Výsledky vyhledávání - "Kazuyuki Saga"

Analysis of Humoral Immune Response in Experimental Autoimmune Pancreatitis in Mice

Autor: Toshiro Fukui, Kazushige Uchida, Masahiro Kido, Norihiko Watanabe, Junya Tanaka, Tsutomu Chiba, Akiyoshi Nishio, Takuji Akamatsu, Kazuyuki Saga, Masanori Asada, Kazuichi Okazaki

Publikováno v: Pancreas. 39:224-231

To study the autoimmune response in MRL/Mp mice, which spontaneously develop pancreatitis in the exocrine pancreatic tissue.Six-week-old female mice were injected intraperitoneally with polyinosinic polycytidylic acid at a dose of 5 mg/kg of body wei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6a7887beccd2deadc170ad490c8764
https://doi.org/10.1097/mpa.0b013e3181bab5e2

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Proinflammatory Th2 Cytokines Induce Production of Thymic Stromal Lymphopoietin in Human Colonic Epithelial Cells

Autor: Junya Tanaka, Tsutomu Chiba, Hisayo Nishiura, Norihiko Watanabe, Masahiro Kido, Takuji Akamatsu, Kazuyuki Saga

Publikováno v: Digestive Diseases and Sciences

Purpose Thymic stromal lymphopoietin (TSLP) is released by intestinal epithelial cells (IECs), and TSLP-conditioned dendritic cells appear to be involved in immune homeostasis of intestine and immunoglobulin A (IgA) class-switching in the physiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66ac1d5a87bbdbe73dac64c69a5bbba
https://doi.org/10.1007/s10620-009-0979-x

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Human TSLP and TLR3 ligands promote differentiation of Th17 cells with a central memory phenotype under Th2‐polarizing conditions

Autor: Takuji Akamatsu, Junya Tanaka, Tsutomu Chiba, Akiyoshi Nishio, Kazuyuki Saga, Masahiro Kido, Norihiko Watanabe

Publikováno v: Clinical and Experimental Allergy

Summary Background Human thymic stromal lymphopoietin (TSLP) is expressed in the human asthmatic lung and activates dendritic cells (DCs) to strongly induce proallergic T-helper type 2 (Th2) cell responses, suggesting that TSLP plays a critical role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe01e6de89ff1596952855f29eeae8d
http://europepmc.org/articles/PMC7164823

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Human TSLP directly enhances expansion of CD8+ T cells

Autor: Takuji Akamatsu, Junya Tanaka, Tsutomu Chiba, Akiyoshi Nishio, Kazuyuki Saga, K. Kuzushima, Norihiko Watanabe, Masahiro Kido

Publikováno v: Clinical and Experimental Immunology. 154:98-106

SummaryHuman thymic stromal lymphopoietin (TSLP) promotes CD4+ T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8+ T-cell proliferation, it is not clear whether TSLP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ed48c7d0bb74364fbf41197cff940
https://doi.org/10.1111/j.1365-2249.2008.03731.x

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Fatal autoimmune hepatitis induced by concurrent loss of naturally arising regulatory T cells and PD-1-mediated signaling

Autor: Takuji Akamatsu, Kazuyuki Saga, Masahiro Kido, Junya Tanaka, Tasuku Honjo, Tsutomu Chiba, Akiyoshi Nishio, Norihiko Watanabe, Taku Okazaki

Publikováno v: Gastroenterology. 135(4)

Background & Aims: Because of the lack of animal models developing spontaneous autoimmune hepatitis (AIH), the molecular mechanisms involved in the development of AIH are still unclear. This study aims to examine the regulatory roles of naturally ari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01675d99d47aff5767cfbee163fd13a6
https://pubmed.ncbi.nlm.nih.gov/18651994

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Cross-primed CD8+ cytotoxic T cells induce severe Helicobacter-associated gastritis in the absence of CD4+ T cells

Autor: Toshiro Fukui, Masahiro Kido, Norihiko Watanabe, Norimitsu Uza, Kazuichi Okazaki, Katsuhiro Kasahara, Junya Tanaka, Tsutomu Chiba, Akiyoshi Nishio, Masanori Asada, Kazuyuki Saga, Hiroshi Nakase, Satoru Ueno, Shinya Ohashi

Publikováno v: Helicobacter. 12(5)

Background Although previous studies have reported important roles of CD4(+) type 1-helper T cells and regulatory T cells in Helicobacter-associated gastritis, the significance of CD8(+) cytotoxic T cells remains unknown. To study the roles of CD8(+)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f41e5346a70c80045d3670825bbb28
https://pubmed.ncbi.nlm.nih.gov/17760716

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Essential role of Peyer's patches in the development of Helicobacter-induced gastritis

Autor: Kazuyuki Saga, Masahiro Kido, Kazuichi Okazaki, Shinya Ohashi, Junya Tanaka, Tsutomu Chiba, Akiyoshi Nishio, Toshiro Fukui, Norihiko Watanabe, Keiichi Kiriya, Takuji Akamatsu, Masanori Asada

Publikováno v: International immunology. 19(4)

Helicobacter bacteria colonize in the stomach and induce strong, specific local and systemic humoral and cell-mediated immunity. Helicobacter binds to the host epithelial cells, directly triggering the recruitment of neutrophils. Local inflammatory p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897ee5e135b72ccad3c44302b5bd46b3
https://pubmed.ncbi.nlm.nih.gov/17314082

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788 Development of a New Mouse Model of Fatal Autoimmune Hepatitis

Autor: Takuji Akamatsu, Kazuyuki Saga, Masahiro Kido, Norihiko Watanabe, Junya Tanaka, Tsutomu Chiba, Akiyoshi Nishio

Publikováno v: Gastroenterology. 134:A-771

Background: An aberrant regulation of autoreactive T cells against liver antigens appears to initiate development of autoimmune hepatitis (AIH), characterized by mononuclear-cell infiltration and autoantibody production. Because of the lack of animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::086278071fea1908f0a142f797d72f77
https://doi.org/10.1016/s0016-5085(08)63599-4

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