatoshi Inden, Yoshihisa Kitamura, Kazunori Takahashi, Kazuyuki Takata, Natsuko Ito, Rina Niwa, Risa Funayama, Kaneyasu Nishimura, Takashi Taniguchi, Toshio Honda, Takahiro Taira, Hiroyoshi Ariga
Publikováno v:
Journal of Pharmacological Sciences, Vol 117, Iss 3, Pp 189-203 (2011)
Abstract.: DJ-1, Parkinson’s disease PARK7, acts as an oxidative stress sensor in neural cells. Recently, we identified the DJ-1 modulator UCP0054278 by in silico virtual screening. However, the effect of the peripheral administration of UCP0054278
Externí odkaz:
https://doaj.org/article/ff495e9e810244f7ad6576eaec9006a7
Autor:
Takashi Yanagida, Yoshihisa Kitamura, Koichiro Yamane, Kazunori Takahashi, Kazuyuki Takata, Daijiro Yanagisawa, Hiroyuki Yasui, Takashi Taniguchi, Takahiro Taira, Toshio Honda, Hiroyoshi Ariga
Publikováno v:
Journal of Pharmacological Sciences, Vol 109, Iss 3, Pp 463-468 (2009)
Although a loss-of-function type mutation was identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtu
Externí odkaz:
https://doaj.org/article/d571d4b8b6fb479f90ecc2164502904d