Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kazuyuki Ohmoto"'
Autor:
Yoshiyuki Aratani, Hidekazu Matsuya, Koji Yoshida, Masato Higashino, Atsushi Naganawa, Hiroyuki Takeda, Akihiro Kinoshita, Keisuke Hanada, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:200-214
A highly potent and well-balanced dual agonist for the EP2 and EP3 receptors is described. Optimization of the lead compound was accomplished in consideration of the relative agonist activity against each EP subtype receptor and the pharmacokinetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e5a038bf3b1ac9687e5fd070824092
https://doi.org/10.1016/j.bmc.2017.11.035
https://doi.org/10.1016/j.bmc.2017.11.035
Autor:
Hidekazu Matsuya, Yoshiyuki Aratani, Masato Higashino, Akihiro Kinoshita, Kazuyuki Ohmoto, Akito Kakuuchi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1016-1019
The cyclic carbamate derivatives, 2-{[2-((4S)-4-{(1E,3R)-8-fluoro-3-hydroxy-4,4-dimethyl-1-octenyl}-2-oxo-1,3-oxazolidin-3-yl)ethyl]sulfanyl}-1,3-thiazole-4-carboxylic acid (5) and 2-{[2-((4S)-4-{(1E,3R)-3-[1-(4-fluorobutyl)cyclobutyl]-3-hydroxy-1-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a560699e3534685aede696fd825be5c
https://doi.org/10.1016/j.bmcl.2015.12.039
https://doi.org/10.1016/j.bmcl.2015.12.039
Autor:
Akihiro, Kinoshita, Masato, Higashino, Koji, Yoshida, Yoshiyuki, Aratani, Akito, Kakuuchi, Keisuke, Hanada, Hiroyuki, Takeda, Atsushi, Naganawa, Hidekazu, Matsuya, Kazuyuki, Ohmoto
Publikováno v:
Bioorganicmedicinal chemistry. 26(1)
A highly potent and well-balanced dual agonist for the EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cecf82fc6035858f7d7798ca4b5c57c2
https://pubmed.ncbi.nlm.nih.gov/29203142
https://pubmed.ncbi.nlm.nih.gov/29203142
Publikováno v:
Journal of the Japan Institute of Energy. 87:461-467
The LNG heat storage system for liquid hydrogen production system of 10,000Nm3/h was investigated. The LNG enthalpy change for vaporization is used to save energy of the compressor for the recycle hydrogen of liquid hydrogen process. As the LNG canno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::710352d9cfe160084eccd754b38294a3
https://doi.org/10.3775/jie.87.461
https://doi.org/10.3775/jie.87.461
Autor:
Yoshisuke Nakayama, Yasuo Yonetomi, Akiharu Ishida, Satoshi Itadani, Akira Imagawa, Hiroaki Nomura, Junya Ueda, Katsuya Hisaichi, Kazuyuki Ohmoto, Masaki Ima, Nobukazu Ohta, Takeshi Nabe, Hiromu Egashira, Atsushi Kinoshita, Tetsuya Kitamine, Michiaki Kadode, Hideki Moriguchi, Manabu Fujita, Yoshiyuki Aratani, Tomohiko Sekioka, Kentaro Yashiro, Yohei Tajima, Yoshiyuki Yamaura, Tetsuya Sekiguchi, Takafumi Nakao, Atsuto Inoue, Naoya Matsumura, Shinya Takahashi, Jun Takeuchi
Publikováno v:
Journal of medicinal chemistry. 58(15)
An orally active dual CysLT1 and CysLT2 antagonist possessing a distinctive structure which consists of triple bond and dicarboxylic acid moieties is described. Gemilukast (ONO-6950) was generated via isomerization of the core indole and the incorpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6528ca6d6fa73481e590b5866bf0970a
https://pubmed.ncbi.nlm.nih.gov/26200813
https://pubmed.ncbi.nlm.nih.gov/26200813
Autor:
Tomohiro Niwa, Masashi Kato, Yoshiyuki Yamaura, Hideaki Suna, Katsukuni Mitsui, Noriko Morimoto, Yuji Kawahara, Seishi Katsumata, Kazuyuki Ohmoto, Naoki Yoshimoto
Publikováno v:
Neuropharmacology. 99
Accumulating evidence has shown the pathophysiological significance of the translocator protein 18 kDa (TSPO) in the central nervous system. In this study, we evaluated the beneficial effects of ONO-2952, a novel TSPO antagonist in rat stress models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805ee15beb12879db96d3ff7fa195d69
https://pubmed.ncbi.nlm.nih.gov/26189762
https://pubmed.ncbi.nlm.nih.gov/26189762
Autor:
Akira Imagawa, Hiroshi Mori, Yasuo Ochi, Makoto Tanaka, Kazuyuki Ohmoto, Hiroyuki Yamada, Naoki Kawada, Kazuhito Kawabata
Publikováno v:
Journal of bone and mineral metabolism. 34(1)
This study examined the effects of a novel cathepsin K inhibitor, ONO-KK1-300-01 (KK1-300), used concurrently with parathyroid hormone (PTH) in ovariectomized (OVX) rats. KK1-300 (3 mg/kg, twice daily), alendronate (1 mg/kg, once daily) or vehicle we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d9da0383ca9ba975d939e85849c9ab
https://pubmed.ncbi.nlm.nih.gov/25762435
https://pubmed.ncbi.nlm.nih.gov/25762435
Autor:
Yoshihiko Odagaki, Motohiro Okuma, Albert Gyorkos, Tomohiko Sekioka, Toshihide Horiuchi, Maciej Wieczorek, Kazuyuki Ohmoto, Lyle W. Spruce, Masaaki Toda, Kazuhito Kawabata, Hisao Nakai, John C. Cheronis, Yasushi Hirota, Hirotoshi Imanishi, Tetsuya Yamamoto, Shozo Matsuoka
Publikováno v:
Journal of Medicinal Chemistry. 44:1268-1285
5-Amino-2-phenylpyrimidin-6-ones, some of their desamino derivatives, and miscellaneous derivatives were synthesized and biologically evaluated on both in vitro activity and oral activity in an acute hemorrhagic assay. These compounds contained an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753dfaa6a46bd5f35a98365d51dd2444
https://doi.org/10.1021/jm000410y
https://doi.org/10.1021/jm000410y
Autor:
Yoshihiko Odagaki, Nobuyuki Hamanaka, Masaaki Toda, S. Matsuoka, Kazuyuki Ohmoto, Y. Katsuya, Hisao Nakai
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:647-651
The crystal structure of a new inhibitor of human neutrophil elastase (HNE), N-[2-[5-(tert-butyl)-1,3,4-oxadiazol-2-yl]-(1RS)-1-(methylethyl)-2-oxoethyl]-2-(5-amino-6-oxo-2-phenyl-6H-pyrimidin-1-ly)acetamide (ONO-6818, 1) complexed to porcine pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c220ce04cdbd1906076c60961f1c1d
https://doi.org/10.1016/s0968-0896(00)00277-7
https://doi.org/10.1016/s0968-0896(00)00277-7
Autor:
Masanori Kawamura, Tetsuya Yamamoto, Tsutomu Kojima, Kazuyuki Ohmoto, Shinsuke Hashimoto, Masaaki Toda, Toshihide Horiuchi, Katsutoshi Hachiya, Hisao Nakai
Publikováno v:
Synlett. 2001:0299-0301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d103fe35992e5baceaf1ca55b530a196
https://doi.org/10.1055/s-2001-10786
https://doi.org/10.1055/s-2001-10786